2016
Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma
Chae WJ, Bothwell AL. Snapshots of CD4 + T cell plasticity in the pathogenesis of allergic asthma. Journal Of Thoracic Disease 2016, 8: e1010-e1012. PMID: 27747048, PMCID: PMC5059289, DOI: 10.21037/jtd.2016.08.19.Peer-Reviewed Original ResearchThymic stromal lymphopoietinHouse dust miteAllergic asthmaDendritic cellsType 2 inflammatory diseasesT helper type 2 cellsNaïve CD4 T cellsCD4 T cellsHumoral immune responseTh2 effector cellsT cell plasticityType 2 cellsLung epithelial cellsIL-25Lung eosinophiliaIL-33Effector cellsEnvironmental allergensTh2 cytokinesDust miteInflammatory diseasesT cellsImmune responseB cellsEpithelial cells
2007
Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription
Muthukumarana P, Chae WJ, Maher S, Rosengard BR, Bothwell AL, Metcalfe SM. Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription. Transplantation 2007, 84: s6-s11. PMID: 17632414, DOI: 10.1097/01.tp.0000269116.06510.db.Peer-Reviewed Original ResearchConceptsExpression of Foxp3Wt-Foxp3Regulatory transplantation toleranceSOCS-3Immune effector cellsStem cell-related factorsHuman T cell lineCell-related factorsT cell linesJurkat human T cell lineSOCS-3 transcriptsLIF transcriptionSuppressor of cytokineTransplantation toleranceEffector cellsT lymphocytesFoxp3Inhibitory factorKey mediatorT cell signal transductionAxotrophinTregsFurther evidenceTranscriptional activityRegulatory role
2004
Interferon α but Not Interleukin 12 Activates STAT4 Signaling in Human Vascular Endothelial Cells*
Torpey N, Maher SE, Bothwell AL, Pober JS. Interferon α but Not Interleukin 12 Activates STAT4 Signaling in Human Vascular Endothelial Cells*. Journal Of Biological Chemistry 2004, 279: 26789-26796. PMID: 15087447, DOI: 10.1074/jbc.m401517200.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorCells, CulturedChemokine CCL2DNADNA, ComplementaryDNA-Binding ProteinsDose-Response Relationship, DrugEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryHumansImmunoblottingInflammationInterferon-alphaInterleukin-12Oligonucleotide Array Sequence AnalysisPhosphorylationPrecipitin TestsProtein Structure, TertiaryRecombinant ProteinsRepressor ProteinsRetroviridaeReverse Transcriptase Polymerase Chain ReactionRNARNA, MessengerSignal TransductionSTAT4 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsTime FactorsTrans-ActivatorsTranscription FactorsUmbilical VeinsUp-RegulationConceptsHuman umbilical vein ECMonocyte chemoattractant protein-1Quantitative RT-PCRVascular endothelial cellsEndothelial cellsChemokine monocyte chemoattractant protein-1Chemoattractant protein-1Cultured human umbilical vein endothelial cellsPro-inflammatory behaviorIFNalpha responseHuman vascular endothelial cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsNeuroblastoma cell linesSuppressor of cytokineVein endothelial cellsEffector cellsInterleukin-12T cellsSTAT4 pathwayInterferon αIL12 receptorCytokinesU3A cellsRT-PCR