Themis Kyriakides, PhD

• Carlos Fernandez-Hernando
• Francis Lee
• Henry C. Hsia
• Hitten Zaveri
• Jordan Pober
• Julie Goodwin
• Nikhil S. Malvankar
• Raimund Herzog
• Xinshou Ouyang

Cell Fusion; Education, Medical; Extracellular Matrix; Foreign Bodies; Inflammation; Pathology; Wound Healing; Animal Experimentation; Nanomedicine; Translational Research, Biomedical

• Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesBracaglia L, Kyriakides T. Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies. Tissue Engineering Part B Reviews 2023, 29: 189-189. DOI: 10.1089/ten.teb.2023.29018.cfp.
• Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration StrategiesBracaglia L, Kyriakides T. Call for Papers: Special Issue on Modulation of the Immune System to Improve Tissue Regeneration Strategies. Tissue Engineering Part C Methods 2023 PMID: 37222726, DOI: 10.1089/tec.2023.29038.cfp.
• Author Correction: Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunctionXing H, Huang Y, Kunkemoeller B, Dahl P, Muraleetharan O, Malvankar N, Murrell M, Kyriakides T. Author Correction: Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction. Scientific Reports 2023, 13: 4253. PMID: 36918662, PMCID: PMC10015071, DOI: 10.1038/s41598-023-31191-w.
• Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunctionXing H, Huang Y, Kunkemoeller B, Dahl P, Muraleetharan O, Malvankar N, Murrell M, Kyriakides T. Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction. Scientific Reports 2022, 12: 22474. PMID: 36577792, PMCID: PMC9797577, DOI: 10.1038/s41598-022-26337-1.
• Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive InflammationKwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.
• Foreign body response to synthetic polymer biomaterials and the role of adaptive immunityKyriakides TR, Kim HJ, Zheng C, Harkins L, Tao W, Deschenes E. Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity. Biomedical Materials 2022, 17: 022007. PMID: 35168213, PMCID: PMC9159526, DOI: 10.1088/1748-605x/ac5574.
• Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cellsDash BC, Duan K, Kyriakides TR, Hsia HC. Integrin β3 targeting biomaterial preferentially promotes secretion of bFGF and viability of iPSC-derived vascular smooth muscle cells. Biomaterials Science 2021, 9: 5319-5329. PMID: 34190227, DOI: 10.1039/d1bm00162k.
• Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritisKwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.
• Biocompatibility of platinum-based bulk metallic glass in orthopedic applicationsLoye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications. Biomedical Materials 2021, 16: 045018. PMID: 33873168, DOI: 10.1088/1748-605x/abf981.
• Biocompatibility of nanomaterials and their immunological propertiesKyriakides TR, Raj A, Tseng TH, Xiao H, Nguyen R, Mohammed FS, Halder S, Xu M, Wu MJ, Bao S, Sheu WC. Biocompatibility of nanomaterials and their immunological properties. Biomedical Materials 2021, 16: 042005. PMID: 33578402, PMCID: PMC8357854, DOI: 10.1088/1748-605x/abe5fa.
• Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathwayLiu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway. Angiogenesis 2021, 24: 631-645. PMID: 33650028, PMCID: PMC8292305, DOI: 10.1007/s10456-021-09773-x.
• Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infectionCahill SV, Kwon H, Back J, Lee I, Lee S, Alder KD, Hao Z, Yu KE, Dussik CM, Kyriakides T, Lee F. Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. Journal Of Orthopaedic Research® 2021, 39: 402-414. PMID: 33336805, DOI: 10.1002/jor.24965.
• An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cellsDash BC, Duan K, Xing H, Kyriakides TR, Hsia HC. An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells. Biotechnology And Bioengineering 2020, 117: 3912-3923. PMID: 32770746, DOI: 10.1002/bit.27530.
• The role of extracellular matrix in the pathophysiology of diabetic woundsHuang Y, Kyriakides TR. The role of extracellular matrix in the pathophysiology of diabetic wounds. Matrix Biology Plus 2020, 6: 100037. PMID: 33543031, PMCID: PMC7852307, DOI: 10.1016/j.mbplus.2020.100037.
• Glycocalyx‐Like Hydrogel Coatings for Small Diameter Vascular GraftsDimitrievska S, Wang J, Lin T, Weyers A, Bai H, Qin L, Li G, Cai C, Kypson A, Kristofik N, Gard A, Sundaram S, Yamamoto K, Wu W, Zhao L, Kural M, Yuan Y, Madri J, Kyriakides T, Linhardt R, Niklason L. Glycocalyx‐Like Hydrogel Coatings for Small Diameter Vascular Grafts. Advanced Functional Materials 2020, 30 DOI: 10.1002/adfm.201908963.
