2017
Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Shin M, Kang Y, Leng L, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex. The Journal Of Immunology 2017, 198: 210.3-210.3. DOI: 10.4049/jimmunol.198.supp.210.3.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorIL-1β productionImmune complexesIL-1βHuman monocytesNLRP3 inflammasomeProduction of MIFExogenous MIFInhibitory factorMIF gene polymorphismsSerum MIF levelsLupus-prone miceSystemic lupus erythematosusExpression of NLRP3Subsequent tissue injuryIL-1beta productionNF-kB activationCaspase-1 activationMIF antagonistMIF levelsLupus patientsLupus erythematosusNLRP3 expressionAutoantibody production
2006
CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features
KANG I, CRAFT J. CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features. 2006, 357-367. DOI: 10.1016/b978-012595961-2/50031-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusPlasmacytoid dendritic cellsT cellsAdaptive immunityImmune complexesAberrant innate immune responsesAdaptive immune cellsUpregulation of IFNSubsequent tissue injuryPeripheral blood cellsInnate immune responseActivation of complementRespective autoantigensDendritic cellsLupus erythematosusData support rolesImmune cellsSerologic hallmarkTissue injuryClinical diseaseImmune responseTarget organsFc receptorsB cellsImmune system