Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
Esterhuyse M, Weiner J, Caron E, Loxton A, Iannaccone M, Wagman C, Saikali P, Stanley K, Wolski W, Mollenkopf H, Schick M, Aebersold R, Linhart H, Walzl G, Kaufmann S. Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers. MBio 2015, 6: 10.1128/mbio.01187-15. PMID: 26374119, PMCID: PMC4600108, DOI: 10.1128/mbio.01187-15.Peer-Reviewed Original ResearchConceptsTB patientsPilot studyActive tuberculosis diseaseLarge-scale studiesSpread of TBLTBI controlLTBI participantsTuberculosis infectionTuberculosis diseaseDisease progressionHealthy controlsPrognostic biomarkerImmune responseBiologic mechanismsHealthy individualsPatientsHost responseInfected individualsBetter careInfectious diseasesMycobacterium tuberculosisSmall sample sizeBiomarker developmentRegulation of functionDNA methylation