2024
Expression of IL-7RαlowCX3CR1+ CD8+ T Cells and α4β7 Integrin Tagged T Cells Related to Mucosal Immunity in Children with Inflammatory Bowel Disease
Yang D, Kim H, Dinh D, Yang J, Hyun C, Jee Y, Lee N, Shin M, Kang I, Kang K. Expression of IL-7RαlowCX3CR1+ CD8+ T Cells and α4β7 Integrin Tagged T Cells Related to Mucosal Immunity in Children with Inflammatory Bowel Disease. Pediatric Gastroenterology Hepatology & Nutrition 2024, 27: 345-354. PMID: 39563840, PMCID: PMC11570351, DOI: 10.5223/pghn.2024.27.6.345.Peer-Reviewed Original ResearchCD8<sup>+</sup> T cellsPeripheral blood mononuclear cellsCD4<sup>+</sup> T cellsInflammatory bowel diseaseT cellsUlcerative colitis groupCrohn's disease groupEffector memoryColitis groupControl groupEffector memory CD8<sup>+</sup> T cellsMemory CD8<sup>+</sup> T cellsCD8+ T cellsBowel diseaseEM CD8<sup>+</sup> T cellsTrafficking immune cellsDisease groupPathogenesis of ulcerative colitisBlood mononuclear cellsInflamed intestinal mucosaConcentrations of TNF-aIntestinal mucosaSerum levelsT lymphocytesImmune cells
2019
Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults
Park H, Shin M, Kim M, Bilsborrow J, Mohanty S, Montgomery R, Shaw A, Yoo S, Kang I. Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults. The Journal Of Immunology 2019, 202: 181.22-181.22. DOI: 10.4049/jimmunol.202.supp.181.22.Peer-Reviewed Original ResearchPeripheral blood cellsPeripheral blood mononuclear cellsInfluenza vaccine responsesT cellsEM CD8Memory CD8Vaccine responsesOlder adultsBlood cellsSignature genesEffector memory CD8Blood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Expression profilesSignificant associationTranscription factorsWhole bloodTranscriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profiles
2016
Changes in T cell immunity in patients with metastatic castration resistant prostate treated with Radium-223 treatment.
Kim J, Kang Y, Shin M, Deshpande H, Hurwitz M, Roberts J, Cardinale J, Narayana A, Kang I, Petrylak D. Changes in T cell immunity in patients with metastatic castration resistant prostate treated with Radium-223 treatment. Journal Of Clinical Oncology 2016, 34: 295-295. DOI: 10.1200/jco.2016.34.2_suppl.295.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerPeripheral blood mononuclear cellsT cell immunityT cellsCell immunityOsseous metastasesMetastatic castration-resistant prostateCastration-resistant prostate cancerIL-7 receptor alpha chainRadium-223 treatmentEffector memory CD8PD-1 expressionEffector T cellsDeath protein 1Resistant prostate cancerCastration-resistant prostateBlood mononuclear cellsFollowing time pointsCocktail of antibodiesHost immune systemReceptor alpha chainCalcium mimeticEligible patientsEM CD8Median PSA
2013
Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083)
Shin M, Kang Y, Lee N, Kim S, Kang K, Lazova R, Kang I. Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies (P4083). The Journal Of Immunology 2013, 190: 127.13-127.13. DOI: 10.4049/jimmunol.190.supp.127.13.Peer-Reviewed Original ResearchIL-1β productionAnti-dsDNA antibodiesIL-1βHuman monocytesReactive oxygen speciesCell responsesIL-1β dependent mannerPro-inflammatory cytokines IL-1βPeripheral blood mononuclear cellsSelf-nuclear antigensIL-17 productionSystemic lupus erythematosusInnate immune cellsBlood mononuclear cellsPathogenesis of lupusAntibody-positive seraCytokines IL-1βLupus pathogenesisLupus patientsLupus erythematosusAutoimmune responseCutaneous lesionsMononuclear cellsImmune cellsNLRP3 inflammasome
2012
Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1)
Kim H, Cho B, Sim J, Kim H, Yoo W, Kang I, Lee E. Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1). The Journal Of Immunology 2012, 188: 69.1-69.1. DOI: 10.4049/jimmunol.188.supp.69.1.Peer-Reviewed Original ResearchRheumatoid arthritisT cellsEM CD8Synovial fluidRA patientsMemory CD8Peripheral bloodMononuclear cellsHealthy controlsIL-10-producing CD8IL-4-producing CD8Synovial fluid mononuclear cellsProgression of RAPeripheral blood mononuclear cellsFluid mononuclear cellsEffector memory CD8T cell subsetsBlood mononuclear cellsKi-67 stainingDisease activitySuppressor cellsPD-1IL-15Cell subsetsLess perforin
2010
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells
2009
Alterations in the Kinetics of CD4+ T Cell Responses with Aging
Hong M, Dan J, Lee W, Kang I. Alterations in the Kinetics of CD4+ T Cell Responses with Aging. Journal Of Rheumatic Diseases 2009, 16: 271-280. DOI: 10.4078/jkra.2009.16.4.271.Peer-Reviewed Original ResearchKinetics of CD4T cell proliferationHr of stimulationT cell activationT cellsCD40L expressionCell proliferationCell activationPeripheral blood mononuclear cellsT cell immunityT cell responsesAnti-CD28 antibodiesBlood mononuclear cellsActivation marker CD69Duration of stimulationRisk of infectionT cell receptor stimulationAge-associated changesCell receptor stimulationYounger patientsCell immunityCD25 expressionMononuclear cellsElderly subjectsCD4