2023
Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4 +T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2018
Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis
Lee H, Lee J, Kang I, Choi J. Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis. The Journal Of Immunology 2018, 200: 51.7-51.7. DOI: 10.4049/jimmunol.200.supp.51.7.Peer-Reviewed Original ResearchT cellsT cell antigen receptorIL-17AIL-23Memory CD4IL-1βImmune responseAutoimmune disease pathogenesisPro-inflammatory cytokinesIFN-γ expressionNaïve T cellsT cell activationAutoimmune neuroinflammationImmunopathological roleTh17 cellsAutoimmune pathogenesisBystander activationBystander CD4T lymphocytesIL-1Interleukin-1CD4Disease pathogenesisCell activationCell antigen receptor
2010
1,25-dihyroxyvitamin D3 enhances the activity of the FOXP3 gene in human CD4+ T cells through directly binding to putative VDRE sites in the FOXP3 gene (49.2)
Kang I, Kim S, Lee W, Kang S, Lee J. 1,25-dihyroxyvitamin D3 enhances the activity of the FOXP3 gene in human CD4+ T cells through directly binding to putative VDRE sites in the FOXP3 gene (49.2). The Journal Of Immunology 2010, 184: 49.2-49.2. DOI: 10.4049/jimmunol.184.supp.49.2.Peer-Reviewed Original ResearchVitamin D receptorFOXP3 geneT cellsHuman CD4Dihyroxyvitamin D3Retinoid X receptorCNS regionsPresence of VDRFoxp3 promoter activityHuman FOXP3 geneImmune regulatory effectsFoxp3 gene expressionFOXP3 gene promoterBinding of VDRD receptorCD4X receptorPromoter activityResponse element siteRegulatory effectsVDREPutative response elementsReceptorsD3Response elementAge-associated alteration in naive and memory Th17 cell response in humans (85.8)
Lee J, Lee W, Kim S, Kang S, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans (85.8). The Journal Of Immunology 2010, 184: 85.8-85.8. DOI: 10.4049/jimmunol.184.supp.85.8.Peer-Reviewed Original ResearchRisk of infectionT cellsIL-17Naive CD4Peripheral bloodCell responsesIL-17-producing CD4IL-17-producing cellsFrequency of IFNTh17-polarizing cytokinesT cell immunityIFN-γ levelsT cell subsetsPMA/ionomycin stimulationAge-associated alterationsT cell receptorTh17 cellsCell immunityMemory CD4Tissue culture supernatantsAutoimmune diseasesCell subsetsMemory subsetsCD4Extracellular microorganisms
2009
Alterations in the Kinetics of CD4+ T Cell Responses with Aging
Hong M, Dan J, Lee W, Kang I. Alterations in the Kinetics of CD4+ T Cell Responses with Aging. Journal Of Rheumatic Diseases 2009, 16: 271-280. DOI: 10.4078/jkra.2009.16.4.271.Peer-Reviewed Original ResearchKinetics of CD4T cell proliferationHr of stimulationT cell activationT cellsCD40L expressionCell proliferationCell activationPeripheral blood mononuclear cellsT cell immunityT cell responsesAnti-CD28 antibodiesBlood mononuclear cellsActivation marker CD69Duration of stimulationRisk of infectionT cell receptor stimulationAge-associated changesCell receptor stimulationYounger patientsCell immunityCD25 expressionMononuclear cellsElderly subjectsCD4
2007
The effect of aging on CD4+ Foxp3+ T cells in humans (85.23)
Kang I, Kim H, Hwang K. The effect of aging on CD4+ Foxp3+ T cells in humans (85.23). The Journal Of Immunology 2007, 178: s122-s122. DOI: 10.4049/jimmunol.178.supp.85.23.Peer-Reviewed Original ResearchT cellsRegulatory T cell functionFunction of CD4IL-10 productionT cell traffickingImmunosuppressive functionMemory phenotypeCTLA-4Immune regulationFoxp3CD4Therapeutic strategiesCell traffickingInhibitory effectYoung individualsCell functionCell proliferationComparable frequencyLatter cellsSuch cellsCellsGroupPhenotypeChemokinesHumans
2003
Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation
Park S, Kang I, Kim H, Craft J. Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation. Arthritis Research & Therapy 2003, 5: 151. PMCID: PMC2833942, DOI: 10.1186/ar952.Peer-Reviewed Original Research