• Chapter 16 Cell interactions with polymersSaltzman W, Kyriakides T. Chapter 16 Cell interactions with polymers. 2020, 275-293. DOI: 10.1016/b978-0-12-818422-6.00017-4.
• Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in DiabetesKunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR. Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes. Diabetes 2019, 68: 2016-2023. PMID: 31391172, PMCID: PMC6754242, DOI: 10.2337/db18-1001.
• The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodesFalcone JD, Sohal H, Kyriakides T, Bellamkonda RV. The impact of modulating the blood–brain barrier on the electrophysiological and histological outcomes of intracortical electrodes. Journal Of Neural Engineering 2019, 16: 046005. PMID: 31048574, DOI: 10.1088/1741-2552/ab1ef9.
• Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29Calabro NE, Barrett A, Chamorro-Jorganes A, Tam S, Kristofik NJ, Xing H, Loye AM, Sessa WC, Hansen K, Kyriakides TR. Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. Matrix Biology 2019, 82: 71-85. PMID: 30876926, PMCID: PMC6710120, DOI: 10.1016/j.matbio.2019.03.002.
• Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound HealingMorris AH, Lee H, Xing H, Stamer DK, Tan M, Kyriakides TR. Tunable Hydrogels Derived from Genetically Engineered Extracellular Matrix Accelerate Diabetic Wound Healing. ACS Applied Materials & Interfaces 2018, 10: 41892-41901. PMID: 30424595, PMCID: PMC9996546, DOI: 10.1021/acsami.8b08920.
• Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular ResponsesWang J, Loye A, Ketkaew J, Schroers J, Kyriakides T. Hierarchical Micro- and Nanopatterning of Metallic Glass to Engineer Cellular Responses. ACS Applied Bio Materials 2018, 1: 51-58. DOI: 10.1021/acsabm.8b00007.
• Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic GlassLoye AM, Kinser ER, Bensouda S, Shayan M, Davis R, Wang R, Chen Z, Schwarz UD, Schroers J, Kyriakides TR. Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass. Scientific Reports 2018, 8: 8758. PMID: 29884812, PMCID: PMC5993820, DOI: 10.1038/s41598-018-27098-6.
• Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in DiabetesKunkemoeller B, Kyriakides T. Elevated Thrombospondin‐2 Contributes to Delayed Wound Healing in Diabetes. The FASEB Journal 2018, 32: 414.3-414.3. DOI: 10.1096/fasebj.2018.32.1_supplement.414.3.
• Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic woundsMorris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR. Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds. Biomaterials 2018, 169: 61-71. PMID: 29631168, PMCID: PMC5933884, DOI: 10.1016/j.biomaterials.2018.03.049.
• Nanopatterned Bulk Metallic Glass BiosensorsKinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S, Legassey A, Loye A, Balestrini J, Solly DA, Schroers J, Taylor A, Papadimitrakopoulos F, Herzog RI, Kyriakides TR. Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors 2017, 2: 1779-1787. PMID: 29115132, DOI: 10.1021/acssensors.7b00455.
• Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrixKristofik NJ, Qin L, Calabro NE, Dimitrievska S, Li G, Tellides G, Niklason LE, Kyriakides TR. Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials 2017, 141: 63-73. PMID: 28667900, PMCID: PMC5918415, DOI: 10.1016/j.biomaterials.2017.06.025.
• A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delaminationBellini C, Kristofik NJ, Bersi MR, Kyriakides TR, Humphrey JD. A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delamination. Journal Of The Mechanical Behavior Of Biomedical Materials 2017, 71: 397-406. PMID: 28412645, PMCID: PMC8344363, DOI: 10.1016/j.jmbbm.2017.01.045.
• The host response to naturally-derived extracellular matrix biomaterialsMorris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Seminars In Immunology 2017, 29: 72-91. PMID: 28274693, DOI: 10.1016/j.smim.2017.01.002.
• Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.Kristofik N, Calabro NE, Tian W, Meng A, MacLauchlan S, Wang Y, Breuer CK, Tellides G, Niklason LE, Kyriakides TR. Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice. Blood 2016, 128: 1642-50. PMID: 27471233, PMCID: PMC5034742, DOI: 10.1182/blood-2016-03-702845.
