Andrew J. Hudak
About
Research
Publications
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes
Bhagchandani S, Ehrenzeller S, Pires I, Chaudhary N, Booth C, Kwon D, Koutsioumpa C, Baker C, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper W, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Science Immunology 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.
2025
Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice
Moriyama M, Rodrigues G, Wang J, Jayewickreme R, Hudak A, Dong H, Homer R, Ma S, Iwasaki A. Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2422171122. PMID: 40991437, PMCID: PMC12501169, DOI: 10.1073/pnas.2422171122.Peer-Reviewed Original ResearchIntestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
Bachtel N, Cullen J, Liu M, Erickson S, Kutyavin V, El-Naccache D, Florsheim E, Lim J, Sullivan Z, Imaeda R, Hudak A, Zhang C, Medzhitov R. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens. Science 2025, 389: eadp0246-eadp0246. PMID: 40773543, PMCID: PMC12513082, DOI: 10.1126/science.adp0246.Peer-Reviewed Original Research
2023
Remodeling of colon plasma cell repertoire within ulcerative colitis patients
Scheid J, Eraslan B, Hudak A, Brown E, Sergio D, Delorey T, Phillips D, Lefkovith A, Jess A, Duck L, Elson C, Vlamakis H, Plichta D, Deguine J, Ananthakrishnan A, Graham D, Regev A, Xavier R. Remodeling of colon plasma cell repertoire within ulcerative colitis patients. Journal Of Experimental Medicine 2023, 220: e20220538. PMID: 36752797, PMCID: PMC9949229, DOI: 10.1084/jem.20220538.Peer-Reviewed Original Research