2023
Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBlood PressureChildChild, HospitalizedHumansHypertensionRetrospective StudiesConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntihypertensive AgentsBlood PressureHumansHypertensionHypotensionRetrospective StudiesConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsRetinal vein occlusion is associated with stroke independent of underlying cardiovascular disease
Bakhoum C, Madala S, Long C, Adabifirouzjaei F, Freeman W, Goldbaum M, DeMaria A, Bakhoum M. Retinal vein occlusion is associated with stroke independent of underlying cardiovascular disease. Eye 2022, 37: 764-767. PMID: 35411111, PMCID: PMC9998396, DOI: 10.1038/s41433-022-02038-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCross-Sectional StudiesHumansHypertensionRetinal Vein OcclusionRisk FactorsStrokeConceptsRetinal vein occlusionPresence of RVORisk of strokeCardiovascular diseaseOdds ratioVein occlusionRisk factorsMultivariable logistic regression modelCoronary artery diseaseCross-sectional studyYears of ageLogistic regression modelsArtery diseaseDiabetes mellitusCarotid diseaseStroke developmentAtrial fibrillationLeading causeYoung subjectsEarly interventionStrokeOlder individualsConclusionsOur findingsDiseaseRiskScreening for Hypertension in Children With and Without Autism Spectrum Disorder
Nugent JT, Bakhoum C, Ghazi L, Greenberg JH. Screening for Hypertension in Children With and Without Autism Spectrum Disorder. JAMA Network Open 2022, 5: e226246. PMID: 35385092, PMCID: PMC8987909, DOI: 10.1001/jamanetworkopen.2022.6246.Peer-Reviewed Original Research
2021
Proteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents
Bakhoum CY, Vuong KT, Carter CE, Gabbai FB, Ix JH, Garimella PS. Proteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents. Pediatric Research 2021, 90: 876-881. PMID: 33504962, PMCID: PMC8313642, DOI: 10.1038/s41390-020-01315-3.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringBody mass indexAssociation of proteinuriaBlood pressureRisk factorsUrine PCRNocturnal blood pressure dippingKidney function declineNocturnal blood pressureAdverse cardiovascular outcomesElevated blood pressureModifiable risk factorsDiastolic blood pressureGlomerular filtration rateBlood pressure dippingBlood pressure monitoringSpot urine proteinHypertensive childrenImpactOur studyCardiovascular outcomesCreatinine ratioFunction declineMass indexProspective studyUrine protein
2020
The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial
Bakhoum CY, Anderson CAM, Juraschek SP, Rebholz CM, Appel LJ, Miller ER, Parikh CR, Obeid W, Rifkin DE, Ix JH, Garimella PS. The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial. American Journal Of Hypertension 2020, 34: 154-156. PMID: 32856709, PMCID: PMC7951043, DOI: 10.1093/ajh/hpaa140.Peer-Reviewed Original ResearchConceptsSystolic blood pressureUrine uromodulinUromodulin levelsBlood pressureSodium dietSalt intakeDASH-Sodium trialHigh sodium dietHigh salt intakeHigh-salt dietSalt-induced hypertensionBlood pressure changesBody mass indexMultivariable linear regressionLoop of HenleHigher baseline levelsThick ascending limbFeeding periodGreater increaseSodium trialSalt dietDietary ApproachesMass indexRandomized trialsSBP change