• Emerging Technologies for Brain-Implantable DevicesLanning B, Joshi B, Kyriakides T, Spencer D, Zaveri H. Emerging Technologies for Brain-Implantable Devices. 2016, 429-441. DOI: 10.1201/b10866-39.
• Nanoparticle delivery of miR-223 to attenuate macrophage fusionMoore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR. Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 2016, 89: 127-135. PMID: 26967647, PMCID: PMC4924476, DOI: 10.1016/j.biomaterials.2016.02.036.
• Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sitesPapanna R, Mann LK, Tseng SC, Stewart RJ, Kaur SS, Swindle MM, Kyriakides TR, Tatevian N, Moise KJ. Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites. Placenta 2015, 36: 888-894. PMID: 26059341, PMCID: PMC4529759, DOI: 10.1016/j.placenta.2015.05.015.
• Chapter 5 Molecular Events at Tissue–Biomaterial InterfaceKyriakides T. Chapter 5 Molecular Events at Tissue–Biomaterial Interface. 2015, 81-116. DOI: 10.1016/b978-0-12-800196-7.00005-0.
• Engineering Cellular Response Using Nanopatterned Bulk Metallic GlassPadmanabhan J, Kinser ER, Stalter MA, Duncan-Lewis C, Balestrini JL, Sawyer AJ, Schroers J, Kyriakides TR. Engineering Cellular Response Using Nanopatterned Bulk Metallic Glass. ACS Nano 2014, 8: 4366-4375. PMID: 24724817, PMCID: PMC4046793, DOI: 10.1021/nn501874q.
• Chapter 20 Cell Interactions with PolymersSaltzman W, Kyriakides T. Chapter 20 Cell Interactions with Polymers. 2014, 385-406. DOI: 10.1016/b978-0-12-398358-9.00020-3.
• 715: Cryopreserved human amniotic membrane (hAM) with underwater adhesive coacervates (UAC) to seal and promote healing of iatrogenic fetal membrane defect site in a swine modelPapanna R, Mann L, Tseng S, Stewart R, Kaur S, Swindle M, Argoti P, Garcia E, Tatevian N, Buhimschi I, Kyriakides T, Moise K. 715: Cryopreserved human amniotic membrane (hAM) with underwater adhesive coacervates (UAC) to seal and promote healing of iatrogenic fetal membrane defect site in a swine model. American Journal Of Obstetrics And Gynecology 2014, 210: s351. DOI: 10.1016/j.ajog.2013.10.748.
• 447: Amniochorion apoptosis and autophagy: novel insights into the mechanisms of PPROM after fetoscopic laser surgery (FLS) for twin twin transfusion syndrome (TTTS)Papanna R, Mann L, Moise K, Kyriakides T, Zhao G, Argoti P, Buhimschi C, Buhimschi I. 447: Amniochorion apoptosis and autophagy: novel insights into the mechanisms of PPROM after fetoscopic laser surgery (FLS) for twin twin transfusion syndrome (TTTS). American Journal Of Obstetrics And Gynecology 2013, 208: s195. DOI: 10.1016/j.ajog.2012.10.613.
• Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body responseMalik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20095-20100. PMID: 22109549, PMCID: PMC3250158, DOI: 10.1073/pnas.1105152108.
• Bulk metallic glasses for biomedical applicationsSchroers J, Kumar G, Hodges T, Chan S, Kyriakides T. Bulk metallic glasses for biomedical applications. JOM 2009, 61: 21-29. DOI: 10.1007/s11837-009-0128-1.
• Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue EngineeringJay S, Shepherd B, Andrejecsk J, Kyriakides T, Pober J, Saltzman W. Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue Engineering. 2009, 1: 1-2. DOI: 10.1109/nebc.2009.4967788.
• Abstract 3594: Nogo-B is Essential for Macrophage Dependent Inflammatory Arteriogenesis and AngiogenesisYu J, Fernandez-Hernando C, Suarez Y, Suarez Y, Schleicher M, Hao Z, Wright P, Kyriakides T, Sessa W. Abstract 3594: Nogo-B is Essential for Macrophage Dependent Inflammatory Arteriogenesis and Angiogenesis. Circulation 2008, 118 DOI: 10.1161/circ.118.suppl_18.s_447-c.
• Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodelinglei L, Liu D, Huang Y, Jovin I, Shai S, Kyriakides T, Ross R, Giordano F. Endothelial Expression of Beta‐1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling. The FASEB Journal 2008, 22: 1122.11-1122.11. DOI: 10.1096/fasebj.22.1_supplement.1122.11.
• Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesisKyriakides T, Krady M, Zeng J, Skokos E. Thrombospondin 2 deficiency influences extracellular matrix assembly leading to increased ischemia‐induced angiogenesis and arteriogenesis. The FASEB Journal 2007, 21: a529-a529. DOI: 10.1096/fasebj.21.5.a529-a.
• Thrombospondin says no to NOKyriakides T. Thrombospondin says no to NO. Blood 2007, 109: 1793-1793. DOI: 10.1182/blood-2006-12-061978.
• Chapter Twenty Cell Interactions with PolymersSaltzman W, Kyriakides T. Chapter Twenty Cell Interactions with Polymers. 2007, 279-296. DOI: 10.1016/b978-012370615-7/50024-x.
• Enhanced recovery from ischemia in thrombospondin_2_null miceKrady M, Zeng J, Kyriakides T. Enhanced recovery from ischemia in thrombospondin_2_null mice. Matrix Biology 2006, 25: s58-s59. DOI: 10.1016/j.matbio.2006.08.162.
• Corrigendum to “The role of Thrombospondins 1 and 2 in the regulation of cell–matrix interaction, collagen fibril formation and the response to injury”Bornstein P, Agah A, Kyriakides T. Corrigendum to “The role of Thrombospondins 1 and 2 in the regulation of cell–matrix interaction, collagen fibril formation and the response to injury”. The International Journal Of Biochemistry & Cell Biology 2005, 37: 239-240. DOI: 10.1016/j.biocel.2004.05.015.
• The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell FormationKyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark-Lewis I, Rollins BJ, Bornstein P. The CC Chemokine Ligand, CCL2/MCP1, Participates in Macrophage Fusion and Foreign Body Giant Cell Formation. American Journal Of Pathology 2004, 165: 2157-2166. PMID: 15579457, PMCID: PMC1618731, DOI: 10.1016/s0002-9440(10)63265-8.
• MMP2-DEPENDENT PROTEOLYSIS OF EXTRACELLULAR MATRICES IN THROMBOSPONDIN 2-NULL MICE CONTRIBUTES TO A BLEEDING DIATHESISKyriakides T, Agah A, Hartzel T, Brooks P, Bornstein P. MMP2-DEPENDENT PROTEOLYSIS OF EXTRACELLULAR MATRICES IN THROMBOSPONDIN 2-NULL MICE CONTRIBUTES TO A BLEEDING DIATHESIS. Cardiovascular Pathology 2004, 13: 80. DOI: 10.1016/j.carpath.2004.03.237.
• Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bornstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. The American Journal Of Pathology 2003, 162: 627-35. PMID: 12547720, PMCID: PMC1851143, DOI: 10.1016/S0002-9440(10)63856-4.
• Design of “Smart” polymers that can ­direct intracellular drug deliveryHoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Design of “Smart” polymers that can ­direct intracellular drug delivery. Polymers For Advanced Technologies 2002, 13: 992-999. DOI: 10.1002/pat.232.
• Bioinspired Engineering of Intelligent Drug Delivery Systems and Protein– Polymer ConjugatesStayton P, Hoffman A, Press O, Murthy N, Lackey C, Cheung C, Shimoboji T, Ding Z, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Bioinspired Engineering of Intelligent Drug Delivery Systems and Protein– Polymer Conjugates. 2002 DOI: 10.1201/9780203908976.ch15.
• Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null MiceKyriakides T, Zhu Y, Yang Z, Huynh G, Bornstein P. Altered Extracellular Matrix Remodeling and Angiogenesis in Sponge Granulomas of Thrombospondin 2-Null Mice. American Journal Of Pathology 2001, 159: 1255-1262. PMID: 11583953, PMCID: PMC1850515, DOI: 10.1016/s0002-9440(10)62512-6.
• Correction: A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phaseMalek N, Sundberg H, McGrew S, Nakayama K, Kyriakides T, Roberts J. Correction: A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 2001, 413: 652-652. DOI: 10.1038/35098121.
• A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase.Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakides TR, Roberts JM. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 2001, 413: 323-7. PMID: 11565035, DOI: 10.1038/35095083.
• Bioinspired polymers that control intracellular drug deliveryHoffman A, Stayton P, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides T, Bornstein P. Bioinspired polymers that control intracellular drug delivery. Biotechnology And Bioprocess Engineering 2001, 6: 205-212. DOI: 10.1007/bf02931981.
• Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanismHawighorst T, Velasco P, Streit M, Hong Y, Kyriakides T, Brown L, Bornstein P, Detmar M. Thrombospondin‐2 plays a protective role in multistep carcinogenesis: a novel host anti‐tumor defense mechanism. The EMBO Journal 2001, 20: 2631-2640. PMID: 11387198, PMCID: PMC125494, DOI: 10.1093/emboj/20.11.2631.
• Regulation of Angiogenesis and Matrix Remodeling by Localized, Matrix-Mediated Antisense Gene DeliveryKyriakides T, Hartzel T, Huynh G, Bornstein P. Regulation of Angiogenesis and Matrix Remodeling by Localized, Matrix-Mediated Antisense Gene Delivery. Molecular Therapy 2001, 3: 842-849. PMID: 11407897, DOI: 10.1006/mthe.2001.0336.
• Thrombospondin 2, a matricellular protein with diverse functionsBornstein P, Armstrong L, Hankenson K, Kyriakides T, Yang Z. Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biology 2000, 19: 557-568. PMID: 11102746, DOI: 10.1016/s0945-053x(00)00104-9.
• Thrombospondin 2 Modulates Collagen Fibrillogenesis and AngiogenesisBornstein P, Kyriakides T, Yang Z, Armstrong L, Birk D. Thrombospondin 2 Modulates Collagen Fibrillogenesis and Angiogenesis. Journal Of Investigative Dermatology Symposium Proceedings 2000, 5: 61-66. PMID: 11147677, DOI: 10.1046/j.1087-0024.2000.00005.x.
• Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2Yang Z, Kyriakides T, Bornstein P. Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2. Molecular Biology Of The Cell 2000, 11: 3353-3364. PMID: 11029041, PMCID: PMC14997, DOI: 10.1091/mbc.11.10.3353.
• Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2Hankenson K, Bain S, Kyriakides T, Smith E, Goldstein S, Bornstein P. Increased Marrow‐Derived Osteoprogenitor Cells and Endosteal Bone Formation in Mice Lacking Thrombospondin 2. Journal Of Bone And Mineral Research 2000, 15: 851-862. PMID: 10804014, DOI: 10.1359/jbmr.2000.15.5.851.
• Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 GeneKyriakides T, Tam J, Bornstein P. Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene. Journal Of Investigative Dermatology 1999, 113: 782-787. PMID: 10571734, DOI: 10.1046/j.1523-1747.1999.00755.x.
• Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularityKyriakides T, Leach K, Hoffman A, Ratner B, Bornstein P. Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 4449-4454. PMID: 10200282, PMCID: PMC16352, DOI: 10.1073/pnas.96.8.4449.
• The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult MiceKyriakides T, Zhu Y, Yang Z, Bornstein P. The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice. Journal Of Histochemistry & Cytochemistry 1998, 46: 1007-1015. PMID: 9705966, DOI: 10.1177/002215549804600904.
• Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding DiathesisKyriakides T, Zhu Y, Smith L, Bain S, Yang Z, Lin M, Danielson K, Iozzo R, LaMarca M, McKinney C, Ginns E, Bornstein P. Mice That Lack Thrombospondin 2 Display Connective Tissue Abnormalities That Are Associated with Disordered Collagen Fibrillogenesis, an Increased Vascular Density, and a Bleeding Diathesis. Journal Of Cell Biology 1998, 140: 419-430. PMID: 9442117, PMCID: PMC2132586, DOI: 10.1083/jcb.140.2.419.
• Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivoHugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser W, Johnson R. Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney International 1995, 48: 1846-1856. PMID: 8587244, DOI: 10.1038/ki.1995.483.
• A nuclear juvenile hormone-binding protein from larvae of Manduca sexta: a putative receptor for the metamorphic action of juvenile hormone.Palli S, Touhara K, Charles J, Bonning B, Atkinson J, Trowell S, Hiruma K, Goodman W, Kyriakides T, Prestwich G. A nuclear juvenile hormone-binding protein from larvae of Manduca sexta: a putative receptor for the metamorphic action of juvenile hormone. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6191-6195. PMID: 8016136, PMCID: PMC44164, DOI: 10.1073/pnas.91.13.6191.
• Regulation and synthesis of selected bacteria-induced proteins in Manduca sextaSpence K, Karlinsey J, Kyriakides T, Patil C, Minnick M. Regulation and synthesis of selected bacteria-induced proteins in Manduca sexta. Insect Biochemistry And Molecular Biology 1992, 22: 321-331. DOI: 10.1016/0965-1748(92)90070-u.