2020
Interindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture
Villa M, Bloom R, Silverman J, Durand H, Jiang S, Wu A, Dallow E, Huang S, You L, David L. Interindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture. MSystems 2020, 5: 10.1128/msystems.00864-19. PMID: 32606031, PMCID: PMC7329328, DOI: 10.1128/msystems.00864-19.Peer-Reviewed Original ResearchBacterial taxaGut bacterial taxaMicrobiota membersGut bacteriaHigh-throughput DNA sequencingHuman gut microbial communityIndividual microbiota membersFunction of hundredsIndividual bacterial taxaGut microbial communityGut bacterial speciesBasic microbiological researchLevels of richnessCommunity diversityMicrobial functionsMicrobial communitiesMultiple polysaccharidesTaxaMicrobiota ecologyBacterial speciesMicrobiota-directed therapiesSimilar abundanceMicrobiological researchDNA sequencingDietary polysaccharides
2018
Microbial nitrogen limitation in the mammalian large intestine
Reese A, Pereira F, Schintlmeister A, Berry D, Wagner M, Hale L, Wu A, Jiang S, Durand H, Zhou X, Premont R, Diehl A, O’Connell T, Alberts S, Kartzinel T, Pringle R, Dunn R, Wright J, David L. Microbial nitrogen limitation in the mammalian large intestine. Nature Microbiology 2018, 3: 1441-1450. PMID: 30374168, PMCID: PMC6264799, DOI: 10.1038/s41564-018-0267-7.Peer-Reviewed Original ResearchConceptsNitrogen limitationMicrobial nitrogen limitationHost-microbe interactionsGut microbial ecosystemMicrobial symbiontsHost useEcological communitiesMicrobial communitiesMammal speciesCommensal taxaPhylum BacteroidetesNitrogen availabilityDietary nutrientsMammalian large intestineResource limitationsNitrogen supplyTotal nitrogen supplyProtein levelsResource supplyCommensal microbiotaMicrobiomeLarge intestineGerm-free miceExcess dietary proteinHost