2018
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome
Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy S, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome. Arthritis & Rheumatology 2018, 71: 109-120. PMID: 30009530, PMCID: PMC6310104, DOI: 10.1002/art.40672.Peer-Reviewed Original ResearchMeSH KeywordsAntigen-Antibody ComplexAutoantibodiesBlotting, WesternCARD Signaling Adaptor ProteinsEnzyme-Linked Immunosorbent AssayFlow CytometryHumansInflammasomesInterleukin-1betaIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMass SpectrometryMonocytesNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, ImmunologicRibonucleoprotein, U1 Small NuclearConceptsMacrophage migration inhibitory factorSystemic lupus erythematosusMigration inhibitory factorNLRP3 inflammasome activationImmune complexesIL-1βNLRP3 inflammasomeHuman monocytesInflammasome activationExpression of MIFProduction of MIFInhibitory factorCaspase-1IL-1β levelsIL-1β productionEnzyme-linked immunosorbentQuantitative polymerase chain reactionHigh expression alleleLupus patientsMIF productionMIF receptorInflammatory characteristicsLupus erythematosusInterleukin-1βPolymerase chain reaction
2012
U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes
Shin MS, Kang Y, Lee N, Kim SH, Kang KS, Lazova R, Kang I. U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes. The Journal Of Immunology 2012, 188: 4769-4775. PMID: 22490866, PMCID: PMC3347773, DOI: 10.4049/jimmunol.1103355.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodiesCarrier ProteinsHumansInterleukin-1betaLipopolysaccharide ReceptorsLupus Erythematosus, SystemicMonocytesNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesRibonucleoprotein, U1 Small NuclearConceptsU1 snRNPNuclear ribonucleoproteinSystemic lupus erythematosusIL-1β productionU1 small nuclear RNAU1 small nuclear ribonucleoproteinSmall nuclear ribonucleoproteinCytosolic protein complexesLupus erythematosusAutoimmune diseasesProtein complexesMicrobial nucleic acidsNuclear RNAPre-mRNAHuman monocytesNOD-like receptor familyReactive oxygen speciesEndogenous DNAReceptor familyMolecular complexesOxygen speciesRibonucleoproteinTLR7/8 pathwayIL-1βNuclear molecules