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Naftali Kaminski, MD

Boehringer Ingelheim Pharmaceuticals, Inc. Professor of Medicine (Pulmonary); Section Chief, Pulmonary, Critical Care & Sleep Medicine

Research & Publications
Biography
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Research Summary

Dr. Kaminski’s research is focused on improving our understanding, diagnosis and treatment of advanced lung diseases such as Idiopathic Pulmonary Fibrosis (IPF), using a combination of cutting-edge high throughput profiling technologies, advanced systems biology and disease modeling approaches. Among the key discoveries of his lab are reproducible outcome predictive peripheral blood biomarkers such as MMP7 and the 52 gene signature in IPF, the role of microRNAs in pulmonary fibrosis, the role of phosphatases in pulmonary fibrosis, the potential therapeutic role of thyroid hormone mimetics in pulmonary fibrosis and ARDS and most recently the identification of novel cell populations in IPF using single-cell profiling technologies.

Extensive Research Description

Dr. Kaminski’s team main ambition is to uncover the mechanisms, and thus have a significant impact on the management of advanced lung diseases with a specific focus on IPF, a chronic progressive interstitial lung disease that is currently incurable. To study these mechanisms Dr. Kaminski’s team applies systems biology approaches that incorporate a combination of traditional molecular biology methods, high-throughput genomic technologies such as transcript level profiling (single cell RNA sequencing and epigenomic profiling ) , genome scale analyses of gene variants, advanced bioinformatics approaches and targeted proteomic approaches. These studies have led to shifts in the perception of pulmonary fibrosis, the realization that aberrant activation of developmental pathways is at the core of lung fibrosis, the discovery of the role of microRNAs in IPF, the identification and validation of novel prognostic biomarkers in the bloodstream, as well many additional insights.

Mechanisms of pulmonary fibrosis and other chronic lung diseases

Understanding and identifying the genetic and molecular networks that determine the lung phenotype using high throughput high resolution genomic and proteomic technologies.
Role of miRNA in advanced lung disease (IPF, Emphysema).
Role of other non-coding RNAs (lincRNAs) in advanced lung disease
The IPF Cell Atlas (www.IPFCellAtlas.com)
The Normal Aging Lung Cell Atlas
The Pulmonary Fibrosis Connectome
Epigenomics of chronic lung disease.
Using computational approaches to Integrate clinical, biological, genomic and proteomic data to identify new molecular phenotypes of disease.

New molecular targets in Pulmonary Fibrosis

The role and regulation of microRNAs (let-7, mir-33, mir-29) in human pulmonary fibrosis and development of microRNA inhibitors and agonist for therapeutic interventions
The role of large non-coding RNAs in pulmonary fibrosis
The role of thyroid hormone signaling in epithelial cell protection in fibrosis
Novel lung resident cell specific therapeutic approaches in pulmonary fibrosis

Biomarker Discovery and Validation in chronic and progressive lung disease

Approaches to the development of liquid biopsy in human pulmonary fibrosis and other interstitial lung disease
Peripheral blood protein markers in lung fibrosis
Genetic predictors of outcome in lung fibrosis
Peripheral blood gene expression changes and disease progression

Coauthors

Research Interests

Emphysema; Fibrosis; Genetics, Medical; Lung Diseases; RNA; Gene Expression; Genomics; MicroRNAs; Metalloproteases; Biomarkers, Pharmacological

Public Health Interests

Aging; Bioinformatics; Biomarkers; Genetics, Genomics, Epigenetics; Respiratory Disease/Infections; Pollution

