The local microenvironment drives activation of neutrophils in human brain tumors
Maas R, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado Á, Marie D, Lilja J, Marcone R, Calvo G, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger A, Brouland J, Daniel R, Hegi M, Joyce J. The local microenvironment drives activation of neutrophils in human brain tumors. Cell 2023, 186: 4546-4566.e27. PMID: 37769657, DOI: 10.1016/j.cell.2023.08.043.Peer-Reviewed Original ResearchTumor-associated neutrophilsHuman brain tumorsBrain tumorsTumor necrosis factor alphaDistinct inflammatory signatureOverall immune suppressionBrain metastasis patientsPro-inflammatory mediatorsSoluble inflammatory mediatorsAbundant immune cellsNecrosis factor alphaActivation of neutrophilsTumor-associated macrophagesPro-angiogenic capacityBrain metastasesInflammatory signatureMetastasis patientsInflammatory mediatorsNeutrophil phenotypeImmune suppressionPeripheral bloodBlood neutrophilsDifferent cancer typesImmune cellsBrain microenvironment