2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
2019
Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults
Park H, Shin M, Kim M, Bilsborrow J, Mohanty S, Montgomery R, Shaw A, Yoo S, Kang I. Transcriptomic analysis of human IL-7 receptor alphalow and higheffector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults. The Journal Of Immunology 2019, 202: 181.22-181.22. DOI: 10.4049/jimmunol.202.supp.181.22.Peer-Reviewed Original ResearchPeripheral blood cellsPeripheral blood mononuclear cellsInfluenza vaccine responsesT cellsEM CD8Memory CD8Vaccine responsesOlder adultsBlood cellsSignature genesEffector memory CD8Blood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Expression profilesSignificant associationTranscription factorsWhole bloodTranscriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults
Park H, Shin MS, Kim M, Bilsborrow JB, Mohanty S, Montgomery RR, Shaw AC, You S, Kang I. Transcriptomic analysis of human IL‐7 receptor alpha low and high effector memory CD8+ T cells reveals an age‐associated signature linked to influenza vaccine response in older adults. Aging Cell 2019, 18: e12960. PMID: 31044512, PMCID: PMC6612637, DOI: 10.1111/acel.12960.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood mononuclear cellsEffector memory CD8Influenza vaccine responsesEM CD8T cellsIL-7RαMemory CD8Vaccine responsesBlood cellsOlder adultsIL-7 receptor alphaSignature genesBlood mononuclear cellsHuman peripheral whole bloodAge-associated expansionPeripheral whole bloodGene expression profilesAge-associated changesMeta-analysis studyGlobal transcriptomic profilesMononuclear cellsCD8Receptor alphaExpression profiles
2012
The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16)
Lee N, Lee W, Shin M, Kang Y, Jeon S, Kang I. The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16). The Journal Of Immunology 2012, 188: 105.16-105.16. DOI: 10.4049/jimmunol.188.supp.105.16.Peer-Reviewed Original ResearchEM CD8IFN-α levelsT cellsCMV infectionCytomegalovirus infectionIL-7 Receptor α ExpressionHuman effector memory CD8IL-7 receptor alphaCMV immune statusEffector memory CD8Elderly peopleT cell subsetsReceptor α expressionT cell homeostasisAge-associated expansionHigh-affinity receptorCytokine levelsMemory CD8Naïve CD8Cell subsetsImmune statusPlasma levelsCD8IL-7Α expression
2011
Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11)
Shin M, Lee W, Lee J, Kim S, Lee N, Kang I. Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11). The Journal Of Immunology 2011, 186: 150.11-150.11. DOI: 10.4049/jimmunol.186.supp.150.11.Peer-Reviewed Original ResearchMemory CD8T cellsAge-associated expansionYoung donorsCMV infectionIL-15Elderly donorsIL-15-mediated proliferationT cell receptor repertoireTCR-mediated proliferationIL-15 expressionCell receptor repertoireCell subsetsCD8Better survivalReceptor repertoireCMVElderly peoplePotential roleSignificant differencesIndependent mechanismsInfectionProliferationSurvivalCells
2009
A role for CMV infection in expansion of dysfunctional IL-7 receptor alpha low memory CD8+ T cell with aging. (83.11)
Lee W, Kang S, Lee S, Shah K, Kang I. A role for CMV infection in expansion of dysfunctional IL-7 receptor alpha low memory CD8+ T cell with aging. (83.11). The Journal Of Immunology 2009, 182: 83.11-83.11. DOI: 10.4049/jimmunol.182.supp.83.11.Peer-Reviewed Original ResearchLeukocyte Ig-like receptor-1Memory CD8T cellsAge-associated expansionCMV infectionChronic persistent viral infectionIL-7 receptor alpha chainT cell receptor repertoireHuman memory CD8TCR-mediated proliferationPersistent viral infectionCell receptor repertoireIg-like receptor-1Receptor alpha chainCytomegalovirus infectionIL-15Receptor beta chainElderly donorsCD8Young donorsViral infectionReceptor repertoireReceptor 1CMVExpression correlates