Research Images

Thyroid Hormone effects on Mitochondria in Type II Epithelial Cells

Selected Publications

A lung targeted miR-29 mimic as a therapy for pulmonary fibrosisChioccioli M, Roy S, Newell R, Pestano L, Dickinson B, Rigby K, Herazo-Maya J, Jenkins G, Ian S, Saini G, Johnson SR, Braybrooke R, Yu G, Sauler M, Ahangari F, Ding S, DeIuliis J, Aurelien N, Montgomery RL, Kaminski N. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis EBioMedicine 2022, 85: 104304. PMID: 36265417, PMCID: PMC9587275, DOI: 10.1016/j.ebiom.2022.104304.
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosisJaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis Nature Communications 2022, 13: 5637. PMID: 36163190, PMCID: PMC9513076, DOI: 10.1038/s41467-022-33193-0.
Integrated Single Cell Atlas of Endothelial Cells of the Human LungSchupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single Cell Atlas of Endothelial Cells of the Human Lung Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis.Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6 PMID: 32937511, DOI: 10.1126/sciadv.aba1983.
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial functionYu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo e Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function Nature Medicine 2017, 24: 39-49. PMID: 29200204, PMCID: PMC5760280, DOI: 10.1038/nm.4447.
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosisAhangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
Integrative genetic and genomic networks identify microRNA associated with COPD and ILDPavel A, Garrison C, Luo L, Liu G, Taub D, Xiao J, Juan-Guardela B, Tedrow J, Alekseyev Y, Yang I, Geraci M, Sciurba F, Schwartz D, Kaminski N, Beane J, Spira A, Lenburg M, Campbell J. Integrative genetic and genomic networks identify microRNA associated with COPD and ILD Scientific Reports 2023, 13: 13076. PMID: 37567908, PMCID: PMC10421936, DOI: 10.1038/s41598-023-39751-w.
An integrated cell atlas of the lung in health and diseaseSikkema L, Ramírez-Suástegui C, Strobl D, Gillett T, Zappia L, Madissoon E, Markov N, Zaragosi L, Ji Y, Ansari M, Arguel M, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung M, Collin A, Gay A, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos T, Kole T, Leroy S, Mayr C, Oliver A, von Papen M, Peter L, Taylor C, Walzthoeni T, Xu C, Bui L, De Donno C, Dony L, Faiz A, Guo M, Gutierrez A, Heumos L, Huang N, Ibarra I, Jackson N, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini K, Wilbrey-Clark A, Worlock K, Yoshida M, van den Berge M, Bossé Y, Desai T, Eickelberg O, Kaminski N, Krasnow M, Lafyatis R, Nikolic M, Powell J, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold M, Sheppard D, Shepherd D, Sin D, Timens W, Tsankov A, Whitsett J, Xu Y, Banovich N, Barbry P, Duong T, Falk C, Meyer K, Kropski J, Pe’er D, Schiller H, Tata P, Schultze J, Teichmann S, Misharin A, Nawijn M, Luecken M, Theis F. An integrated cell atlas of the lung in health and disease Nature Medicine 2023, 29: 1563-1577. PMID: 37291214, PMCID: PMC10287567, DOI: 10.1038/s41591-023-02327-2.
Medical Societies Must Choose Professional Meeting Locations Responsibly in a Post-Roe WorldLee A, Maley J, Hibbert K, Akgün K, Hauschildt K, Law A, Kaminski N, Hayes M, Gesthalter Y, Bosslet G, Santhosh L, Witkin A, Hills-Dunlap K, Çoruh B, Gershengorn H, Hardin C. Medical Societies Must Choose Professional Meeting Locations Responsibly in a Post-Roe World Annals Of The American Thoracic Society 2023, 20: 781-784. PMID: 36812378, PMCID: PMC10257035, DOI: 10.1513/annalsats.202211-928ip.
Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb M. Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1498-1514. PMID: 36917778, DOI: 10.1164/rccm.202109-2174oc.
PCSK6 and Survival in Idiopathic Pulmonary FibrosisOldham J, Allen R, Lorenzo-Salazar J, Molyneaux P, Ma S, Joseph C, Kim J, Guillen-Guio B, Hernández-Beeftink T, Kropski J, Huang Y, Lee C, Adegunsoye A, Pugashetti J, Linderholm A, Vo V, Strek M, Jou J, Muñoz-Barrera A, Rubio-Rodriguez L, Hubbard R, Hirani N, Whyte M, Hart S, Nicholson A, Lancaster L, Parfrey H, Rassl D, Wallace W, Valenzi E, Zhang Y, Mychaleckyj J, Stockwell A, Kaminski N, Wolters P, Molina-Molina M, Banovich N, Fahy W, Martinez F, Hall I, Tobin M, Maher T, Blackwell T, Yaspan B, Jenkins R, Flores C, Wain L, Noth I. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1515-1524. PMID: 36780644, PMCID: PMC10263132, DOI: 10.1164/rccm.202205-0845oc.
A Picture Worth a Thousand Words, Created with One Sentence: Using Artificial Intelligence–created Art to Enhance Medical EducationHuston J, Kaminski N. A Picture Worth a Thousand Words, Created with One Sentence: Using Artificial Intelligence–created Art to Enhance Medical Education ATS Scholar 2023 DOI: 10.34197/ats-scholar.2022-0141ps.
Spatial Transcriptomic Analysis Allow the Identification of Abnormal Airway Niches in the Fibrotic LungJustet A, Adams T, Balayev A, Baernthaler T, Poli F, Cala Garcia J, Mcdonough J, Flint J, Schupp J, Zhao A, Yunqing L, Ningshan L, Raredon M, Lepe A, Wang A, Abu Hussein N, Yan X, Rosas I, Kaminski N. Spatial Transcriptomic Analysis Allow the Identification of Abnormal Airway Niches in the Fibrotic Lung 2023, a1033-a1033. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1033.
Online Cell Atlases Improve Interrogation of Lung Transcriptomic DataFlint J, Sharma P, Cosme Jr. C, Neumark N, Adams T, Kim H, Lepe A, Abu Hussein N, Schupp J, Mcdonough J, Sauler M, Yan X, Kaminski N. Online Cell Atlases Improve Interrogation of Lung Transcriptomic Data 2023, a2223-a2223. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2223.
The Pulmonary Fibrosis Drug ConnectomeFlint J, Sharma P, Adams T, Lepe A, Kim H, Abu Hussein N, Schupp J, Cosme Jr. C, Mcdonough J, Sauler M, Yan X, Kaminski N. The Pulmonary Fibrosis Drug Connectome 2023, a2234-a2234. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2234.
Aberrant Basaloid Cells and Closely Connected Intermediate State Cells Are Involved in the Injury Repair Process of the Fibrotic Lungs in the Aftermath of Severe COVID-19Balayev A, Adams T, Justet A, Schupp J, Mcdonough J, Kaminski N. Aberrant Basaloid Cells and Closely Connected Intermediate State Cells Are Involved in the Injury Repair Process of the Fibrotic Lungs in the Aftermath of Severe COVID-19 2023, a5667-a5667. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5667.
G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal CellsKhoury J, Ahangari F, Barnthaler T, McDonough J, Justet A, Adams T, Schupp J, Alysandratos K, Beermann M, Kotton D, Gomez J, Kaminski N. G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal Cells 2023, a6762-a6762. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6762.
Identification of Molecular Profiles Predictive of Outcome by RNA-Sequencing of Formalin-Fixed, Paraffin-Embedded (FFPE) Lung Tissue From Patients With Idiopathic Pulmonary FibrosisKarampitsakos T, Juan-Guardela B, Vukmirovic M, Perrot C, Zhang Y, Gibson K, Vamvakaris I, Tzouvelekis A, Yan X, Kaminski N, Herazo-Maya J. Identification of Molecular Profiles Predictive of Outcome by RNA-Sequencing of Formalin-Fixed, Paraffin-Embedded (FFPE) Lung Tissue From Patients With Idiopathic Pulmonary Fibrosis 2023, a1505-a1505. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1505.
The Therapeutic Gap in Idiopathic Pulmonary Fibrosis: Insights From Single Cell Transcriptional ProfilingMckenna N, Ochsner S, Moss B, Cala Garcia J, Cardenas Castillo R, Poli F, Poli De Frias S, Tsoyi K, Polverino F, Koenigshoff M, Kaminski N, Coarfa C, Rosas I. The Therapeutic Gap in Idiopathic Pulmonary Fibrosis: Insights From Single Cell Transcriptional Profiling 2023, a2235-a2235. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2235.
Cellular Ageing and Senescence Transcriptional Modules in the Aged Human LungDe Man R, Mcdonough J, Adams T, Yan X, Kaminski N. Cellular Ageing and Senescence Transcriptional Modules in the Aged Human Lung 2023, a2663-a2663. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2663.
The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During AgingYuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
Single Nuclear RNAseq of Differentially Affected IPF Lung Uncovers Potential Cellular Origins of Aberrant Basaloid CellsAdams T, Schupp J, Balayev A, Justet A, Sharma P, DeIuliis G, Yan X, Wuyts W, Vanaudenaerde B, Kaminski N. Single Nuclear RNAseq of Differentially Affected IPF Lung Uncovers Potential Cellular Origins of Aberrant Basaloid Cells 2023, a2802-a2802. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2802.
Common and Distinct Bronchoalveolar Lavage and Lung Immune Signatures in Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary FibrosisZhao A, Yan X, Sharma P, Deluliis G, Buendia-Roldan I, Pardo A, Selman M, Kaminski N. Common and Distinct Bronchoalveolar Lavage and Lung Immune Signatures in Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis 2023, a3948-a3948. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3948.
Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
High-dimensional Analysis of Cell-cell Signaling in Pulmonary Biology and Disease Using NichesRaredon M, Yang J, Kothapalli N, Greaney A, Justet A, Adams T, Zhao A, Kim H, Manning E, Medzhitov R, Niklason L, Kaminski N, Kluger Y. High-dimensional Analysis of Cell-cell Signaling in Pulmonary Biology and Disease Using Niches 2023, a4697-a4697. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4697.
Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
Building Epithelial Barrier in Whole-lung Tissue EngineeringGreaney A, Raredon M, Adams T, Langer R, Kaminski N, Niklason L. Building Epithelial Barrier in Whole-lung Tissue Engineering 2023, a6159-a6159. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6159.
MAVS Dependent Immune Responses in Cigarette Smoke Exposure and Influenza Viral InfectionGupta G, Cai C, Kim J, Kim S, Shin H, Kaminski N, Sharma L, Dela Cruz C, Kang M. MAVS Dependent Immune Responses in Cigarette Smoke Exposure and Influenza Viral Infection 2023, a6747-a6747. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6747.
Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in AsthmaChupp G, Liu Q, Adams T, Schupp J, Wilson G, Grant N, Gomez J, Cohn L, Kaminski N, Akuthota P, Weiss S, Glass K, Bleecker E, Meyers D, Tantisira K, Yan X. Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma 2023, a5689-a5689. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5689.
Morphometrics and Mucosal Immune Features in Lungs With End-stage Chronic Obstructive Pulmonary DiseaseDe Fays C, Beeckmans H, Kerckhof P, Geudens V, Vermaut A, Gyselinck I, Goos T, Vermant M, Kaes J, Van Slambrouck J, Mohamady Y, Willems L, Aversa L, Maes K, Aelbrecht C, Everaerts S, Mcdonough J, De Sadeleer L, Gohy S, Ambroise J, Wuyts W, Janssens W, Ceulemans L, Van Raemdonck D, Vos R, Hackett T, Hogg J, Kaminski N, Pilette C, Gayan-Ramirez G, Vanaudenaerde B. Morphometrics and Mucosal Immune Features in Lungs With End-stage Chronic Obstructive Pulmonary Disease 2023, a6145-a6145. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6145.
Rational engineering of lung alveolar epitheliumLeiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.
Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial functionVamesu B, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J. Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function JCI Insight 2023, 8: e160697. PMID: 36917181, PMCID: PMC10243814, DOI: 10.1172/jci.insight.160697.
Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypesLi X, Li H, Christenson S, Castro M, Denlinger L, Erzurum S, Fahy J, Gaston B, Israel E, Jarjour N, Levy B, Mauger D, Moore W, Zein J, Kaminski N, Wenzel S, Woodruff P, Bleecker E, Meyers D, Program F. Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes Journal Of Asthma 2023, ahead-of-print: 1-12. PMID: 36946148, DOI: 10.1080/02770903.2023.2193631.
Emergence of division of labor in tissues through cell interactions and spatial cuesAdler M, Moriel N, Goeva A, Avraham-Davidi I, Mages S, Adams T, Kaminski N, Macosko E, Regev A, Medzhitov R, Nitzan M. Emergence of division of labor in tissues through cell interactions and spatial cues Cell Reports 2023, 42: 112412. PMID: 37086403, PMCID: PMC10242439, DOI: 10.1016/j.celrep.2023.112412.
Transbronchial Lung Cryobiopsy for the Diagnosis of Interstitial Lung DiseaseLow S, Kaminski N, Maldonado F. Transbronchial Lung Cryobiopsy for the Diagnosis of Interstitial Lung Disease Journal Of Bronchology & Interventional Pulmonology 2023, 30: 93-95. PMID: 37005378, DOI: 10.1097/lbr.0000000000000882.
Single-Cell Rna Sequencing of the Mouse Isograft and Allograft Lung after Orthotopic Lung TransplantationHooft C, Kaes J, Heigl T, Beeckmans H, Kerckhof P, Vanstapel A, Jin X, Slambrouck J, Vandervelde C, Van Raemdonck D, Kaminski N, McDonough J, Ceulemans L, Vos R, Vanaudenaerde B. Single-Cell Rna Sequencing of the Mouse Isograft and Allograft Lung after Orthotopic Lung Transplantation The Journal Of Heart And Lung Transplantation 2023, 42: s539. DOI: 10.1016/j.healun.2023.02.1473.
SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung FibroblastsKarampitsakos T, Galaris A, Barbayianni I, DeIuliis G, Ahangari F, Sampsonas F, Sotiropoulou V, Aidinis V, Bennett A, Herazo-Maya J, Xylourgidis N, Bakakos P, Bouros D, Kaminski N, Tzouvelekis A. SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts Diagnostics 2023, 13: 1166. PMID: 36980473, PMCID: PMC10047203, DOI: 10.3390/diagnostics13061166.
Ex vivo Testung der antifibrotischen Wirksamkeit von Medikamenten auf die Idiopathische Lungenfibrose mittels Langzeitkultur von humanen Lungengewebs-Präzisionsschnitte (PCLS)Artysh N, Jäger B, Terwolbeck O, Sewald K, Kaminski N, Zeug A, Prasse A. Ex vivo Testung der antifibrotischen Wirksamkeit von Medikamenten auf die Idiopathische Lungenfibrose mittels Langzeitkultur von humanen Lungengewebs-Präzisionsschnitte (PCLS) Pneumologie 2023, 77: s111-s111. DOI: 10.1055/s-0043-1761142.
A novel Bayesian framework for harmonizing information across tissues and studies to increase cell type deconvolution accuracy.Deng W, Li B, Wang J, Jiang W, Yan X, Li N, Vukmirovic M, Kaminski N, Wang J, Zhao H. A novel Bayesian framework for harmonizing information across tissues and studies to increase cell type deconvolution accuracy. Briefings In Bioinformatics 2023, 24 PMID: 36631398, PMCID: PMC9851324, DOI: 10.1093/bib/bbac616.
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infectionAsashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein S, Montgomery R, Iwasaki A, Dela Cruz C, Kaminski N, Shaw A, Hafler D, Sumida T. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection Cell Reports 2023, 42: 111895. PMID: 36596303, PMCID: PMC9806868, DOI: 10.1016/j.celrep.2022.111895.
Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHESRaredon M, Yang J, Kothapalli N, Lewis W, Kaminski N, Niklason L, Kluger Y. Comprehensive visualization of cell–cell interactions in single-cell and spatial transcriptomics with NICHES Bioinformatics 2022, 39: btac775. PMID: 36458905, PMCID: PMC9825783, DOI: 10.1093/bioinformatics/btac775.
