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James E Rothman, PhD

Sterling Professor of Cell Biology and Professor of Chemistry; Director, Nanobiology Institute

Contact Information

James E Rothman, PhD

Lab Location

Mailing Address

  • Cell Biology

    333 Cedar Street, P.O. Box 208002

    New Haven, CT 06520-8002

    United States

Research Summary

We take an interdisciplinary approach, which includes cell-free biochemistry, single molecule biophysics, and super-resolution optical imaging of single events/single molecules in the cell and in cell-free formats. The overall goal is to understand transport pathways form structural mechanism to cellular physiology. We have a strong interest in new lab members who bring backgrounds in protein biochemistry, organic chemistry, biophysics, and bio-engineering.

Specialized Terms: Elucidating the underlying mechanisms of vesicular transport within cells; Secretion of hormones and neurotransmitters

Extensive Research Description

  1. The biophysical mechanisms of membrane fusion.
  2. Regulation of vesicle fusion in synaptic transmission.
  3. Structural and functional organization of the Golgi apparatus.


Research Interests

Biochemistry; Biophysics; Chemistry; Cell Biology; Golgi Apparatus; Membrane Fusion; Synaptic Transmission; Vesicular Transport Proteins

Selected Publications