2022
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity 2022, 55: 1609-1626.e7. PMID: 35963236, PMCID: PMC9474643, DOI: 10.1016/j.immuni.2022.07.007.Peer-Reviewed Original ResearchConceptsToll-like receptor 4ISG inductionMatricellular proteinPro-inflammatory phenotypeAnti-inflammatory macrophagesInterferon-stimulated gene expressionAdipocyte-specific deletionInhibition of glycolysisImmunometabolic adaptationsMyD88 pathwayReceptor 4Chronic diseasesFunctional declineCaloric restrictionInterferon responseHealth spanMacrophagesInflammationMitochondrial respirationSPARCInductionGene expressionAdipokinesObesityIFN
2009
Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic Autoimmunity
Wang A, Mohan C, Wakeland E. Chapter 44 Genetic Susceptibility to Kidney Disease as a Consequence of Systemic Autoimmunity. 2009, 737-748. DOI: 10.1016/b978-0-12-449851-8.00044-9.Peer-Reviewed Original ResearchLupus nephritisImmune complexesClass V lupus nephritisSystemic lupus erythematosus diseaseMembranous proliferative glomerulonephritisSevere kidney pathologyWhite SLE patientsContinuum of diseaseGlomerular capillary wallPathogenic autoimmunityRenal insufficiencySLE patientsKidney diseaseSerum concentrationsProliferative glomerulonephritisSystemic autoimmunityDisease progressionChronic diseasesKidney pathologyGlomerular scarringNephritisSLE susceptibilityRole of geneticsClass IIIC1q component