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2022 PMID: 36450109, DOI: 10.1165/rcmb.2022-0219oc.
Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea.Cortese R, Adams T, Cataldo K, Hummel J, Kaminski N, Kheirandish-Gozal L, Gozal D. Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea. European Respiratory Journal 2022, 61: 2201465. PMID: 36356973, DOI: 10.1183/13993003.01465-2022.
Lung Cell Atlases in Health and DiseaseAdams T, Marlier A, Kaminski N. Lung Cell Atlases in Health and Disease Annual Review Of Physiology 2022, 85: 47-69. PMID: 36351366, DOI: 10.1146/annurev-physiol-032922-082826.
Microenvironmental sensing by fibroblasts controls macrophage population sizeZhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Microenvironmental sensing by fibroblasts controls macrophage population size Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2205360119. PMID: 35930670, PMCID: PMC9371703, DOI: 10.1073/pnas.2205360119.
From COVID to fibrosis: lessons from single-cell analyses of the human lungJustet A, Zhao AY, Kaminski N. From COVID to fibrosis: lessons from single-cell analyses of the human lung Human Genomics 2022, 16: 20. PMID: 35698166, PMCID: PMC9189802, DOI: 10.1186/s40246-022-00393-0.
Soluble Signals to Improve Endothelial Integrity in the LungYuan Y, Raredon M, Yuan Q, Obata T, Qian H, Wu D, Kaminski N, Niklason L. Soluble Signals to Improve Endothelial Integrity in the Lung 2022, a5749-a5749. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5749.
Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and FerroptosisNouws J, Mcdonough J, Adams T, Werder R, Schupp J, Robertson M, Coarfa C, Poli De Frias S, Wilson A, Timshel P, Kaminski N, Rosas I, Sauler M. Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and Ferroptosis 2022, a1040-a1040. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1040.
New Insights on Idiopathic Pulmonary Fibrosis Revealed by Proteomics and Lipidomics Analysis of Human Tissue CoresClair G, Kyle J, Melchior J, Olson H, Paurus V, Bloodsworth K, Schupp J, Mcdonough J, Wuyts W, Vanaudenaerde B, Kaminski N. New Insights on Idiopathic Pulmonary Fibrosis Revealed by Proteomics and Lipidomics Analysis of Human Tissue Cores 2022, a1972-a1972. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1972.
Leveraging Cell-Specific Disease Signatures to Predict New Drug Therapies for Idiopathic Pulmonary FibrosisAdams T, Song Q, Justet A, Mcdonough J, DeIuliis G, Yan X, Bar-Joseph Z, Kaminski N. Leveraging Cell-Specific Disease Signatures to Predict New Drug Therapies for Idiopathic Pulmonary Fibrosis 2022, a2318-a2318. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2318.
GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF LungKhoury J, Ahangari F, Barnthaler T, McDonough J, Kothapalli N, Adams T, Schupp J, DeIuliis G, Gomez J, Kaminski N. GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF Lung 2022, a2325-a2325. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2325.
Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged LungMcdonough J, Cosme Jr. C, Rupert C, Schupp J, Ahangari F, DeIuliis G, Yan X, Hagood J, Vanaudenaerde B, Niklason L, Hansen K, Kaminski N. Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged Lung 2022, a3903-a3903. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3903.
Aberrant Mesenchymal Signaling in the COPD LungBrewster R, Neeharika N, Mcdonough J, Adams T, Schupp J, Niklason L, Raredon M, Kaminski N, Rosas I, Sauler M. Aberrant Mesenchymal Signaling in the COPD Lung 2022, a4655-a4655. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4655.
Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease ProgressionSchupp J, Clair G, Adams T, Mcdonough J, Flint J, Kothapalli N, De Sadeleer L, Justet A, Melchior J, Paurus V, Olson H, Deluliis G, Ahangari F, Bar-Joseph Z, Yan X, Ding J, Wuyts W, Vanaudenaerde B, Kaminski N. Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease Progression 2022, a4975-a4975. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4975.
Interactive Web-Based Lung Cell Atlases Lower Barriers to Transcriptomic Data Sharing, Mining and DisseminationCosme Jr. C, Flint J, Neumark N, Kothapalli N, Balayev A, Adams T, Schupp J, Mcdonough J, Yan X, Sauler M, Kaminski N. Interactive Web-Based Lung Cell Atlases Lower Barriers to Transcriptomic Data Sharing, Mining and Dissemination 2022, a4978-a4978. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4978.
A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis ProgressionDing J, Zheng Y, Schupp J, Adams T, Ahangari F, Yan X, Hasen P, Bar-Joseph Z, De Sadeleer L, Mcdonough J, Vanaudenaerde B, Wuyts W, Kaminski N. A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis Progression 2022, a4986-a4986. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4986.
Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic LungJustet A, Adams T, Balayev A, Bärnthaler T, Cosme Jr C, Mcdonough J, Flint J, Schupp J, Zhao A, Deluliis J, Ahangari F, Yan X, Kaminski N. Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic Lung 2022, a4991-a4991. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4991.
Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung InjuryChioccioli M, Mcdonough J, Yang T, Gonzalez D, Rivera-Molina F, Kaminski N, Sauler M, DeIuliis G. Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung Injury 2022, a5477-a5477. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5477.
Cigarette Smoke Exposure or Nigericin/LPS Stimulation Induces MAVS Aggregation, Which Is Further Augmented in NLRX1 DeficiencyGupta G, Kim S, Shin H, Wei L, Rosas I, Kaminski N, Sharma L, Dela Cruz C, Kang M. Cigarette Smoke Exposure or Nigericin/LPS Stimulation Induces MAVS Aggregation, Which Is Further Augmented in NLRX1 Deficiency 2022, a1214-a1214. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1214.
CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell AgingLiu G, Cui H, Xie N, Banerjee S, Liu R, Antony V, Sanders Y, Thannickal V, Kaminski N. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging 2022, a2310-a2310. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2310.
Integrating Gene Expression with Genome-Wide Association Summary Statistics to Identify Genes Associated with Idiopathic Pulmonary Fibrosis SurvivalHu X, Kim J, Ma S, Huang Y, Oldham J, Allen R, Molyneaux P, Joseph C, Guillen Guio B, Hernández Beeftink T, Kropski J, Lee C, Adegunsoye A, Pugashetti J, Linderholm A, Strek M, Hubbard R, Hart S, Nicholson A, Lancaster L, Lorenzo-Salazar J, Vo V, Hirani N, Whyte M, Parfrey H, Rassl D, Wallace W, Valenzi E, Zhang Y, Stockwell A, Kaminski N, Wolters P, Molina-Molina M, Martinez F, Hall I, Tobin M, Maher T, Blackwell T, Yaspan B, Jenkins R, Wain L, Flores C, Noth I, Manichaikul A. Integrating Gene Expression with Genome-Wide Association Summary Statistics to Identify Genes Associated with Idiopathic Pulmonary Fibrosis Survival 2022, a2326-a2326. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2326.
Single-Cell RNAseq Reveals Cell Composition and Gene Expression Patterns in the Peripheral Blood of Pediatric Obstructive Sleep ApneaCortese R, Adams T, Hohensee K, Kaminski N, Gozal L, Gozal D. Single-Cell RNAseq Reveals Cell Composition and Gene Expression Patterns in the Peripheral Blood of Pediatric Obstructive Sleep Apnea 2022, a2565-a2565. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2565.
Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells Reveals That T Cell Composition, Gene Expression, and Clonotype Significantly Distinguish Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary FibrosisZhao A, Unterman A, Adams T, Yan X, Justet A, Deluliis G, Herzog E, Prasse A, Buendía-Roldán I, Pardo A, Selman M, Kaminski N. Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells Reveals That T Cell Composition, Gene Expression, and Clonotype Significantly Distinguish Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis 2022, a3522-a3522. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3522.
Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta AgonistBaernthaler T, Ding S, Chioccioli M, Poli F, Justet A, Rose K, Cosme Jr. C, Adams T, Ahangari F, Rosas I, Kaminski N. Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta Agonist 2022, a3722-a3722. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3722.
Toll-Like-Receptor 5 Protects Against Pulmonary Fibrosis by Reducing Lung DysbiosisSakamachi Y, Solis A, Johnson C, Hussain S, O'Dwyer D, Mehta S, Trempus C, Thomas S, Karmaus P, Schwartz D, Kaminski N, Zhang Y, Yang I, Molyneaux P, Kass D, Gibson K, Garantziotis S. Toll-Like-Receptor 5 Protects Against Pulmonary Fibrosis by Reducing Lung Dysbiosis 2022, a4990-a4990. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4990.
Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Singh I, Tellides G, Gill T, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary Artery 2022, a5205-a5205. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5205.
Differential RNAseq Analysis of an Ex-Vivo Human Fibrotic Tissue Slice Model Reveals Dysregulated Genes of Cellular Senescence and YAP/TAZ Signaling in FibrosisPineda R, Mitash N, Kohler K, Melo Narvaez M, Sembrat J, Fangping M, Lehmann M, Kaminski N, Koenigshoff M. Differential RNAseq Analysis of an Ex-Vivo Human Fibrotic Tissue Slice Model Reveals Dysregulated Genes of Cellular Senescence and YAP/TAZ Signaling in Fibrosis 2022, a5229-a5229. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5229.
Changes in Immune Cell Populations in the Peripheral Blood of Individuals with Interstitial Lung AbnormalitiesZhao A, Unterman A, Adams T, Justet A, Yan X, Deluliis G, Herzog E, Prasse A, Buendia-Roldan I, Pardo A, Selman M, Kaminski N. Changes in Immune Cell Populations in the Peripheral Blood of Individuals with Interstitial Lung Abnormalities 2022, a5273-a5273. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5273.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason L, Ko A, Montgomery R, Farhadian S, Iwasaki A, Shaw A, van Dijk D, Zhao H, Kleinstein S, Hafler D, Kaminski N, Dela Cruz C. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 Nature Communications 2022, 13: 440. PMID: 35064122, PMCID: PMC8782894, DOI: 10.1038/s41467-021-27716-4.
Metagenomic sequencing of the bronchoalveolar lavage extracellular virome and cellular transcriptome of sarcoidosis patients does not detect rubella virusKeeler E, Vukmirovic M, Yan X, Gulino K, Ghedin E, Kaminski N, Sullivan K, Bushman F, Collman R, Rosenbach M. Metagenomic sequencing of the bronchoalveolar lavage extracellular virome and cellular transcriptome of sarcoidosis patients does not detect rubella virus Sarcoidosis, Vasculitis, And Diffuse Lung Diseases 2022, 39: e2022040. PMID: 36533601, PMCID: PMC9798337, DOI: 10.36141/svdld.v39i4.13407.
S98 Dissecting human pleura at single-cell resolutionObacz J, Adams T, Schupp J, Kaminski N, Aresu G, Coonar A, Peryt A, Rassl D, Rintoul R, Marciniak S. S98 Dissecting human pleura at single-cell resolution 2021, a63.1-a63. DOI: 10.1136/thorax-2021-btsabstracts.104.
S65 Genome-wide association study of survival times after diagnosis of idiopathic pulmonary fibrosisAllen R, Oldham J, Lorenzo-Salazar J, Molyneaux P, Ma S, Stockwell A, Joseph C, Kim J, Guillen-Guio B, Hernandez-Beeftink T, Kropski J, Huang Y, Lee C, Adegunsoye A, Pugashetti J, Linderholm A, Vo V, Strek M, Hubbard R, Hirani N, Whyte M, Hart S, Nicholson A, Parfrey H, Rassl D, Wallace W, Fahy W, Valenzi E, Zhang Y, Kaminski N, Wolters P, Molina-Molina M, Martinez F, Hall I, Tobin, Maher T, Blackwell T, Yaspan B, Jenkins R, Flores C, Wain L, Noth I. S65 Genome-wide association study of survival times after diagnosis of idiopathic pulmonary fibrosis Thorax 2021, 76: a43-a43. DOI: 10.1136/thorax-2021-btsabstracts.71.
T3 Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies sphingosine kinase 1 as a potential therapeutic targetReichmann M, Tezera L, Vallejo A, Vukmirovic M, Xiao R, Jogai S, Wilson S, Marshall, Jones, Leslie A, D’Armiento J, Kaminski N, Polak M, Elkington P. T3 Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies sphingosine kinase 1 as a potential therapeutic target Thorax 2021, 76: a2-a3. DOI: 10.1136/thorax-2021-btsabstracts.3.
S63 Genome-wide sex-by-SNP interaction analysis of susceptibility to idiopathic pulmonary fibrosisLeavy O, Allen R, Oldham J, Guillen-Guio B, Stockwell A, Braybrooke R, Hubbard R, Ma S, Fingerlin T, Kaminski N, Zhang Y, Schwartz D, Yaspan B, Maher T, Molyneaux P, Flores C, Noth I, Jenkins R, Wain L. S63 Genome-wide sex-by-SNP interaction analysis of susceptibility to idiopathic pulmonary fibrosis Thorax 2021, 76: a42-a42. DOI: 10.1136/thorax-2021-btsabstracts.69.
Aberrant endothelial CXCL signaling in COPDKothapalli N, Mcdonough J, Raredon M, Adams T, Schupp J, Niklason L, Kaminski N, Rosas I, Sauler M. Aberrant endothelial CXCL signaling in COPD 2021, pa3623. DOI: 10.1183/13993003.congress-2021.pa3623.
Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPDMcDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme Jr. C, Poli De Frias S, Ayaub E, Chu S, Jensen K, Gomez J, Britto-Leon C, Raredon M, Niklason L, Timshel P, Kaminski N, Rosas I, Sauler M. Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD 2021, a4281-a4281. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4281.
Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell StateSchupp J, Adams T, Ahangari F, McDonough J, DeIuliis G, Poli S, Rosas I, Yan X, Kaminski N. Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell State 2021, a4350-a4350. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4350.
Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of LymphocytesAdams T, Schupp J, Mcdonough J, Chioccioli M, Rose K, DeIuliis G, Yan X, Kaminski N. Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of Lymphocytes 2021, a4351-a4351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4351.
Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived CellsCosme Jr. C, Adams T, Schupp J, Mcdonough J, Ahangari F, DeIuliis G, Omote N, Dixit V, Kaminski N. Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived Cells 2021, a4402-a4402. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4402.
Macrophage Specific Regulatory Role of miR-33 in Pulmonary FibrosisAhangari F, Chioccioli M, Malik S, Baernthaler T, Price N, Ding S, Rose K, Mcdonough J, Omote N, Schupp J, Adams T, Sharma L, DeIuliis G, Dela Cruz C, Prasse A, Bahal R, Fernandez-Hernando C, Kaminski N. Macrophage Specific Regulatory Role of miR-33 in Pulmonary Fibrosis 2021, a4452-a4452. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4452.
IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In VivoMinasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog E, Dela Cruz C, Ryu C. IL-15 Is Independent of Pulmonary Sarcoid Granuloma Formation In Vivo 2021, a4263-a4263. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4263.
Engineered Lung Reveals a Fibroblast-Endothelial Niche Supporting Alveolar Epithelial Type 2 Cell Growth and PhenotypeLeiby K, Yuan Y, Raredon M, Adams T, Kaminski N, Herzog E, Niklason L. Engineered Lung Reveals a Fibroblast-Endothelial Niche Supporting Alveolar Epithelial Type 2 Cell Growth and Phenotype 2021, a1141-a1141. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1141.
Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from HypoxiaManning E, Ramachandra A, Schupp J, Cavinato C, Singh I, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from Hypoxia 2021, a3625-a3625. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3625.
RNA-Seq Reveals Antifibrotic Effects of Sobetirome in Human Lung FibroblastsRose K, Adams T, Ahangari F, Ding S, DeIuliis G, Kaminski N. RNA-Seq Reveals Antifibrotic Effects of Sobetirome in Human Lung Fibroblasts 2021, a4247-a4247. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4247.
Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression ProfilesZhao A, Unterman A, Schupp J, Adams T, Sumida T, Ryu C, DeIuliis G, Yan X, Hafler D, Dela Cruz C, Herzog E, Kaminski N. Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles 2021, a4361-a4361. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4361.
Targeting the IPF-Expanded Macrophages: Identification and Drug Discovery via scRNAseq and CyTOFPoli De Frias S, Ayaub E, Adams T, Schupp J, Ng J, Quesada L, Martinez J, Planchart M, Robertson M, Chu S, Coarfa C, El-Chemaly S, Perrella M, Washko G, Raby B, Kaminski N, Rosas I. Targeting the IPF-Expanded Macrophages: Identification and Drug Discovery via scRNAseq and CyTOF 2021, a4435-a4435. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4435.
The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary FibrosisBaernthaler T, Ahangari F, Chioccioli M, Adams T, Rose K, Ding S, Kaminski N. The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary Fibrosis 2021, a4449-a4449. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4449.
Prediction of Survival after Chronic Lung Allograft Dysfunction in Lung Transplant Recipients by Blood Profiling Using a Predefined 52 Gene SignatureLuijk B, Krebber M, Li Q, Kardol-Hoefnagel T, Budding K, van Kessel D, Grutters J, Otten H, Kaminski N, Maya J. Prediction of Survival after Chronic Lung Allograft Dysfunction in Lung Transplant Recipients by Blood Profiling Using a Predefined 52 Gene Signature The Journal Of Heart And Lung Transplantation 2021, 40: s155-s156. DOI: 10.1016/j.healun.2021.01.470.
Abstract 14125: An in vitro Pulmonary Vascular Platform From Endothelialized Whole Lung ScaffoldsYuan Y, Leiby K, Greaney A, Raredon M, Qian H, Baevova P, Admas T, Engler A, Kural M, Schupp J, Hong Y, Kaminski N, Niklason L. Abstract 14125: An in vitro Pulmonary Vascular Platform From Endothelialized Whole Lung Scaffolds Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.14125.
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergeticsBlumental-Perry A, Jobava R, Bederman I, Degar A, Kenche H, Guan B, Pandit K, Perry N, Molyneaux N, Wu J, Prendergas E, Ye Z, Zhang J, Nelson C, Ahangari F, Krokowski D, Guttentag S, Linden P, Townsend D, Miron A, Kang M, Kaminski N, Perry Y, Hatzoglou M. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics Communications Biology 2020, 3: 626. PMID: 33127975, PMCID: PMC7603330, DOI: 10.1038/s42003-020-01322-4.
FK506-binding protein 11, a novel plasma cell specific antibody folding catalyst, is increased in idiopathic pulmonary fibrosisPreisendörfer S, Ishikawa Y, Knüppel L, Fernandez I, Binzenhöfer L, Juan-Guardela B, Hennen E, Ruppert C, Guenther A, Kneidinger N, Frankenberger M, Hatz R, Behr J, Schepers A, Hilgendorff A, Kaminski N, Bächinger H, Eickelberg O, Staab-Weijnitz C. FK506-binding protein 11, a novel plasma cell specific antibody folding catalyst, is increased in idiopathic pulmonary fibrosis 2020, 2293. DOI: 10.1183/13993003.congress-2020.2293.
During the COVID-19 Pandemic, Lung Specialists of the World Implore You: Inhale Only Clean AirSanthosh L, Oh A, Alismail A, Breiburg A, Kaminski N, Carlos G, Jamil S. During the COVID-19 Pandemic, Lung Specialists of the World Implore You: Inhale Only Clean Air American Journal Of Respiratory And Critical Care Medicine 2020 DOI: 10.1164/rccm.2020c13.
Social Media Engagement During Pulmonary Disease National Health Observance Awareness MonthsPeabody Lever J, Carroll C, Kaminski N, Rowe S. Social Media Engagement During Pulmonary Disease National Health Observance Awareness Months 2020, a6614-a6614. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6614.
Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory AberrationsCosme Jr. C, McDonough J, Adams T, Schupp J, Omote N, Ahangari F, DeIuliis G, Sakamoto K, Kaminski N. Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory Aberrations 2020, a4389-a4389. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4389.
Low Surfactant Type II Alveolar Epithelial Cells Are an Enriched Cell Population in the Aged LungMcDonough J, Adams T, Schupp J, DeIuliis G, Yan X, Cosme jr C, Kaminski N. Low Surfactant Type II Alveolar Epithelial Cells Are an Enriched Cell Population in the Aged Lung 2020, a4390-a4390. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4390.
Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPFAdams T, Schupp J, McDonough J, Ahangari F, DeIuliis G, Yan X, Rosas I, Kaminski N. Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPF 2020, a2248-a2248. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2248.
Gene Expression Patterns Distinctly Characterize Differentially Affected Regions in Human Fibrotic Hypersensitivity Pneumonitis LungsDe Sadeleer L, McDonough J, Schupp J, Yan X, Vanaudenaerde B, Verleden S, Kaminski N, Wuyts W. Gene Expression Patterns Distinctly Characterize Differentially Affected Regions in Human Fibrotic Hypersensitivity Pneumonitis Lungs 2020, a2262-a2262. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2262.
Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene SignatureUnterman A, Neumark N, Zhao A, Schupp J, Ryu C, Antin-Ozerkis D, Winkler J, Herazo-Maya J, Herzog E, Kaminski N. Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature 2020, a6211-a6211. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6211.
Single Cell RNA Sequencing Reveals Altered T-Cell Repertoire and Gene Expression in the Peripheral Blood and Lungs of Patients with Idiopathic Pulmonary FibrosisUnterman A, Neumark N, Zhao A, Schupp J, Adams T, Antin-Ozerkis D, Winkler J, Banovich N, Kropski J, Herzog E, Kaminski N. Single Cell RNA Sequencing Reveals Altered T-Cell Repertoire and Gene Expression in the Peripheral Blood and Lungs of Patients with Idiopathic Pulmonary Fibrosis 2020, a2516-a2516. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2516.
Unbiased RNA-Sequencing Analysis Demonstrates Common and Unique Features of Tuberculosis and Sarcoidosis Lymph Node SamplesReichmann M, Vukmirovic M, Vallejo A, Tezera L, Jones M, Kaminski N, Polak M, Elkington P. Unbiased RNA-Sequencing Analysis Demonstrates Common and Unique Features of Tuberculosis and Sarcoidosis Lymph Node Samples 2020, a1048-a1048. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1048.
Exosomal Protein Signature for Non-Invasive Differential Diagnosis of Idiopathic Pulmonary FibrosisAdduri S, Alzate K, Iliuk A, Cai K, Miller J, Pal A, Poli De Frias S, Vasireddy R, Nicastro D, Kaminski N, Rosas I, Konduru N. Exosomal Protein Signature for Non-Invasive Differential Diagnosis of Idiopathic Pulmonary Fibrosis 2020, a2568-a2568. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2568.
T Cell Immunophenotypes in Sarcoidosis Identified by Cluster Analysis and a Transcriptomic IntegrationLiao S, Li L, Barkes B, Macphail K, Bowler R, Kaminski N, Wisniewski S, Hamzeh N, Maier L. T Cell Immunophenotypes in Sarcoidosis Identified by Cluster Analysis and a Transcriptomic Integration 2020, a3630-a3630. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3630.
Background Contamination Correction in Human Lung Single-Cell RNA Sequencing DataZang W, Schupp J, Kane M, Adams T, Poli De Frias S, Rosas I, Kaminski N, Chu J. Background Contamination Correction in Human Lung Single-Cell RNA Sequencing Data 2020, a4024-a4024. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4024.
Genetic Analyses Identify IL1R2-IL1RL1-IL18R1 in Chr2q Region Associated with Asthma and COPDLi X, Christenson S, Kaminski N, Wenzel S, Woodruff P, Meyers D, Bleecker E, the Subpopulations and Intermediate Outcomes in CO P, the Severe Asthma Research Program (SARP). Genetic Analyses Identify IL1R2-IL1RL1-IL18R1 in Chr2q Region Associated with Asthma and COPD 2020, a4218-a4218. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4218.
Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Hashimoto N, Hasegawa Y, Kaminski N. Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell Differentiation 2020, a5987-a5987. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5987.
Retrograde Signaling by Mitochondria-Encoded Mito-ncR-805 Preserves Mitochondrial Function of Alveolar Epithelial Type 2 Cells During Exposure to Cigarette SmokeBlumental-Perry A, Jobava R, Guan B, Bederman I, Ye Z, Perry N, Molyneaux N, Wu J, Guttentag S, Townsend D, Miron A, Kang M, Shadel G, Kaminski N, Perry Y, Hatzoglou M. Retrograde Signaling by Mitochondria-Encoded Mito-ncR-805 Preserves Mitochondrial Function of Alveolar Epithelial Type 2 Cells During Exposure to Cigarette Smoke 2020, a6384-a6384. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6384.
Saracatinib Is a Potential Novel Therapeutic for Pulmonary FibrosisAhangari F, Becker C, Foster D, Chioccioli M, Nelson M, Beke K, Meador C, Wang X, Corell K, Roybal H, DeIuliis G, Rose K, Schupp J, Li Q, Adams T, Aschner Y, Lilli L, Readhead B, Cousens L, Dudley J, Kaminski N, Downey G. Saracatinib Is a Potential Novel Therapeutic for Pulmonary Fibrosis 2020, a2784-a2784. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2784.
Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung CancerSchupp J, Adams T, Ahangari F, Poli De Frias S, DeIuliis G, Yan X, Rosas I, Homer R, Kaminski N. Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung Cancer 2020, a6142-a6142. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6142.
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across TissuesZiegler C, Allon S, Nyquist S, Mbano I, Miao V, Tzouanas C, Cao Y, Yousif A, Bals J, Hauser B, Feldman J, Muus C, Wadsworth M, Kazer S, Hughes T, Doran B, Gatter G, Vukovic M, Taliaferro F, Mead B, Guo Z, Wang J, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre J, Taylor C, Lin B, Waghray A, Mitsialis V, Dwyer D, Buchheit K, Boyce J, Barrett N, Laidlaw T, Carroll S, Colonna L, Tkachev V, Peterson C, Yu A, Zheng H, Gideon H, Winchell C, Lin P, Bingle C, Snapper S, Kropski J, Theis F, Schiller H, Zaragosi L, Barbry P, Leslie A, Kiem H, Flynn J, Fortune S, Berger B, Finberg R, Kean L, Garber M, Schmidt A, Lingwood D, Shalek A, Ordovas-Montanes J, Network H, Banovich N, Barbry P, Brazma A, Desai T, Duong T, Eickelberg O, Falk C, Farzan M, Glass I, Haniffa M, Horvath P, Hung D, Kaminski N, Krasnow M, Kropski J, Kuhnemund M, Lafyatis R, Lee H, Leroy S, Linnarson S, Lundeberg J, Meyer K, Misharin A, Nawijn M, Nikolic M, Ordovas-Montanes J, Pe’er D, Powell J, Quake S, Rajagopal J, Tata P, Rawlins E, Regev A, Reyfman P, Rojas M, Rosen O, Saeb-Parsy K, Samakovlis C, Schiller H, Schultze J, Seibold M, Shalek A, Shepherd D, Spence J, Spira A, Sun X, Teichmann S, Theis F, Tsankov A, van den Berge M, von Papen M, Whitsett J, Xavier R, Xu Y, Zaragosi L, Zhang K. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues Cell 2020, 181: 1016-1035.e19. PMID: 32413319, PMCID: PMC7252096, DOI: 10.1016/j.cell.2020.04.035.
IntroductionGomez J, Kaminski N, Himes B. Introduction 2020, 3-8. DOI: 10.1007/978-3-030-31507-8_1.
Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep MedicineGomez J, Kaminski N, Himes B. Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine 2020, 417-428. DOI: 10.1007/978-3-030-31507-8_28.
BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of MedicationsWeathington N, O’Brien M, Radder J, Whisenant TC, Bleecker ER, Busse WW, Erzurum SC, Gaston B, Hastie A, Jarjour N, Meyers D, Milosevic J, Moore W, Tedrow J, Trudeau J, Wong H, Wu W, Kaminski N, Wenzel S, Modena B. BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications American Journal Of Respiratory And Critical Care Medicine 2019, 200: 837-856. PMID: 31161938, PMCID: PMC6812436, DOI: 10.1164/rccm.201811-2221oc.
Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in SarcoidosisSchupp J, Adams T, Jäger B, Deluiis G, Ahangari F, Kaminski N, Prasse A. Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in Sarcoidosis 2019, oa5154. DOI: 10.1183/13993003.congress-2019.oa5154.
SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagyTzouvelekis A, Yu G, Ahangari F, Bennett A, Karampitsakos T, Bouros D, Bouros E, Kaminski N. SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy 2019, pa583. DOI: 10.1183/13993003.congress-2019.pa583.
The Transciptome of BAL Cells at Acute Exacerbation of IPF reveals New InsightsCarleo A, Deluca D, Bargagli E, Wuyts W, Kaminski N, Prasse A. The Transciptome of BAL Cells at Acute Exacerbation of IPF reveals New Insights 2019, pa597. DOI: 10.1183/13993003.congress-2019.pa597.
Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosisXylourgidis N, Min K, Ahangari F, Yu G, Herazo-Maya JD, Karampitsakos T, Aidinis V, Binzenhöfer L, Bouros D, Bennett AM, Kaminski N, Tzouvelekis A. Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis American Journal Of Physiology - Lung Cellular And Molecular Physiology 2019, 317: l678-l689. PMID: 31483681, PMCID: PMC6879900, DOI: 10.1152/ajplung.00264.2018.
The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and DiseaseSchiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Braga F, Timens W, Koppelman GH, Budinger GRS, Burgess JK, Waghray A, van den Berge M, Theis F, Regev A, Kaminski N, Rajagopal J, Teichmann S, Misharin A, Nawijn M. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease American Journal Of Respiratory Cell And Molecular Biology 2019, 61: 31-41. PMID: 30995076, PMCID: PMC6604220, DOI: 10.1165/rcmb.2018-0416tr.
Role of Terra on Telomeric and Mitochondrial Functions in IPF PathogenesisYu G, Yang J, Zhao W, Iberra G, Chen X, Guo X, Kaminski N. Role of Terra on Telomeric and Mitochondrial Functions in IPF Pathogenesis 2019, a1045-a1045. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1045.
Pink1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-Induced Lung InjuryZhang Y, Yu G, Kaminski N, Lee P. Pink1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-Induced Lung Injury 2019, a7069-a7069. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7069.
Epigenetic Age Acceleration in Idiopathic Pulmonary FibrosisKurbanov D, Ahangari F, Xylourgidis N, McDonough J, Wuyts W, Vanaudenaerde B, Levine M, Kaminski N. Epigenetic Age Acceleration in Idiopathic Pulmonary Fibrosis 2019, a5265-a5265. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5265.
Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in LungRaredon M, Adams T, Schupp J, Suhail Y, Leiby K, Greaney A, Boffa D, Levchenko A, Kaminski N, Niklason L. Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in Lung 2019, a6073-a6073. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6073.
