2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2010
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss
Kim T, Ha H, Kim N, Park E, Rho J, Kim E, Lorenzo J, Choi Y, Lee S. ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss. Biochemical And Biophysical Research Communications 2010, 403: 73-78. PMID: 21040703, PMCID: PMC3026595, DOI: 10.1016/j.bbrc.2010.10.117.Peer-Reviewed Original ResearchConceptsColony forming unit-granulocyte/macrophageBone lossActions of bone-forming osteoblastsOsteoclast maturationOvariectomy (OVX)-induced bone lossOVX-induced bone lossBone homeostasisOVX-induced increaseIncreased bone resorptionBone marrow cellsOsteoclast formation in vitroExcessive bone lossPathological conditionsNormal developmentBone-forming osteoblastsBone-resorbing osteoclastsControl of bone homeostasisMarrow cellsBone massProtect miceBone resorptionFormation in vitroOsteoclast differentiationOsteoclast precursorsAtp6v0d2
2008
Corrigendum to “NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival” [Biochem. Biophys. Res. Commun. 369 (2008) 320–326]
Lee S, Kim T, Park E, Yang S, Jeong D, Choi Y, Rho J. Corrigendum to “NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival” [Biochem. Biophys. Res. Commun. 369 (2008) 320–326]. Biochemical And Biophysical Research Communications 2008, 373: 174. DOI: 10.1016/j.bbrc.2008.06.005.Peer-Reviewed Original ResearchNHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival
Lee S, Kim T, Park E, Yang S, Jeong D, Choi Y, Rho J. NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival. Biochemical And Biophysical Research Communications 2008, 369: 320-326. PMID: 18269914, DOI: 10.1016/j.bbrc.2008.01.168.Peer-Reviewed Original ResearchConceptsFull-length cDNANa(+)/H(+) exchangerIsolated full-length cDNAsMembrane-spanning domainsNa(+)/H(+) exchanger familyGene expression profilesResponse to receptor activationGene candidatesOC differentiationCDNA microarrayNa+/H+ exchanger familyClonesLigand signalingFunctional roleCDNAAction of osteoblastsRegulates osteoclast differentiationGenesReceptor activationOsteoclast differentiationBone homeostasisDifferentiationBalanced actionOsteoclastsSurvival