2021
Viral interference cannot be concluded from datasets containing only symptomatic patients – Authors' reply
Wu A, Mihaylova VT, Landry ML, Foxman EF. Viral interference cannot be concluded from datasets containing only symptomatic patients – Authors' reply. The Lancet Microbe 2021, 2: e10. PMID: 35544223, DOI: 10.1016/s2666-5247(20)30218-4.Peer-Reviewed Original Research
2020
Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study
Wu A, Mihaylova VT, Landry ML, Foxman EF. Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study. The Lancet Microbe 2020, 1: e254-e262. PMID: 33103132, PMCID: PMC7580833, DOI: 10.1016/s2666-5247(20)30114-2.Peer-Reviewed Original ResearchConceptsRhinovirus infectionInterferon-stimulated genesExperimental infection studiesClinical data analysisMock infectionInfection studiesDay 3ISG expressionViral interferenceInterferon responsePrimary human airway epithelial culturesYale-New Haven HospitalHuman airway epithelial culturesIAV RNASeasonal influenza epidemicsNational InstituteAirway epithelial culturesReverse transcription-quantitative PCRTranscription-quantitative PCRElectronic medical record systemPeak virusAirway mucosaMedical record systemRespiratory virusesIAV infectionInterindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture
Villa M, Bloom R, Silverman J, Durand H, Jiang S, Wu A, Dallow E, Huang S, You L, David L. Interindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture. MSystems 2020, 5: 10.1128/msystems.00864-19. PMID: 32606031, PMCID: PMC7329328, DOI: 10.1128/msystems.00864-19.Peer-Reviewed Original ResearchBacterial taxaGut bacterial taxaMicrobiota membersGut bacteriaHigh-throughput DNA sequencingHuman gut microbial communityIndividual microbiota membersFunction of hundredsIndividual bacterial taxaGut microbial communityGut bacterial speciesBasic microbiological researchLevels of richnessCommunity diversityMicrobial functionsMicrobial communitiesMultiple polysaccharidesTaxaMicrobiota ecologyBacterial speciesMicrobiota-directed therapiesSimilar abundanceMicrobiological researchDNA sequencingDietary polysaccharides
2019
A suite of automated sequence analyses reduces the number of candidate deleterious variants and reveals a difference between probands and unaffected siblings
Gu F, Wu A, Gordon M, Vlahos L, Macnamara S, Burke E, Malicdan M, Adams D, Tifft C, Toro C, Gahl W, Markello T. A suite of automated sequence analyses reduces the number of candidate deleterious variants and reveals a difference between probands and unaffected siblings. Genetics In Medicine 2019, 21: 1772-1780. PMID: 30700791, PMCID: PMC6669106, DOI: 10.1038/s41436-019-0434-0.Peer-Reviewed Original Research
2018
Microbial nitrogen limitation in the mammalian large intestine
Reese A, Pereira F, Schintlmeister A, Berry D, Wagner M, Hale L, Wu A, Jiang S, Durand H, Zhou X, Premont R, Diehl A, O’Connell T, Alberts S, Kartzinel T, Pringle R, Dunn R, Wright J, David L. Microbial nitrogen limitation in the mammalian large intestine. Nature Microbiology 2018, 3: 1441-1450. PMID: 30374168, PMCID: PMC6264799, DOI: 10.1038/s41564-018-0267-7.Peer-Reviewed Original ResearchConceptsNitrogen limitationMicrobial nitrogen limitationHost-microbe interactionsGut microbial ecosystemMicrobial symbiontsHost useEcological communitiesMicrobial communitiesMammal speciesCommensal taxaPhylum BacteroidetesNitrogen availabilityDietary nutrientsMammalian large intestineResource limitationsNitrogen supplyTotal nitrogen supplyProtein levelsResource supplyCommensal microbiotaMicrobiomeLarge intestineGerm-free miceExcess dietary proteinHost