Changes in Lung Histopathology from Diagnosis to Transplant in IPF PatientsUnterman A, Pertzov B, Kaminski N, Kramer M. Changes in Lung Histopathology from Diagnosis to Transplant in IPF Patients 2019, a1460-a1460. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1460.
Short-Term Longitudinal Gene Expression Changes Predict Forced Vital Capacity Decline in Idiopathic Pulmonary FibrosisHuang Y, Oldham J, Ma S, Hou P, Strek M, Molyneaux P, Maher T, Kaminski N, Herazo-Maya J, Martinez F, Noth I. Short-Term Longitudinal Gene Expression Changes Predict Forced Vital Capacity Decline in Idiopathic Pulmonary Fibrosis 2019, a2426-a2426. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2426.
Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene ExpressionPoli De Frias S, Adams T, Schupp J, Chu S, Neumark N, Ahangari F, Waskho G, Raby B, Kaminski N, Rosas I. Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene Expression 2019, a2550-a2550. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2550.
Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic InjuryLi Q, Omote N, Adams T, Chioccioli M, Shakya A, DeIuliis G, Herzog E, Tantin D, Herazo-Maya J, Kaminski N. Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic Injury 2019, a2827-a2827. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2827.
Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell PopulationSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, Omote N, Chioccioli M, Xylourgidis N, DeIuliis G, Chu S, Yan X, Rosas I, Kaminski N. Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population 2019, a4017-a4017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4017.
Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF LungAdams T, Schupp J, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Raredon M, Yan X, Rosas I, Kaminski N. Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF Lung 2019, a4018-a4018. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4018.
Evaluating the Role of Support Group Participation on Palliative Care Referral and Mortality in Idiopathic Pulmonary FibrosisZou R, Nouraie S, Rosenzweig M, Chen X, Kaminski N, Gibson K, Kass D, Lindell K. Evaluating the Role of Support Group Participation on Palliative Care Referral and Mortality in Idiopathic Pulmonary Fibrosis 2019, a4093-a4093. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4093.
Viral Pneumonia Is an Independent Risk Factor for Pulmonary Fibrosis: Results of Large-Scale Longitudinal Population-Level DataShojaee A, Kaminski N, Siner J, Aryan Y, Yan X, Dela Cruz C. Viral Pneumonia Is an Independent Risk Factor for Pulmonary Fibrosis: Results of Large-Scale Longitudinal Population-Level Data 2019, a4213-a4213. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4213.
Conserved Role of High CO 2 in Regulating Gene Expression of Wnt Signaling PathwayShigemura M, Lecuona E, Angulo M, Edwards M, Welch L, Casalino-Matsuda M, Sporn P, Nader G, Vadasz I, Gruenbaum Y, Beitel G, Kaminski N, Berdnikovs S, Sznajder J. Conserved Role of High CO 2 in Regulating Gene Expression of Wnt Signaling Pathway 2019, a4437-a4437. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4437.
Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF PatientsSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Yan X, Kaminski N, Prasse A, Rosas I. Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF Patients 2019, a5247-a5247. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5247.
Bronchoalveolar Cell Transcriptome of Acute Exacerbation in Idiopathic Pulmonary FibrosisPrasse A, Jäger B, Schupp J, Kaminski N, Carleo A. Bronchoalveolar Cell Transcriptome of Acute Exacerbation in Idiopathic Pulmonary Fibrosis 2019, a5259-a5259. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5259.
Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPFVukmirovic M, Brereton C, Yan X, Xylourgidis N, Deluliis G, Woolard T, Hu B, Mihaljinec A, Homer R, Maya J, Ahangari F, Fabre A, Smart D, Conforti F, Marshall B, Alzetani A, Davies D, Richeldi L, Kaminski N, Jones M. Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPF 2019, a5262-a5262. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5262.
Loss of lncRNA FENDRR Induces Senescence in Adult Mouse LungsXylourgidis N, Sakamoto K, Schupp J, Adams T, DeIuliis G, Omote N, Hashimoto N, Hasegawa Y, Kaminski N. Loss of lncRNA FENDRR Induces Senescence in Adult Mouse Lungs 2019, a5274-a5274. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5274.
TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Xylourgidis N, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation 2019, a5406-a5406. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5406.
Deletion of Pou2af1 in Type II Alveolar Epithelial Cells Augments Bleomycin-Induced Pulmonary FibrosisLi Q, Omote N, Chen Z, DeIuliis G, Zhu Z, Herzog E, Shakya A, Tantin D, Herazo-Maya J, Kaminski N. Deletion of Pou2af1 in Type II Alveolar Epithelial Cells Augments Bleomycin-Induced Pulmonary Fibrosis 2019, a5407-a5407. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5407.
Basal Epithelial Progenitor Cells for Pulmonary Engineering as Evaluated by Single-Cell TranscriptomicsGreaney A, Raredon M, Adams T, Schupp J, Kaminski N, Niklason L. Basal Epithelial Progenitor Cells for Pulmonary Engineering as Evaluated by Single-Cell Transcriptomics 2019, a5890-a5890. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5890.
A Novel Interface for Sharing the Human Cell IPF AtlasNeumark N, Adams T, Schupp J, Yan X, Poli De Frias S, Kaminski N. A Novel Interface for Sharing the Human Cell IPF Atlas 2019, a6076-a6076. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6076.
Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic ImplicationsAhangari F, Price N, Schupp J, Rose K, Ibarra G, DeIuliis G, Xylourgidis N, Prasse A, Fernandez-Hernando C, Kaminski N. Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic Implications 2019, a7222-a7222. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7222.
The Prognostic Value of Monocyte Count in Idiopathic Pulmonary Fibrosis: A Multi-Omic Cohort StudyScott M, Quinn K, Li Q, Carroll R, Chen S, Carns M, Aren K, Sun J, Koloms K, Lee J, Kropski J, Zhao H, Herzog E, Martinez F, Moore B, Hinchcliff M, Denny J, Kaminski N, Herazo-Maya J, Shah N, Khatri P. The Prognostic Value of Monocyte Count in Idiopathic Pulmonary Fibrosis: A Multi-Omic Cohort Study 2019, a7342-a7342. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7342.
Evolving Genomics of Pulmonary FibrosisIbarra G, Herazo-Maya J, Kaminski N. Evolving Genomics of Pulmonary Fibrosis 2018, 207-239. DOI: 10.1007/978-3-319-99975-3_9.
Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosisTzouvelekis A, Karampitsakos T, Min K, Xylourgidis N, Yu G, Herazo-Maya J, Bizenhofer L, Bennett A, Kaminski N. Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis 2018, lsc-1111. DOI: 10.1183/13993003.congress-2018.lsc-1111.
MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signallingTzouvelekis A, Xylourgidis N, Min K, Karampitsakos T, Ninou I, Barbayianni I, Bennett A, Aidinis V, Kaminski N. MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signalling 2018, oa5350. DOI: 10.1183/13993003.congress-2018.oa5350.
BAL cell transcriptome predicts survival in IPF and can be used to gauge and model treatment effects interfering with the TGF-beta pathwayPrasse A, Carleo A, Jaeger B, Schupp J, Rottoli P, Wuyts W, Kaminski N. BAL cell transcriptome predicts survival in IPF and can be used to gauge and model treatment effects interfering with the TGF-beta pathway 2018, oa5359. DOI: 10.1183/13993003.congress-2018.oa5359.
BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammationKhanal S, Niu N, Huleihel L, Herazo-Maya J, Kaminski N, Cohn L, Britto C. BPI Fold-Containing Family A Member 1 (BPIFA1) regulates lung neutrophil recruitment and interferon signaling during acute inflammation 2018, pa4254. DOI: 10.1183/13993003.congress-2018.pa4254.
Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomesKraft M, Ledford J, Gozdz J, Li X, Francisco D, Manne A, Guerra S, Martinez F, Kaminski N, Wenzel S, Meyers D, Bleecker E. Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomes 2018, pa5496. DOI: 10.1183/13993003.congress-2018.pa5496.
Fk506-binding protein 11, a plasma cell-specific protein folding catalyst, is increased in pulmonary fibrosisPreisendoerfer S, Knüppel L, Binzenhöfer L, Fernandez I, Juan-Guardela B, Hatz R, Behr J, Kaminski N, Schepers A, Eickelberg O, Staab-Weijnitz C. Fk506-binding protein 11, a plasma cell-specific protein folding catalyst, is increased in pulmonary fibrosis Pneumologie 2018, 72: s115-s115. DOI: 10.1055/s-0037-1619433.
Consensus network analysis reveals pathways associated with lung function decline in both COPD and IPFMcdonough J, Vanaudenaerde B, Wuyts W, Kaminski N. Consensus network analysis reveals pathways associated with lung function decline in both COPD and IPF 2017, pa3484. DOI: 10.1183/1393003.congress-2017.pa3484.
Decreased expression of FENDRR, a lung mesenchymal long non-coding RNA, regulates fibroblast phenotypes in IPF through NOX4Sakamoto K, Xylourgidis N, Omote N, Adams T, Yu G, Ahangari F, Herazo-Maya J, Kaminski N, Homer R. Decreased expression of FENDRR, a lung mesenchymal long non-coding RNA, regulates fibroblast phenotypes in IPF through NOX4 2017, oa2909. DOI: 10.1183/1393003.congress-2017.oa2909.
LSC - 2017 - Hippo-YAP/TAZ signaling is deranged in IPFWagner D, Alsafadi H, Mutze K, Costa R, Stein M, Schiller H, Kaminski N, Koenigshoff M. LSC - 2017 - Hippo-YAP/TAZ signaling is deranged in IPF 2017, oa475. DOI: 10.1183/1393003.congress-2017.oa475.
Feasibility, distribution, and efficacy of an inhaled oligonucleotide mimic of miR-29 for pulmonary fibrosis induced by bleomycin in ratsMontgomery R, Yu G, Ahangari F, Herazo-Maya J, Pestano L, Dalby C, Dickinson B, Nicholas C, Gallant-Behm C, Brower J, Kuehl P, McDonald J, Kaminski N. Feasibility, distribution, and efficacy of an inhaled oligonucleotide mimic of miR-29 for pulmonary fibrosis induced by bleomycin in rats 2017, pa3480. DOI: 10.1183/1393003.congress-2017.pa3480.
Insights from RNA-sequencing of bronchoalveolar lavage cells in a large sarcoidosis cohortVukmirovic M, Yan X, Gibson K, Gulati M, DeIuliis G, Woolard T, Adams T, Hu B, Zang W, Mihaljinec A, Luijk H, Aurelien N, O'Neal S, Becich M, Hochheiser H, Herzog E, Senior R, Chen E, Morris A, Leader J, Zhang Y, “Skip” Garcia J, Wisniewski S, Benos P, Maier L, Moller D, Drake W, Koth L, Kaminski N. Insights from RNA-sequencing of bronchoalveolar lavage cells in a large sarcoidosis cohort 2017, oa2907. DOI: 10.1183/1393003.congress-2017.oa2907.
Chapter 7 MicroRNAs in Idiopathic Pulmonary Fibrosis Partners in Health and DiseasePandit K, Kaminski N. Chapter 7 MicroRNAs in Idiopathic Pulmonary Fibrosis Partners in Health and Disease 2017, 179-202. DOI: 10.1016/b978-0-12-800553-8.00007-x.
SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosisTzouvelekis A, Yu G, Herazo-Maya J, Woolard T, Zhang Y, Lee H, Lee P, Herzog E, Bennett A, Kaminski N. SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosis 2016, oa4979. DOI: 10.1183/13993003.congress-2016.oa4979.
Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cellsTzouvelekis A, Yu G, Herazo-Maya J, Wang R, Werneck de Castro J, DeIuliis G, Ahangari F, Woolard T, Arrojo e Drigo R, Homer R, Srivastava A, Herzog E, Lee P, Bianco A, Kaminski N. Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells 2016, pa780. DOI: 10.1183/13993003.congress-2016.pa780.
P049 Loss of Twist1 in Colα2(I)+ Cells Promotes Increased Fibrosis in Experimental Lung Injury Through C-X-C Motif Ligand 12 (CXCL12)Tan J, Tedrow J, Nouraie M, Dutta J, Chu Y, Ramani K, Biswas P, Juan-guardela B, Kaminski N, Zhang Y, Kass D. P049 Loss of Twist1 in Colα2(I)+ Cells Promotes Increased Fibrosis in Experimental Lung Injury Through C-X-C Motif Ligand 12 (CXCL12) QJM 2016, 109: s37-s38. DOI: 10.1093/qjmed/hcw124.021.
Alterations in Gene Expression and DNA Methylation during Murine and Human Lung Alveolar SeptationCuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman D, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani T, Ambalavanan N. Alterations in Gene Expression and DNA Methylation during Murine and Human Lung Alveolar Septation Pediatrics 2016, 137: 434a-434a. DOI: 10.1542/peds.137.supplement_3.434a.
Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary HypertensionFares W, Pandit K, Kaminski N. Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension 2016, 123-133. DOI: 10.1007/978-3-319-23594-3_7.
Genomics of Lung Aging and Idiopathic Pulmonary FibrosisJuan-Guardela B, Kaminski N. Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis 2015, 389-408. DOI: 10.1142/9789814635011_0015.
Genomics of lung fibrosisSelman M, Pardo A, Sakamoto K, Kaminski N. Genomics of lung fibrosis 2015, 6-20. DOI: 10.2217/fmeb2013.14.118.
Palliative Care and Location of Death in Decedents With Idiopathic Pulmonary FibrosisLindell KO, Liang Z, Hoffman LA, Rosenzweig MQ, Saul MI, Pilewski JM, Gibson KF, Kaminski N. Palliative Care and Location of Death in Decedents With Idiopathic Pulmonary Fibrosis CHEST Journal 2015, 147: 423-429. PMID: 25187973, PMCID: PMC4314817, DOI: 10.1378/chest.14-1127.
T-RECS: STABLE SELECTION OF DYNAMICALLY FORMED GROUPS OF FEATURES WITH APPLICATION TO PREDICTION OF CLINICAL OUTCOMESAltman R, Dunker A, Hunter L, Ritchie M, Murray T, Klein T, HUANG G, TSAMARDINOS I, RAGHU V, KAMINSKI N, BENOS P. T-RECS: STABLE SELECTION OF DYNAMICALLY FORMED GROUPS OF FEATURES WITH APPLICATION TO PREDICTION OF CLINICAL OUTCOMES Biocomputing 2014, 20: 431-42. PMID: 25592602, PMCID: PMC4299881, DOI: 10.1142/9789814644730_0041.
Bronchial Epithelial Cell Gene Expression In Relation To Exhaled Nitric Oxide Identifies New Molecular Asthma PhenotypesModena B, Tedrow J, Milosevic J, Kaminski N, Wenzel S. Bronchial Epithelial Cell Gene Expression In Relation To Exhaled Nitric Oxide Identifies New Molecular Asthma Phenotypes Journal Of Allergy And Clinical Immunology 2014, 133: ab176. DOI: 10.1016/j.jaci.2013.12.632.
OmicsKass D, Kaminski N. Omics 2013, 179-187. DOI: 10.1183/1025448x.10045712.
Erratum: Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosisFingerlin T, Murphy E, Zhang W, Peljto A, Brown K, Steele M, Loyd J, Cosgrove G, Lynch D, Groshong S, Collard H, Wolters P, Bradford W, Kossen K, Seiwert S, du Bois R, Garcia C, Devine M, Gudmundsson G, Isaksson H, Kaminski N, Zhang Y, Gibson K, Lancaster L, Cogan J, Mason W, Maher T, Molyneaux P, Wells A, Moffatt M, Selman M, Pardo A, Kim D, Crapo J, Make B, Regan E, Walek D, Daniel J, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen B, Talbert J, Kidd R, Markin C, Beckman K, Lathrop M, Schwarz M, Schwartz D. Erratum: Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis Nature Genetics 2013, 45: 1409-1409. DOI: 10.1038/ng1113-1409a.
