Laura Ment, MD
Professor of Pediatrics (Neurology); Associate Dean for Admissions and Financial Aid; Director, START Program
Research & Publications
Biography
News
Research Summary
Laura R. Ment, M.D., studies the impact of injury and recovering on developing brain in preterm neonates, fetuses with congenital heart disease and fetuses and neonates at risk for autism spectrum disorder. Dr. Ment and her colleagues employ serial neurodevelopmental outcome measures coupled with volumetric, functional and diffusion tensor imaging strategies to assess the influence of these perturbations on neural connectivity and the relationship of connectivity to outcome.
Specialized Terms: Adaptive Mechanisms of Developing Brain; Clinical Studies of Pathophysiology and Gene Targets for Prevention of Injury to Preterm Brain; Volumetric, Diffusion Tensor and Functional Imaging of Developmental Changes; Preclinical Studies in employing Animal Models of Injury and Repair in Preterm Brain with MRI, Genetic and Behavioral Assessments
Coauthors
Research Interests
Brain; Magnetic Resonance Imaging; Neurology; Pediatrics; Diffusion Tensor Imaging; Functional Neuroimaging
Selected Publications
- Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of AgeScheinost D, Chang J, Lacadie C, Brennan-Wydra E, Constable RT, Chawarska K, Ment LR. Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age. Cerebral Cortex 2021, 32: 3289-3301. PMID: 34875024, PMCID: PMC9340393, DOI: 10.1093/cercor/bhab415.
- Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonatesScheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.
- Brain injury patterns in hypoxic ischemic encephalopathy of term neonatesBobba PS, Malhotra A, Sheth KN, Taylor SN, Ment LR, Payabvash S. Brain injury patterns in hypoxic ischemic encephalopathy of term neonates. Journal Of Neuroimaging 2022, 33: 79-84. PMID: 36164277, DOI: 10.1111/jon.13052.
- Age-dependent white matter microstructural disintegrity in autism spectrum disorderWeber CF, Lake EMR, Haider SP, Mozayan A, Mukherjee P, Scheinost D, Bamford NS, Ment L, Constable T, Payabvash S. Age-dependent white matter microstructural disintegrity in autism spectrum disorder. Frontiers In Neuroscience 2022, 16: 957018. PMID: 36161157, PMCID: PMC9490315, DOI: 10.3389/fnins.2022.957018.
- Age‐related topographic map of magnetic resonance diffusion metrics in neonatal brainsBobba PS, Weber CF, Mak A, Mozayan A, Malhotra A, Sheth KN, Taylor SN, Vossough A, Grant PE, Scheinost D, Constable RT, Ment LR, Payabvash S. Age‐related topographic map of magnetic resonance diffusion metrics in neonatal brains. Human Brain Mapping 2022, 43: 4326-4334. PMID: 35599634, PMCID: PMC9435001, DOI: 10.1002/hbm.25956.
- Neuroimaging of the Preterm Brain: Review and RecommendationsInder TE, de Vries LS, Ferriero DM, Grant PE, Ment LR, Miller SP, Volpe JJ. Neuroimaging of the Preterm Brain: Review and Recommendations. The Journal Of Pediatrics 2021, 237: 276-287.e4. PMID: 34146549, DOI: 10.1016/j.jpeds.2021.06.014.
- Food Insecurity in Medical Students: Preliminary Data From Yale School of MedicineZhou AG, Mercier MR, Chan C, Criscione J, Angoff N, Ment LR. Food Insecurity in Medical Students: Preliminary Data From Yale School of Medicine. Academic Medicine 2021, 96: 774-776. PMID: 34031298, DOI: 10.1097/acm.0000000000004048.
- Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalusJin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.
- De novo damaging variants associated with congenital heart diseases contribute to the connectomeJi W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, Khokha MK, Ment LR. De novo damaging variants associated with congenital heart diseases contribute to the connectome. Scientific Reports 2020, 10: 7046. PMID: 32341405, PMCID: PMC7184603, DOI: 10.1038/s41598-020-63928-2.
- Weak functional connectivity in the human fetal brain prior to preterm birthThomason ME, Scheinost D, Manning JH, Grove LE, Hect J, Marshall N, Hernandez-Andrade E, Berman S, Pappas A, Yeo L, Hassan SS, Constable RT, Ment LR, Romero R. Weak functional connectivity in the human fetal brain prior to preterm birth. Scientific Reports 2017, 7: 39286. PMID: 28067865, PMCID: PMC5221666, DOI: 10.1038/srep39286.
- Does prenatal stress alter the developing connectome?Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatric Research 2016, 81: 214-226. PMID: 27673421, PMCID: PMC5313513, DOI: 10.1038/pr.2016.197.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Children's Health | Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE) (I-ACQUIRE) |
| Diseases of the Cardiovascular System | Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes) |