2024
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2015
DNA Methylation Regulates the Differential Expression of CX3CR1 on Human IL-7Rαlow and IL-7Rαhigh Effector Memory CD8+ T Cells with Distinct Migratory Capacities to the Fractalkine
Shin MS, You S, Kang Y, Lee N, Yoo SA, Park K, Kang KS, Kim SH, Mohanty S, Shaw AC, Montgomery RR, Hwang D, Kang I. DNA Methylation Regulates the Differential Expression of CX3CR1 on Human IL-7Rαlow and IL-7Rαhigh Effector Memory CD8+ T Cells with Distinct Migratory Capacities to the Fractalkine. The Journal Of Immunology 2015, 195: 2861-2869. PMID: 26276874, PMCID: PMC4561204, DOI: 10.4049/jimmunol.1500877.Peer-Reviewed Original ResearchConceptsDNA methylationDifferential expressionGene expressionCellular traitsEpigenetic mechanismsGene promoterGenome-wide DNA methylationDistinct traitsDNA methylation statusIndividual gene expressionMigratory capacityAutocrine amplification loopImportant biological outcomesPotential biological implicationsMammalian cellsMethylationMethylation statusAmplification loopBiological outcomesTraitsBiological implicationsPromoterEffector memoryExpressionT cells
2014
Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling
Lee N, Shin MS, Kang KS, Yoo SA, Mohanty S, Montgomery RR, Shaw AC, Kang I. Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. Clinical Immunology 2014, 152: 101-110. PMID: 24657713, PMCID: PMC4018768, DOI: 10.1016/j.clim.2014.03.003.Peer-Reviewed Original Research
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response
2001
CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis
Bockenstedt L, Kang I, Chang C, Persing D, Hayday A, Barthold S. CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis. Infection And Immunity 2001, 69: 5264-5269. PMID: 11500394, PMCID: PMC98634, DOI: 10.1128/iai.69.9.5264-5269.2001.Peer-Reviewed Original ResearchConceptsAlphabeta T-cell-deficient miceT cell-deficient miceMurine Lyme carditisT cellsLyme carditisB cellsT helper 1 cellsAnti-inflammatory cytokines mRNA levelsTumor necrosis factor alphaBurgdorferi-specific antibodiesInfected control miceProminent macrophage infiltrateCell-mediated immunityT cell responsesT helper 1Murine Lyme borreliosisCytokine mRNA levelsNecrosis factor alphaAlphabeta T cellsPrincipal immune cellsMouse strain backgroundAdoptive transferAcute arthritisMacrophage infiltratesControl mice
1998
Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway
Shanafelt M, Kang I, Barthold S, Bockenstedt L. Modulation of Murine Lyme Borreliosis by Interruption of the B7/CD28 T-Cell Costimulatory Pathway. Infection And Immunity 1998, 66: 266-271. PMID: 9423867, PMCID: PMC107886, DOI: 10.1128/iai.66.1.266-271.1998.Peer-Reviewed Original ResearchAbataceptAnimalsAntibodies, BacterialAntibodies, BlockingAntigens, CDAntigens, DifferentiationArthritis, InfectiousB7-1 AntigenB7-2 AntigenCD28 AntigensCTLA-4 AntigenFemaleImmunoconjugatesImmunoglobulin GInterferon-gammaInterleukin-4Lyme DiseaseLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CSpecific Pathogen-Free OrganismsTh1 CellsTh2 CellsUp-Regulation