A Peripheral Blood Biomarker Signature Potentially Identifies Smokers with Interstitial Lung AbnormalitiesPatel A, Doyle T, Liu Y, Hatabu H, Hatabu M, Okajima Y, Risquez C, Shi Y, Osorio J, Golzarri M, Lederer J, El-Chemaly S, Pinto-Plata V, Celli B, Hunninghake G, Washko G, Sciurba F, Kaminski N, Leader J, Siegfried J, Weissfeld J, Rosas I. A Peripheral Blood Biomarker Signature Potentially Identifies Smokers with Interstitial Lung Abnormalities CHEST Journal 2013, 144: 1029a-1029b. DOI: 10.1378/chest.1778676.
Evolving Genomics of Pulmonary FibrosisHerazo-Maya J, Kaminski N. Evolving Genomics of Pulmonary Fibrosis 2013, 379-402. DOI: 10.1007/978-1-62703-682-5_19.
Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-SeqKusko R, Brothers J, Liu G, Luo L, Guardela B, Tedrow J, Aleksyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Lenburg M, Schwartz D, Beane J, Kaminski N, Spira A. Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-Seq BMC Proceedings 2012, 6: p21. PMCID: PMC3467575, DOI: 10.1186/1753-6561-6-s6-p21.
Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencingBrothers J, Kusko R, Liu G, Luo L, Guardela B, Tedrow J, Alekesyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Sebastiani P, Lenburg M, Kaminski N, Schwartz D, Spira A, Beane J. Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing BMC Proceedings 2012, 6: p4. PMCID: PMC3467663, DOI: 10.1186/1753-6561-6-s6-p4.
Characterizing the small RNA transcriptome associated with COPD and ILD using next-generation sequencingCampbell J, Luo L, Liu G, Xiao J, Gerrein J, Guardela B, Tedrow J, Aleksyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz D, Kaminski N, Lenburg M, Beane J, Spira A. Characterizing the small RNA transcriptome associated with COPD and ILD using next-generation sequencing BMC Proceedings 2012, 6: p6. PMCID: PMC3467555, DOI: 10.1186/1753-6561-6-s6-p6.
Evidence For A Th2 Phenotype Across The Spectrum Of Asthma SeverityBhakta N, Solberg O, Nguyen C, Peng J, Wang T, Nguyen C, Arron J, Fahy J, Bleecker E, Meyers D, Erzurum S, Busse W, Kaminski N, Wenzel S, Woodruff P. Evidence For A Th2 Phenotype Across The Spectrum Of Asthma Severity 2012, a2193-a2193. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2193.
Smoke-Induced MiRNA Expression Profiles Of Type II Cells Differ From Total Lung And MacrophagesDegar A, Pandit K, Kenche H, Perry Y, Kaminski N, Blumental-Perry A. Smoke-Induced MiRNA Expression Profiles Of Type II Cells Differ From Total Lung And Macrophages 2012, a2016-a2016. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2016.
CLF1 Gene Expression Is Increased In Lung Injury And DevelopmentKass D, Yu G, Kahloon R, Scheller E, Huleihel L, Deiuliis G, Tedrow J, Guardela B, Leader J, Pandit K, Milosevic J, Alcorn J, Kaminski N. CLF1 Gene Expression Is Increased In Lung Injury And Development 2012, a5546-a5546. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5546.
Translational Value Of The Bleomycin Rat Model For The Treatment Of Patients With Idiopathic Pulmonary Fibrosis (IPF)Bauer Y, Gibson K, Guardella B, Hess P, Klenk A, Lindell K, Renault B, Rey M, Tedrow J, Weber E, Kaminski N, Nayler O. Translational Value Of The Bleomycin Rat Model For The Treatment Of Patients With Idiopathic Pulmonary Fibrosis (IPF) 2012, a6241-a6241. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6241.
Age-Related Changes In The Relative Expression Of Functional Genes In Mesenchymal Stem CellsBustos M, Kapetanaki M, Meyer M, Donnenberg A, Donnenberg V, Sciurba J, Mroz L, Kaminski N, Rojas M. Age-Related Changes In The Relative Expression Of Functional Genes In Mesenchymal Stem Cells 2012, a5289-a5289. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5289.
Does The Oxygen Prescription Match The Study Results?: A Prospective Study Of Patients In A Speciality Interstitial Lung Disease CenterPagnotta E, MacPherson M, Gibson K, Kaminski N, Lindell K. Does The Oxygen Prescription Match The Study Results?: A Prospective Study Of Patients In A Speciality Interstitial Lung Disease Center 2012, a1490-a1490. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1490.
Over Expression Of MiRNA In Mesenchymal Stem Cells Alters Their Anti-Fibrotic PropertiesHuleihel L, Bustos M, DeIuliis G, Manor E, Chensny L, Mora A, Rojas M, Kaminski N. Over Expression Of MiRNA In Mesenchymal Stem Cells Alters Their Anti-Fibrotic Properties 2012, a3513-a3513. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3513.
Genome-Wide DNA Methylation Patterns In Interstitial Lung Disease (ILD) And Chronic Obstructive Lung Disease (COPD)Yang I, Pedersen B, Hennessy C, Davidson E, Bonney M, Leach S, Brown J, Turner J, Guardela B, Tedrow J, Correll M, Geraci M, Kaminski N, Quackenbush J, Sciurba F, Spira A, Schwartz D. Genome-Wide DNA Methylation Patterns In Interstitial Lung Disease (ILD) And Chronic Obstructive Lung Disease (COPD) 2012, a2667-a2667. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2667.
Global Gene Expression Of Bronchoalveolar Lavage (BAL) Cells And Peripheral Blood Mononuclear Cells (PBMCs) In IPF PatientsVuga L, Richards T, Tedrow J, Sciurba J, Autore K, Kaminski N, Prasse A. Global Gene Expression Of Bronchoalveolar Lavage (BAL) Cells And Peripheral Blood Mononuclear Cells (PBMCs) In IPF Patients 2012, a2661-a2661. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2661.
Role Of DIO2 In Idiopathic Pulmonary FibrosisYu G, Tedrow J, Rabinovich E, Drigo R, Gibson K, Yousem S, Richards T, Chensny L, Bianco A, Kaminski N. Role Of DIO2 In Idiopathic Pulmonary Fibrosis 2012, a4932-a4932. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4932.
Characterizing The Small RNA Transcriptome Associated With COPD And ILD Using Next Generation SequencingCampbell J, Luo L, Xiao J, Liu G, Gerrein J, Juan-Guardela B, Tedrow J, Aleksyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz D, Kaminski N, Lenburg M, Beane J, Spira A. Characterizing The Small RNA Transcriptome Associated With COPD And ILD Using Next Generation Sequencing 2012, a5001-a5001. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5001.
Changes In Expression Of Argonaut Proteins In IPFRabinovich E, Yu G, Kapetanaki M, Schneider F, Kaminski N. Changes In Expression Of Argonaut Proteins In IPF 2012, a3473-a3473. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3473.
Defective DNA Repair On The Ercc1-/Mice Causes Accelerated Aging And Increased Susceptibility To Lung Injury And FibrosisBustos M, Bueno M, Robison A, Sciurba J, Mroz L, Niedernhofer L, Mora A, Kaminski N, Rojas M. Defective DNA Repair On The Ercc1-/Mice Causes Accelerated Aging And Increased Susceptibility To Lung Injury And Fibrosis 2012, a5283-a5283. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5283.
Identification Of Biomarkers To Monitor The Activity Of STX-100, A Humanized Anti-±v²6 Antibody, In A Phase 2a Trial In Idiopathic Pulmonary FibrosisViolette S, Sheppard D, Rosas I, Arjomandi M, Rice T, Gilman M, Kaminski N, Prasse A, Maroni B. Identification Of Biomarkers To Monitor The Activity Of STX-100, A Humanized Anti-±v²6 Antibody, In A Phase 2a Trial In Idiopathic Pulmonary Fibrosis 2012, a2659-a2659. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2659.
Cartilage Oligomeric Matrix Protein Is Upregulated And Modulates TGF-² Signaling In Idiopathic Pulmonary FibrosisLouis V, Milosevic J, Pandit K, Ben-Yehudah A, Richards T, Choi J, Sciurba J, Zhang Y, Myerburg M, Parwani A, Gibson K, Kaminski N. Cartilage Oligomeric Matrix Protein Is Upregulated And Modulates TGF-² Signaling In Idiopathic Pulmonary Fibrosis 2012, a5560-a5560. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5560.
The LIM Protein Zyxin Modulates TGF²1-Induced Alveolar Epithelial Cell Motility Via Integrin ±5²1Mise N, Yu H, Kaminski N, Eickelberg O. The LIM Protein Zyxin Modulates TGF²1-Induced Alveolar Epithelial Cell Motility Via Integrin ±5²1 2012, a5563-a5563. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5563.
The Wnt Co-Receptors, LRP5/6, Contribute To Fibrosis In Mice And MenLam A, Sennello J, Herazo-Maya J, Flozak A, Russell S, Kaminski N, Gottardi C. The Wnt Co-Receptors, LRP5/6, Contribute To Fibrosis In Mice And Men 2012, a3919-a3919. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3919.
High Fat Diet Protects Mice From Cigarette Smoke-Induced Emphysema In Part By Altering Let 7b MicroRNA And Subsequent Oncostatin SignalingTakahashi S, Pandit K, Kaminski N, Shapiro S. High Fat Diet Protects Mice From Cigarette Smoke-Induced Emphysema In Part By Altering Let 7b MicroRNA And Subsequent Oncostatin Signaling 2012, a3754-a3754. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3754.
Identification Of Lung Disease-Associated Novel Transcripts And Alternative Splicing By RNA-SequencingBrothers J, Kusko R, Liu G, Luo L, Guardela B, Tedrow J, Alekseyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Sebastiani P, Lenburg M, Kaminski N, Schwartz D, Spira A, Beane J. Identification Of Lung Disease-Associated Novel Transcripts And Alternative Splicing By RNA-Sequencing 2012, a4892-a4892. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4892.
Gene Expression Of BAL Cells And PBMCs Predicts Survival Via Different Pathways In IPFPrasse A, Vuga L, Richards T, Kaminski N. Gene Expression Of BAL Cells And PBMCs Predicts Survival Via Different Pathways In IPF 2012, a2660-a2660. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2660.
Molecular Pathways Associated With Autoimmunity In Patients With Idiopathic Pulmonary FibrosisVij R, Huang Y, Ma S, Broderick S, White S, Strek M, Kaminski N, Garcia J, Noth I. Molecular Pathways Associated With Autoimmunity In Patients With Idiopathic Pulmonary Fibrosis 2012, a5175-a5175. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5175.
Elevated PTX3 Expression Is Specific For Emphysema Severity In Lung Tissue And Plasma Of Patients With COPDTedrow J, Juan-Guardela B, Zhang Y, Kass D, Kahloon R, Leader J, Shapiro S, Geraci M, Quackenbush J, Schwartz D, Spira A, Sciurba F, Kaminski N. Elevated PTX3 Expression Is Specific For Emphysema Severity In Lung Tissue And Plasma Of Patients With COPD 2012, a1002-a1002. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1002.
The Expression Of Long Intergenic Noncoding RNAs In Idiopathic Pulmonary Fibrosis And Their Possible Role As Suppressors Of ProliferationGuardela B, Herazo J, Tedrow J, Chensny L, Richards T, Spira A, Correll M, Quackenbush J, Geraci M, Schwartz D, Sciurba F, Gibson K, Pandit K, Kaminski N. The Expression Of Long Intergenic Noncoding RNAs In Idiopathic Pulmonary Fibrosis And Their Possible Role As Suppressors Of Proliferation 2012, a3507-a3507. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3507.
Comprehensive Genomic Profiling Of The Lung Transcriptome In Emphysema And IPF Using RNA-SeqKusko R, Brothers J, Liu G, Luo L, Guardela B, Tedrow J, Aleksyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Lenburg M, Schwartz D, Beane J, Kaminski N, Spira A. Comprehensive Genomic Profiling Of The Lung Transcriptome In Emphysema And IPF Using RNA-Seq 2012, a2664-a2664. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2664.
Association Of Plasma Levels Of PTX3 With Clinical Phenotypes Of Chronic Obstructive Pulmonary DiseaseZhang Y, Tedrow J, Zeng Q, Bon J, Chu Y, Duncan S, Weissfeld J, Leader K, Fuhrman C, Branch R, Porter M, Kaminski N, Sciurba F. Association Of Plasma Levels Of PTX3 With Clinical Phenotypes Of Chronic Obstructive Pulmonary Disease 2012, a2670-a2670. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2670.
Mimicry Of MiR-29 Attenuates Pulmonary Fibrosis Induced By Bleomycin In MiceYu G, Pandit K, Milosevic J, Montgomery R, Rooij E, Chensny L, Kaminski N. Mimicry Of MiR-29 Attenuates Pulmonary Fibrosis Induced By Bleomycin In Mice 2012, a4986-a4986. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4986.
Gender Effects On Pre- And Post-Transplant Survival In Idiopathic Pulmonary FibrosisRichards T, Kass D, Lindell K, Kaminski N, Gibson K. Gender Effects On Pre- And Post-Transplant Survival In Idiopathic Pulmonary Fibrosis 2012, a3766-a3766. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3766.
Epithelial Microarray Studies From The Severe Asthma Research Program (SARP)Wenzel S, Kang D, Kaminski N, Milosevic J, Trudeau J, Meyers D, Bleecker E, Busse W, Erzurum S, Woodruff P. Epithelial Microarray Studies From The Severe Asthma Research Program (SARP) 2012, a2510-a2510. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2510.
Hypomethylation Of LINE-1 Repeats Is A Predictor Of Carcinogenic Transformation In Normal Histology Lung TissueRabinovich E, Tedrow J, Schwartz D, Spira A, Quackenbush J, Geraci M, Sciurba F, Guardela B, Pandit K, Zhang Y, Kaminski N. Hypomethylation Of LINE-1 Repeats Is A Predictor Of Carcinogenic Transformation In Normal Histology Lung Tissue 2012, a3487-a3487. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3487.
Abstract 1720: Validation of a 15-gene prognostic signature in stage IB non small-cell lung cancer (NSCLC)Pancoska P, Romkes M, Nukui T, Buch S, Herazo-Maya J, Kaminski N, Dacic S, Weissfeld J, Bigbee W, Shapiro S, Siegfried J. Abstract 1720: Validation of a 15-gene prognostic signature in stage IB non small-cell lung cancer (NSCLC) Cancer Research 2012, 72: 1720-1720. DOI: 10.1158/1538-7445.am2012-1720.
Abstract 1722: Prognostic markers in early stage non small-cell lung cancer (NSCLC)Romkes M, Nukui T, Buch S, Pancoska P, Herazo-Maya J, Kaminski N, Dacic S, Weissfeld J, Bigbee W, Shapiro S, Siegfried J. Abstract 1722: Prognostic markers in early stage non small-cell lung cancer (NSCLC) Cancer Research 2012, 72: 1722-1722. DOI: 10.1158/1538-7445.am2012-1722.
Abstract 4937: Factors in NSCLC stage and outcome: Integrated genome-wide studyPancoska P, Romkes M, Nukui T, Buch S, Herazo-Maya J, Kaminski N, Dacic S, Weissfeld J, Bigbee W, Siegfried J. Abstract 4937: Factors in NSCLC stage and outcome: Integrated genome-wide study Cancer Research 2012, 72: 4937-4937. DOI: 10.1158/1538-7445.am2012-4937.
The LIM protein zyxin modulates TGF-β1-induced cell migrationMiše N, Yu H, Kaminski N, Eickelberg O. The LIM protein zyxin modulates TGF-β1-induced cell migration Pneumologie 2011, 65 DOI: 10.1055/s-0031-1296127.
Microrna Expression Profiles In EmphysemaTedrow J, Juan-Guardela B, Pandit K, Gur D, Leader J, Landreneau R, Schwartz D, Geraci M, Quackenbush J, Correll M, Richards T, Chensny L, Spira A, Sciurba F, Kaminski N. Microrna Expression Profiles In Emphysema 2011, a4099-a4099. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4099.
Divergent And Convergent Gene Expression Patterns In Well Phenotyped Patients With COPD And IPFTedrow J, Juan-Guardela B, Gur D, Leader J, Schwartz D, Spira A, Geraci M, Quackenbush J, Correll M, Richards T, Chensny L, Shapiro S, Vuga L, Sciurba F, Kaminski N. Divergent And Convergent Gene Expression Patterns In Well Phenotyped Patients With COPD And IPF 2011, a2274-a2274. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2274.
High-Throughput Sequencing Of MicroRNA In Idiopathic Pulmonary FibrosisRakova I, Kapetanaki M, Pandit K, Chensny L, Gibson K, Ghedin E, Kaminski N. High-Throughput Sequencing Of MicroRNA In Idiopathic Pulmonary Fibrosis 2011, a5538-a5538. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5538.
