2023
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival
Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossHuman leukocyte antigenExpression quantitative trait lociT cellsTGF-β1TGF-β1/Smad pathwayDonor-recipient differencesKidney allograft lossChronic allograft rejectionKidney transplant survivalDonor-recipient mismatchActive TGF-β1Allograft lossGraft lossAllograft rejectionTransplant cohortPeripheral bloodLeukocyte antigenClinical trialsImmune cellsHaplotype mismatchGenome-wide scaleTransplant survivalQuantitative trait lociSingle nucleotide polymorphism data
2020
Analysis of DNA Methylation Changes in Mice Mediated by Early‐life Exposure to the Antidepressant S‐citalopram
Rodriquez M, Shetty M, Black E, Kretschmar M, Perley D, De Kumar B, Henry L. Analysis of DNA Methylation Changes in Mice Mediated by Early‐life Exposure to the Antidepressant S‐citalopram. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.06398.Peer-Reviewed Original ResearchMethylation changesSelective serotonin reuptake inhibitorsGenome-wide scaleDNA methylation changesSingle amino acid substitutionDNA methylation analysisSpecific methylation changesAmino acid substitutionsExpression changesMolecular mechanismsAcid substitutionsMethylation analysisSerotonin transporter blockadeSerotonin reuptake inhibitorsEarly life exposurePost-analysis methodsEarly developmentMice MediatedTransgenic miceReuptake inhibitorsTransporter blockadeMale miceS-citalopramSerotonin transporterSignificant risk