2012
D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1
Yu J, Choi S, Park E, Shin B, Yu J, Lee S, Takami M, Kang J, Meong H, Rho J. D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. Journal Of Clinical Immunology 2012, 32: 1360-1371. PMID: 22711011, DOI: 10.1007/s10875-012-9722-z.Peer-Reviewed Original ResearchConceptsTartrate-resistant acid phosphataseEffect of D-chiro-inositolOC differentiationD-chiro-inositolExpression of OC marker genesNuclear factor of activated T cells c1Inflammatory bone lossCell-cell fusionAccelerated bone destructionDose-dependent mannerExpression of NFATc1Formation of multinucleated osteoclastsBone-related diseasesMultinucleated giant cellsSecondary osteoporosisCell fusion assayOsteoclastogenic genesBone destructionBone lossDiabetes mellitusOC precursorsGiant cellsOC formationMultinucleated osteoclastsNFATc1
2010
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss
Kim T, Ha H, Kim N, Park E, Rho J, Kim E, Lorenzo J, Choi Y, Lee S. ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss. Biochemical And Biophysical Research Communications 2010, 403: 73-78. PMID: 21040703, PMCID: PMC3026595, DOI: 10.1016/j.bbrc.2010.10.117.Peer-Reviewed Original ResearchConceptsColony forming unit-granulocyte/macrophageBone lossActions of bone-forming osteoblastsOsteoclast maturationOvariectomy (OVX)-induced bone lossOVX-induced bone lossBone homeostasisOVX-induced increaseIncreased bone resorptionBone marrow cellsOsteoclast formation in vitroExcessive bone lossPathological conditionsNormal developmentBone-forming osteoblastsBone-resorbing osteoclastsControl of bone homeostasisMarrow cellsBone massProtect miceBone resorptionFormation in vitroOsteoclast differentiationOsteoclast precursorsAtp6v0d2