The HLA Class II Allele DRB1*1501 Is Over-Represented In Patients With Idiopathic Pulmonary FibrosisXue J, Gochuico B, Feghali-Bostwick C, Noth I, Nathan S, Rosen G, Rosas I, Gibson K, Kaminski N, Sciurba F, Zhang Y, Duncan S. The HLA Class II Allele DRB1*1501 Is Over-Represented In Patients With Idiopathic Pulmonary Fibrosis 2011, a4272-a4272. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4272.
A Variant In The Promoter Of MUC5B Is Associated With Idiopathic Pulmonary Fibrosis And Not Chronic Obstructive Pulmonary DiseaseZhang Y, Noth I, Gibson K, Ma S, Richards T, Bon J, Lindell K, Branch R, Nicolae D, Sciurba F, Garcia A, Kaminski N. A Variant In The Promoter Of MUC5B Is Associated With Idiopathic Pulmonary Fibrosis And Not Chronic Obstructive Pulmonary Disease 2011, a6395-a6395. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6395.
Identifying Novel Transcripts And Alternative Splicing Associated With The ILD And COPD Lung Transcriptome Using MRNA-SeqBrothers J, Kusko R, Luo L, Liu G, Guardela B, Tedrow J, Alekseyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Sebastiani P, Lenburg M, Kaminski N, Schwartz D, Spira A, Beane J. Identifying Novel Transcripts And Alternative Splicing Associated With The ILD And COPD Lung Transcriptome Using MRNA-Seq 2011, a5540-a5540. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5540.
Genome Wide Association Study In Idiopathic Pulmonary Fibrosis Identifies LCLAT1 As A Novel Candidate GeneNoth I, Zhang Y, Barber M, Gibson K, Ma S, Lindell K, Kaminski N, Hysi P, Nicolae D, Garcia J. Genome Wide Association Study In Idiopathic Pulmonary Fibrosis Identifies LCLAT1 As A Novel Candidate Gene 2011, a2266-a2266. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2266.
Whole Transcriptome Study Of Mesenchymal Stem Cell Response To TGF-Beta 1Kapetanaki M, Gupta N, Chensny L, Rojas M, Benos P, Kaminski N. Whole Transcriptome Study Of Mesenchymal Stem Cell Response To TGF-Beta 1 2011, a6007-a6007. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6007.
Characterizing The Lung Disease Transcriptome With Next Generation Rna-SequencingKusko R, Beane J, Brothers J, Liu G, Luo L, Guardela B, Tedrow J, Aleksyev Y, Yang I, Correll M, Geraci M, Quackenbush J, Sciurba F, Lenburg M, Schwartz D, Kaminski N, Spira A. Characterizing The Lung Disease Transcriptome With Next Generation Rna-Sequencing 2011, a5539-a5539. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5539.
Pulmonary Fibroblast Thy-1 Expression Modulates Elastin Expression During Alveolarization - In Part Via Rhoa Activation Of JNKVarisco B, Hagood J, Kaminski N, Whitsett J. Pulmonary Fibroblast Thy-1 Expression Modulates Elastin Expression During Alveolarization - In Part Via Rhoa Activation Of JNK 2011, a3492-a3492. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3492.
Decreased Survival Of Idiopathic Pulmonary Fibrosis Patients With Heat Shock Protein 70 AutoreactivityXue J, Kahloon R, Bhargava A, Banga G, Gochuico B, Dacic S, Gibson K, Kaminski N, Sciurba F, Rosas I, Otterbein L, Zhang Y, Duncan S. Decreased Survival Of Idiopathic Pulmonary Fibrosis Patients With Heat Shock Protein 70 Autoreactivity 2011, a4275-a4275. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4275.
Peripheral Blood Monuclear Cells Gene Expression Patterns Predict Mortality In Patients With Idiopathic Pulmonary FibrosisHerazo J, Gibson K, Juan-Guardela B, Ma S, Richards T, Lussier Y, Duncan S, Tseng G, Lindell K, Garcia J, Noth I, Kaminski N. Peripheral Blood Monuclear Cells Gene Expression Patterns Predict Mortality In Patients With Idiopathic Pulmonary Fibrosis 2011, a5306-a5306. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5306.
Unsupervised Combination Of Clinical And Gene Expression Data Elucidates Intermediate Phenotypes In Ild And COPDKang D, Tedrow J, Richards T, Schwartz D, Schwarz M, Martinez F, Limper A, Quackenbush J, Geraci M, Bartholmai B, Spira A, Tseng G, Sciurba F, Kaminski N. Unsupervised Combination Of Clinical And Gene Expression Data Elucidates Intermediate Phenotypes In Ild And COPD 2011, a4087-a4087. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4087.
Gene Expression Of Pneumocystis Jirovecii Infection In COPD LungsFitzpatrick M, Tedrow J, Hillenbrand M, Lucht L, Richards T, Zhang Y, Kaminski N, Sciurba F, Morris A. Gene Expression Of Pneumocystis Jirovecii Infection In COPD Lungs 2011, a4144-a4144. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4144.
Genome-Wide DNA Methylation Patterns In Interstitial Lung Disease (ild) And Chronic Obstructive Lung Disease (COPD)Yang I, Hennessy C, Davidson E, Bonney M, Leach S, Brown J, Turner J, Guardela B, Tedrow J, Correll M, Geraci M, Kaminski N, Quackenbush J, Sciurba F, Spira A, Schwartz D. Genome-Wide DNA Methylation Patterns In Interstitial Lung Disease (ild) And Chronic Obstructive Lung Disease (COPD) 2011, a1049-a1049. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1049.
MRNA And MicroRNA Expression Profiles Indicate Disease Severity In Patients With Idiopathic Pulmonary FibrosisJuan-Guardela B, Tedrow J, Herazo J, Aboud C, Pandit K, Chensny L, Gur D, Leader J, Benos P, Richards T, Correll M, Quackenbush J, Geraci M, Spira A, Schwartz D, Sciurba F, Kaminski N. MRNA And MicroRNA Expression Profiles Indicate Disease Severity In Patients With Idiopathic Pulmonary Fibrosis 2011, a6005-a6005. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6005.
Somatic Mutations In The Lungs Of Patients With Idiopathic Pulmonary FibrosisYang I, Leach S, Turner J, Kummer N, Brown J, Murphy E, Farias-Hesson E, Sisneros N, Wang Z, Coldren C, Correll M, Geraci M, Kaminski N, Quackenbush J, Sciurba F, Spira A, Schwartz D. Somatic Mutations In The Lungs Of Patients With Idiopathic Pulmonary Fibrosis 2011, a5537-a5537. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5537.
Differential Expression Of Microrna In Mesenchymal Stem Cell Derived ExosomesDeIuliis G, Di Giuseppe M, Phinney D, Sala E, Kaminski N, Ortiz L. Differential Expression Of Microrna In Mesenchymal Stem Cell Derived Exosomes 2011, a3769-a3769. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3769.
Genome-Wide Analysis Of Somatic Genetic Alterations In Severe Lung DiseaseColdren C, Gao B, Rice J, Leach S, Yang I, Murphy E, Kaminski N, Quackenbush J, Schwartz D, Sciurba F, Spira A, Geraci M. Genome-Wide Analysis Of Somatic Genetic Alterations In Severe Lung Disease 2011, a5529-a5529. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5529.
Does Ambient Air Pollution Exposure Modify Longitudinal Disease Outcomes In A Cohort Of Patients With Idiopathic Pulmonary Fibrosis?Richards T, Kuhlengel T, Choi J, Kaminski N, Bascom R. Does Ambient Air Pollution Exposure Modify Longitudinal Disease Outcomes In A Cohort Of Patients With Idiopathic Pulmonary Fibrosis? 2011, a5433-a5433. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5433.
Emphysema Gene Expression SignaturesTedrow J, Juan-Guardela B, Gur D, Leader J, Schwartz D, Spira A, Geraci M, Quackenbush J, Correll M, Richards T, Chensny L, Shapiro S, Sciurba F, Kaminski N. Emphysema Gene Expression Signatures 2011, a2271-a2271. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2271.
Mir 30b As A Potential Modifier Of Fibroblasts Phenotypes In Lung FibrosisHuleihel L, Ben-Yehudah A, Manor E, Milosevic J, Benos P, Chensny L, Kaminski N. Mir 30b As A Potential Modifier Of Fibroblasts Phenotypes In Lung Fibrosis 2011, a3528-a3528. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3528.
Pulmonary Fibrosis In Response To Pharmaceutical Grade Bleomycin Is Independent Of IL-17Pociask D, Chen K, Kaminski N, Kolls J. Pulmonary Fibrosis In Response To Pharmaceutical Grade Bleomycin Is Independent Of IL-17 2011, a5982-a5982. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5982.
Cytokine-Like Factor I (CLF1) Expression Is Increased In Idiopathic Pulmonary Fibrosis (IPF) And Promotes Inflammation But Decreases Fibrosis In Bleomycin InjuryKass D, Loh K, Borczuk A, Tedrow J, Guardela B, Kaminski N, Greenberg S. Cytokine-Like Factor I (CLF1) Expression Is Increased In Idiopathic Pulmonary Fibrosis (IPF) And Promotes Inflammation But Decreases Fibrosis In Bleomycin Injury 2011, a2710-a2710. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2710.
Lysocardiolipin Acyltransferase (lycat) Is A Novel Candidate Gene In Radiation-Induced Pulmonary FibrosisMathew B, huang L, Noth I, Ma S, Kaminski N, Zhao Y, Wade M, Berdyshev E, Siegler J, Jacobson J, Weishelbaum R, Natarajan V, Garcia J. Lysocardiolipin Acyltransferase (lycat) Is A Novel Candidate Gene In Radiation-Induced Pulmonary Fibrosis 2011, a6146-a6146. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6146.
Global Microrna Profiles Of Idiopathic Pulmonary Fibrosis Lungs Indicate Reversal Of Lung DifferentiationPandit K, Milosevic J, Benos P, Coronello C, Ben-Yehudah A, Hagood J, Ambalavanan N, Kaminski N. Global Microrna Profiles Of Idiopathic Pulmonary Fibrosis Lungs Indicate Reversal Of Lung Differentiation 2011, a5528-a5528. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5528.
Characterization of Microrna Expression Profile In Platelets In Sickle Cell DiseaseJain S, Raghavachari N, Woodhouse K, Kaminski N, Gladwin M. Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease Blood 2010, 116: 2030-2030. DOI: 10.1182/blood.v116.21.2030.2030.
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosisLiu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal V, Kaminski N, Abraham E. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis Journal Of Cell Biology 2010, 190: i3-i3. DOI: 10.1083/jcb1902oia3.
Characterization Of Airway- And Distal Lung Fibroblasts Using Systems Biology ApproachesWu W, Zhou X, Hu H, Konishi K, Milosevic J, Kaminski N, Wenzel S. Characterization Of Airway- And Distal Lung Fibroblasts Using Systems Biology Approaches 2010, a6409-a6409. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6409.
Gene Expression Profiles Differentiate Human Airway From Parenchymal FibroblastsZhou X, Wu W, Hu H, Konishi K, Milosevic J, Kaminski N, Wenzel S. Gene Expression Profiles Differentiate Human Airway From Parenchymal Fibroblasts 2010, a3978-a3978. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3978.
Regulation Telomerase and Telomere Length In IPF By MicroRNAs.Singh M, Tzfati Y, Chensny L, Benos P, Kaminski N. Regulation Telomerase and Telomere Length In IPF By MicroRNAs. 2010, a2297-a2297. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2297.
Candidate Susceptibility Genes Identified By Genomewide Analysis Of Chloride-induced Acute Lung Injury In MiceLeikauf G, Pope-Varsalona H, Concel V, Liu P, Bein K, Brant K, Dopico R, Di Y, Jang A, Medvedovic M, Li Q, Vega L, Kaminski N, You M, Prows D. Candidate Susceptibility Genes Identified By Genomewide Analysis Of Chloride-induced Acute Lung Injury In Mice 2010, a5370-a5370. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5370.
Gene Expression Profiles Of Pulmonary Fibrosis Reveal Developmental Functions As Determinants That Distinguish NSIP And UIP In Interstitial PneumoniasKonishi K, Richards T, Song J, Chensny L, Lindell K, Herazo J, Zhang Y, Gibson K, Kaminski N, Kim D. Gene Expression Profiles Of Pulmonary Fibrosis Reveal Developmental Functions As Determinants That Distinguish NSIP And UIP In Interstitial Pneumonias 2010, a2492-a2492. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2492.
Peripheral Blood Biomarkers Of Acute Exacerbation In Idiopathic Pulmonary FibrosisZhang Y, Song J, Richards T, Porter M, Kaminski N, Hagerty S, Choi A, Kim D. Peripheral Blood Biomarkers Of Acute Exacerbation In Idiopathic Pulmonary Fibrosis 2010, a1118-a1118. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1118.
Combinatorial Analysis Of Secreted Plasma Proteins Is Associated With Long-term Outcome In Lung Transplant RecipientsRichards T, Choi J, Zhang Y, Kaminski N, Studer S. Combinatorial Analysis Of Secreted Plasma Proteins Is Associated With Long-term Outcome In Lung Transplant Recipients 2010, a1006-a1006. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1006.
Bronchial And Alveolar Epithelium Differentiated From Embryonic Stem CellsBen-Yehudah A, Castro C, Eisinger V, Kinney T, Kaminski N, Schatten G, Carlisle D. Bronchial And Alveolar Epithelium Differentiated From Embryonic Stem Cells 2010, a4916-a4916. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4916.
A Potential Role Of MMP19 In The Development And Progression Of Human Lung CancerYu G, Pandit K, Parwani A, Gilbert S, Ei-Hefnawy T, Richards T, Rosas I, Chensny L, Kaminski N. A Potential Role Of MMP19 In The Development And Progression Of Human Lung Cancer 2010, a4983-a4983. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4983.
The Warm Autopsy Program For Patients With Idiopathic Pulmonary FibrosisLindell K, Zellem E, Hoffman L, Richards T, Gibson K, Dhir R, Bisceglia M, Yousem S, Nichols L, Kaminski N. The Warm Autopsy Program For Patients With Idiopathic Pulmonary Fibrosis 2010, a4016-a4016. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4016.
The Pennsylvania Idiopathic Pulmonary Fibrosis (PA-IPF) State RegistryLindell K, Black T, Hoffman K, Richards T, Kaminski N, Gibson K, Tino G, Simonelli P, Bascom R, Cordova F, Patel N, Criner G. The Pennsylvania Idiopathic Pulmonary Fibrosis (PA-IPF) State Registry 2010, a2964-a2964. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2964.
Ambient Air Pollution Exposure of Patients In The Pennsylvania Idiopathic Pulmonary Fibrosis (PA-IPF) State RegistryKuhlengel T, Bascom R, Qian Z, Kaminski N, Lindell K, Tino G, Criner G, Simonelli P, Cordova F, Patel N, Gibson K. Ambient Air Pollution Exposure of Patients In The Pennsylvania Idiopathic Pulmonary Fibrosis (PA-IPF) State Registry 2010, a4618-a4618. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4618.
Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPFRichards T, Lindell K, Klesen M, Kaminski N, Zhang Y, Gibson K. Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPF 2010, a1120-a1120. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1120.
Extent And Impact Of Pulmonary Fibrosis In A Regional Health SystemLindell K, Hoffman K, Black T, Richards T, Choi J, Saul M, Kaminski N, Gibson K. Extent And Impact Of Pulmonary Fibrosis In A Regional Health System 2010, a2966-a2966. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2966.
Alternatively Activated Macrophage (M2) Marker Expression In Leukocytes During Acute Exacerbation Of COPD (AECOPD)Cornwell W, Grabianowski C, Chensny L, Gaughan J, Sciurba F, Kaminski N, Richards T, Rogers T, Criner G. Alternatively Activated Macrophage (M2) Marker Expression In Leukocytes During Acute Exacerbation Of COPD (AECOPD) 2010, a5342-a5342. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5342.
Regulation of microRNA let-7d Expression in Idiopathic Pulmonary Fibrosis.Singh M, Patel J, Majister M, Kaminski N. Regulation of microRNA let-7d Expression in Idiopathic Pulmonary Fibrosis. 2009, a3016. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3016.
Expression and Role of miR-30 in Idiopathic Pulmonary Fibrosis.Pandit K, Corcoran D, Konishi K, Benos P, Kaminski N. Expression and Role of miR-30 in Idiopathic Pulmonary Fibrosis. 2009, a5310. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5310.
