Jose Gomez Villalobos, MD, MS
Research & Publications
My research is focused on the role of microRNAs in asthma severity. MicroRNAs are key epigenetic regulators of biologic processes, we have identified a microRNA network that is associated with neutrophilic airway inflammation in asthma. We are using systems biology methods to understand the role of these microRNAs in the regulation of airway inflammation.
Extensive Research Description
Our goal is the study of pulmonary diseases using high-throughput technologies and advanced statistical methods to understand disease biology, improve disease classification, and identify therapeutic targets.
Our research in asthma incorporates multiple domains, including clinical phenotyping, computational biology and genomic methods.
My laboratory is also interested in the integration of high-throughput data generated in our laboratory and publicly accessible datasets to understand the biology of airway diseases and the fundamental molecular processes present in pulmonary diseases.
I'm a believer in interdisciplinary approaches to resolve important problems in medicine and I welcome internal and external collaborations that share this vision.
Asthma; Computational Biology; Genomics; Pulmonary Disease, Chronic Obstructive; Informatics
Public Health Interests
- A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in AsthmaGomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma American Journal Of Respiratory And Critical Care Medicine 2020, 0: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360oc.
- Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide.Precision in Pulmonary, Critical Care and Sleep Medicine. A Clinical and Research Guide. Gomez JL, Himes BE, Kaminski N. Editor. First Edition. Springer Nature Switzerland, 2020.
- Characterisation of asthma subgroups associated with circulating YKL-40 levelsGomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Characterisation of asthma subgroups associated with circulating YKL-40 levels European Respiratory Journal 2017, 50: 1700800. PMID: 29025889, PMCID: PMC5967238, DOI: 10.1183/13993003.00800-2017.
- Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of AsthmaYan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1116-1125. PMID: 25763605, PMCID: PMC4451618, DOI: 10.1164/rccm.201408-1440oc.
- Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Investigators S, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40 Journal Of Allergy And Clinical Immunology 2015, 136: 51-58.e10. PMID: 25592985, PMCID: PMC4494869, DOI: 10.1016/j.jaci.2014.11.027.
|Asthma||PrecISE: Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network|