2006
Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study
Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL. Decreased Numbers of Regulatory T Cells Suggest Impaired Immune Tolerance in Children with Tourette Syndrome: A Preliminary Study. Biological Psychiatry 2006, 61: 273-278. PMID: 16996487, DOI: 10.1016/j.biopsych.2006.06.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAntigens, CDAntigens, Differentiation, T-LymphocyteAutoantigensBlood Cell CountCD4 Lymphocyte CountCD8-Positive T-LymphocytesChildData Interpretation, StatisticalFemaleFlow CytometryHumansImmune ToleranceInterleukin-2 Receptor alpha SubunitLectins, C-TypeLymphocyte CountMaleStreptococcal InfectionsTic DisordersT-LymphocytesTourette SyndromeConceptsT reg cellsRegulatory T cellsReg cellsTourette syndromeT cellsTS patientsFluorescence-activated cell sortingHealthy age-matched control childrenHealthy age-matched control subjectsT reg cell numbersBeta-hemolytic streptococcal infectionAge-matched control subjectsHost T-cell immunityPathogenesis of TSHemolytic streptococcal infectionT cell immunitySignificant decreaseAge-matched control childrenAutoimmune inflammationCell immunityStreptococcal infectionAutoreactive lymphocytesImmune toleranceAutoimmune responsePeripheral blood
2003
Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA1
Geirsson A, Paliwal I, Lynch RJ, Bothwell AL, Hammond GL. Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA1. Transplantation 2003, 76: 387-394. PMID: 12883198, DOI: 10.1097/01.tp.0000073612.04525.46.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceDNA MethylationDNA, ComplementaryHeLa CellsHumansLuciferasesMajor Histocompatibility ComplexMolecular Sequence DataNuclear ProteinsNucleic Acid ConformationPromoter Regions, GeneticProtein Structure, TertiaryRNA, UntranslatedSuppression, GeneticTrans-ActivatorsTranscription, GeneticTransfectionTrophoblastsConceptsClass II expressionMHC class IICIITA promoter IVPromoter IVQuantitative polymerase chain reactionMajor histocompatibility complexAllograft tolerancePolymerase chain reactionFluorescence-activated cell sortingCIITA expressionHuman leukocyte antigen-DRClass IIMHC class II expressionClassic major histocompatibility complexChain reactionCell sortingPurposes of transplantationLack expressionHistocompatibility complexNoncoding RNAsII-deficient cellsSelective suppressionPromoter-reporter constructsCIITA promoterInhibitory domain