The MicroRNA Let7d Causes Mesenchymal to Epithelial Transition in Human Lung Fibroblasts.Ben-Yehudah A, Yousef H, LeJeune M, Huleihel L, Takac E, Chensny L, Kaminski N. The MicroRNA Let7d Causes Mesenchymal to Epithelial Transition in Human Lung Fibroblasts. 2009, a2490. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2490.
Gene Expression Patterns of Peripheral Blood Mononuclear Cells in Patients with Idiopathic Pulmonary Fibrosis.Herazo J, Juan B, Chensny L, Richards T, Konishi K, leJeune M, Ravinovich E, Lindell K, Gibson K, Kaminski N. Gene Expression Patterns of Peripheral Blood Mononuclear Cells in Patients with Idiopathic Pulmonary Fibrosis. 2009, a2731. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2731.
Early Interstitial Lung Disease in Smokers from the PLuSS Study.Rosas I, Weissfeld J, Furman C, Gibson K, Leader J, Gur D, Tedrow J, Kaminski N, Sciurba F. Early Interstitial Lung Disease in Smokers from the PLuSS Study. 2009, a1125. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1125.
Contrasts between IPF and Mouse Models of Pulmonary Fibrosis.Kliment C, Gochuico B, Kaminski N, Rosas I, Oury T. Contrasts between IPF and Mouse Models of Pulmonary Fibrosis. 2009, a2716. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2716.
Decreased Expression of Cholesterol and Fatty Acid Synthesis Genes in Lungs of Patients with Pulmonary Fibrosis.Geyer A, Gochuico B, Kaminski N, Morse D, Rosas I. Decreased Expression of Cholesterol and Fatty Acid Synthesis Genes in Lungs of Patients with Pulmonary Fibrosis. 2009, a1912. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1912.
Association of Radiographic COPD Phenotypes with Differential Gene Expression.Tedrow J, Konishi K, Landreneau R, Luketich J, Kaminski N, Sciurba F. Association of Radiographic COPD Phenotypes with Differential Gene Expression. 2009, a2996. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2996.
The Role of miR-154 microRNA Family in IPF.Milosevic J, Pandit K, Jacobs R, Benos P, Yakhini Z, Chensny L, Kaminski N. The Role of miR-154 microRNA Family in IPF. 2009, a2732. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2732.
Expression of Alpha-Defensins in the Lungs and Peripheral Blood of Patients with Acute Exacerbations of Idiopathic Pulmonary Fibrosis.Konishi K, Gibson K, Richards T, Lindell K, Chensny L, Zhang Y, Kaminski N, Kim D. Expression of Alpha-Defensins in the Lungs and Peripheral Blood of Patients with Acute Exacerbations of Idiopathic Pulmonary Fibrosis. 2009, a3020. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3020.
Altered Immune Competence of Peripheral Blood Leukocytes during AECOPD.Cunanan, Rogers T, Ciccolella D, Grabianowski C, Chensny L, Crookshank A, Gaughan J, Sciurba F, Kaminski N, Richards T, Mamary A, Chatila W, Criner G. Altered Immune Competence of Peripheral Blood Leukocytes during AECOPD. 2009, a2975. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2975.
Cartilage Oligomeric Matrix Protein Is a Potential Biomarker for Idiopathic Pulmonary Fibrosis.Vuga L, Ben-Yehudah A, Pandit K, Zheng Y, Sciurba J, Milosevic J, Chensny L, Konishi K, Gibson K, Kaminski N. Cartilage Oligomeric Matrix Protein Is a Potential Biomarker for Idiopathic Pulmonary Fibrosis. 2009, a3487. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3487.
Positive Feedback Loop Regulates Transcription of Syndecan-2 and Multiple TGF-beta Target Genes in HL-60 Cells.Yu G, Konishi K, Herazo J, Hanley D, Pacheco G, Richards T, Kaminski N, Rosas I. Positive Feedback Loop Regulates Transcription of Syndecan-2 and Multiple TGF-beta Target Genes in HL-60 Cells. 2009, a1876. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1876.
Molecular Characterization of Early Interstitial Lung Disease in Familial Pulmonary Fibrosis.Konishi K, Gochuico B, Herazo J, Richards T, MacDonald S, Kaminski N, Rosas I. Molecular Characterization of Early Interstitial Lung Disease in Familial Pulmonary Fibrosis. 2009, a3494. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3494.
MMP activation peptide detection in biological samples as a diagnostic marker of idiopathic pulmonary fibrosisVoeghtly L, Kaminski N, Oury T. MMP activation peptide detection in biological samples as a diagnostic marker of idiopathic pulmonary fibrosis The FASEB Journal 2009, 23: 572.11-572.11. DOI: 10.1096/fasebj.23.1_supplement.572.11.
Effects of Exercise Training on Quadriceps Muscle Gene Expression in Chronic Obstructive Pulmonary Disease.RadomAizik S, Kaminski N, Hayek S, Halkin H, Cooper D, BenDov I. Effects of Exercise Training on Quadriceps Muscle Gene Expression in Chronic Obstructive Pulmonary Disease. Cardiopulmonary Physical Therapy Journal 2007, 18: 26-27. DOI: 10.1097/01823246-200718030-00009.
331: Gene expression profiles in peripheral blood for the noninvasive diagnosis of chronic lung allograft rejectionStuder S, Richards T, Wu W, McCurry K, Kaminski N. 331: Gene expression profiles in peripheral blood for the noninvasive diagnosis of chronic lung allograft rejection The Journal Of Heart And Lung Transplantation 2007, 26: s179. DOI: 10.1016/j.healun.2006.11.351.
Systemic Biomarker Pattern in Different Chronic Obstructive Pulmonary Disease Phenotypes Independent of Smoking StatusPatel S, Choi A, Zhang Y, Kaminski N, Lokshin A, Weissfeld J, Sciurba F. Systemic Biomarker Pattern in Different Chronic Obstructive Pulmonary Disease Phenotypes Independent of Smoking Status Annals Of The American Thoracic Society 2006, 3: 551-551. DOI: 10.1513/pats.200603-083ms.
RAGE: A beneficial role in pulmonary fibrosisOury T, Hanford L, Kaminski N, Fattman C, Tan R, Tobloewski J, Kasper M, Bierhaus A. RAGE: A beneficial role in pulmonary fibrosis The FASEB Journal 2006, 20: a213-a213. DOI: 10.1096/fasebj.20.4.a213.
A Patient-Gene Model for Temporal Expression Profiles in Clinical StudiesKaminski N, Bar-Joseph Z. A Patient-Gene Model for Temporal Expression Profiles in Clinical Studies 2006, 3909: 69-82. DOI: 10.1007/11732990_6.
S.16.04 Peripheral gene expression in PTSDShalev A, Segman R, Friedman N, Kaminski N, Sheffi N, Goltser-Dubner T. S.16.04 Peripheral gene expression in PTSD European Neuropsychopharmacology 2006, 16: s188. DOI: 10.1016/s0924-977x(06)70081-5.
Erratum: Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivorsSegman R, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev A. Erratum: Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors Molecular Psychiatry 2005, 10: 514-514. DOI: 10.1038/sj.mp.4001654.
Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly MenRadom-Aizik S, Hayek S, Rechavi G, Amariglio N, Halkin H, Kaminski N, Ben-Dov I. Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly Men Medicine & Science In Sports & Exercise 2005, 37: s243. DOI: 10.1097/00005768-200505001-01259.
Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly MenRadom-Aizik S, Hayek S, Rechavi G, Amariglio N, Halkin H, Kaminski N, Ben-Dov I. Training Reverses Age-Related Gene Expression Changes In Skeletal Muscle Of Elderly Men Medicine & Science In Sports & Exercise 2005, 37: s243. DOI: 10.1249/00005768-200505001-01259.
Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivorsSegman R, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev A. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors Molecular Psychiatry 2005, 10: 425-425. DOI: 10.1038/sj.mp.4001676.
The mechanisms of idiopathic pulmonary fibrosis: can we see the elephant?Gibson K, Kaminski N. The mechanisms of idiopathic pulmonary fibrosis: can we see the elephant? Drug Discovery Today Disease Mechanisms 2004, 1: 117-122. DOI: 10.1016/j.ddmec.2004.08.002.
Effects of Exercise Training on Quadriceps Muscle Gene Expression in Chronic Obstructive Pulmonary Disease.RadomAizik S, Kaminski N, Hayek S, Halkin H, Cooper D, BenDov I. Effects of Exercise Training on Quadriceps Muscle Gene Expression in Chronic Obstructive Pulmonary Disease. Cardiopulmonary Physical Therapy Journal 2004, 18: 26-27. DOI: 10.1097/01823246-200418030-00009.
Functional Genomics of Lung DiseaseWhitsett J, Bachurski C, Barnes K, Bunn P, Case L, Cook D, Crooks D, Duncan M, Dwyer-Nield L, Elston R, Fessler M, Franklin W, Friedman N, Garcia J, Geraci M, Glasgow C, Glasser S, Hardie W, Henning L, Johnson G, Kawkitinarong K, Keith R, Korfhagen T, Leikauf G, Liggett S, Malcolm K, Malkinson A, Mariani T, McDowell S, McGraw D, Medvedovic M, Moss J, Nogee L, Nonas S, Pacheco-Rodriguez G, Palmer L, Peters D, Prows D, Redline S, Regev A, Sartor M, Schwartz D, Silverman E, Steagall W, Stearman R, Taveira-DaSilva A, Tichelaar J, Tomlinson C, Tsukada K, Weaver T, Wert S, Wesselkamper S, Worthen G, Xu Y, Zerbe L, Zhang Y, Zhang Y, Choi A, Kaminski N. Functional Genomics of Lung Disease American Journal Of Respiratory Cell And Molecular Biology 2004, 31: s1-s81. PMID: 15269003, DOI: 10.1165/rcmb.2004-0071su.
Idiopathic Pulmonary FibrosisKaminski N, Belperio J, Bitterman P, Chen L, Chensue S, Choi A, Dacic S, Dauber J, du Bois R, Enghild J, Fattman C, Grutters J, Haegens A, Hanford L, Heintz N, Henson P, Hogaboam C, Kagan V, Keane M, Kunkel S, Land S, Loyd J, Lukacs N, MacPherson M, Manning B, Manning N, Martinelli M, Moller D, Morse D, Mossman B, Noble P, Nowak N, Oury T, Pardo A, Perez A, Petty T, Phan S, Ramos-Nino M, Ray P, Rogers R, Sato H, Scapoli L, Schaefer L, Selman M, Stern M, Strollo D, Tyurin V, Valnickova Z, Welsh K, Witzmann F, Yousem S, Strieter R. Idiopathic Pulmonary Fibrosis American Journal Of Respiratory Cell And Molecular Biology 2003, 29: s1-s105. PMID: 12936907, DOI: 10.1165/rcmb.2003-0159su.
Use of Oligonucleotide Microarrays to Analyze Gene Expression Patterns in Pulmonary Fibrosis Reveals Distinct Patterns of Gene Expression in Mice and HumansKaminski N. Use of Oligonucleotide Microarrays to Analyze Gene Expression Patterns in Pulmonary Fibrosis Reveals Distinct Patterns of Gene Expression in Mice and Humans CHEST Journal 2002, 121: 31s-a-32. DOI: 10.1378/chest.121.3_suppl.31s-a.
Statistical Methods for Analyzing Gene Expression Data for Cancer ResearchFriedman N, Kaminski N. Statistical Methods for Analyzing Gene Expression Data for Cancer Research 2002, 109-131. DOI: 10.1007/978-3-662-04747-7_6.
Lung inflammation induced by mixed T cell responses: Critical mediatorsHwang J, Yen D, Shahar I, Rennick D, Donaldson D, Kaminski N, Grunig G. Lung inflammation induced by mixed T cell responses: Critical mediators Journal Of Allergy And Clinical Immunology 2002, 109: s317. DOI: 10.1016/s0091-6749(02)82112-1.
Interleukin-13 Induces Dramatically Different Transcriptional Programs in Three Human Airway Cell TypesLee J, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle D, Sheppard D. Interleukin-13 Induces Dramatically Different Transcriptional Programs in Three Human Airway Cell Types American Journal Of Respiratory Cell And Molecular Biology 2001, 25: 474-485. PMID: 11694453, DOI: 10.1165/ajrcmb.25.4.4522.
TGF-β is a critical mediator of acute lung injuryPittet J, Griffiths M, Geiser T, Kaminski N, Dalton S, Huang X, Brown L, Gotwals P, Koteliansky V, Matthay M, Sheppard D. TGF-β is a critical mediator of acute lung injury Journal Of Clinical Investigation 2001, 107: 1537-1544. PMID: 11413161, PMCID: PMC200192, DOI: 10.1172/jci11963.
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1Kannan K, Kaminski N, Rechavi G, Jakob-Hirsch J, Amariglio N, Givol D. DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1 Oncogene 2001, 20: 3449-3455. PMID: 11423996, DOI: 10.1038/sj.onc.1204446.
DNA microarrays identification of primary and secondary target genes regulated by p53Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N, Getz G, Domany E, Givol D. DNA microarrays identification of primary and secondary target genes regulated by p53 Oncogene 2001, 20: 2225-2234. PMID: 11402317, DOI: 10.1038/sj.onc.1204319.
A composite genomic profile of lung cancer in smokers and nonsmokersKaminski N, Pilzer D, Cojocaru G, Margalit O, Friedman N, Reinstein S, Simansky D, Yaron P, Ninnete A, Yellin A, Rechavi G, Friedman E, Krupsky M. A composite genomic profile of lung cancer in smokers and nonsmokers Nature Genetics 2001, 27: 63-63. DOI: 10.1038/87144.
Primary and secondary target genes regulated by p53 identified by DNA microarraysKannan K, Amariglio N, Rechavi G, Yaakov Y, Kaminski N, Getz G, Domany E, Givol D. Primary and secondary target genes regulated by p53 identified by DNA microarrays Nature Genetics 2001, 27: 63-63. DOI: 10.1038/87146.
BioinformaticsKaminski N. Bioinformatics American Journal Of Respiratory Cell And Molecular Biology 2000, 23: 705-711. PMID: 11104721, DOI: 10.1165/ajrcmb.23.6.4291.
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosisKaminski N, Allard J, Pittet J, Zuo F, Griffiths M, Morris D, Huang X, Sheppard D, Heller R. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 1778-1783. PMID: 10677534, PMCID: PMC26512, DOI: 10.1073/pnas.97.4.1778.
Use of Oligonucleotide Arrays to Analyze Drug ToxicityKAMINSKI N, ALLARD J, HELLER R. Use of Oligonucleotide Arrays to Analyze Drug Toxicity Annals Of The New York Academy Of Sciences 2000, 919: 1-8. PMID: 11083091, DOI: 10.1111/j.1749-6632.2000.tb06861.x.
A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1Munger J, Huang X, Kawakatsu H, Griffiths M, Dalton S, Wu J, Pittet J, Kaminski N, Garat C, Matthay M, Rifkin D, Sheppard D. A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1 Cell 1999, 96: 319-328. PMID: 10025398, DOI: 10.1016/s0092-8674(00)80545-0.
Right-Sided Endocarditis Due to Staphylococcus aureusSchwaber M, Lossos I, Goldberg Y, Jaffe R, Kaminski N. Right-Sided Endocarditis Due to Staphylococcus aureus Infectious Diseases In Clinical Practice 1995, 4: 453-455. DOI: 10.1097/00019048-199511000-00023.
Regression of Kaposi's sarcoma after intravenous immunoglobulin treatment for polymyositisCarmeli Y, Mevorach D, Kaminski N, Raz E. Regression of Kaposi's sarcoma after intravenous immunoglobulin treatment for polymyositis Cancer 1994, 73: 2859-2861. PMID: 8194027, DOI: 10.1002/1097-0142(19940601)73:11<2859::aid-cncr2820731132>3.0.co;2-p.
Effects of Perfusion Pressure and Renal Flow upon Albumin Excretion in Isolated Perfused KidneysRaz E, Kaminski N, Brezis M. Effects of Perfusion Pressure and Renal Flow upon Albumin Excretion in Isolated Perfused Kidneys Nephron 1990, 56: 396-398. PMID: 2079998, DOI: 10.1159/000186182.

Clinical Trials

Conditions	Study Title
Diseases of the Lung	Saracatinib (AZD0530) in the Treatment of Patients with Idiopathic Pulmonary Fibrosis

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Naftali Kaminski, MD

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Thyroid Hormone effects on Mitochondria in Type II Epithelial Cells

Dr. Kaminski receiving the ERS gold Medal in London in 2017

Dr. Kaminski Receiving the Helmholtz International Award from Dr. Eickelberg in Munich, June 2013

52 Gene Signature Predictive of Outcome in 6 Cohorts of IPF Patients

Transcriptional Regulatory networks of Fibrosis Progression within the Human Lung

Cell regulatory Networks in the IPF lung

The IPF Cell Atlas

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