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Helene Benveniste, MD, PhD

Professor of Anesthesiology

Contact Information

Helene Benveniste, MD, PhD

Office Location

Mailing Address

  • Anesthesiology

    PO Box 208051

    New Haven, CT 06520-8051

    United States

Research Summary

Currently, Dr. Benveniste's research program has several areas of focus. Foremost, she and her students, post-docs, and close scientific collaborators are interested in understanding how the brain gets rid of metabolic waste products via the ‘glymphatic system’ (GS). Benveniste is engaged in preclinical MRI studies to understand how the brain’s waste removal pathways are affected in cerebral amyloid angiopathy, AD and small vessel disease; in collaboration with MR colleagues from the MRRC. For example, she has developed imaging platforms to examine how cerebrospinal fluid (CSF) circulates in the brain and explored how several critical processes (e.g. vascular pulsatility, type of anesthesia, body position) impact waste removal across the adult lifespan. Furthermore, she has identified substantial differences in waste processing via CSF transport when the brain is exposed to lighter sedation versus deeper anesthetic states and is currently examining the sources of these differences. Second, Benveniste and her colleague Dr. Hedok Lee (MR physicist) are interested in understanding how defects in the waste clearing processes may be contributing to development of cognitive decline and dementia. To that end, they have conducted (and are in the process of conducting) preclinical experiments in transgenic rodent models of small vessel disease (vascular dementia) as well as Alzheimer’s disease. In recent studies they have discovered that the waste clearing processes appear to become defect before brain tissue loss is evident potentially reflecting the importance of the GS system as a therapeutic target in maintaining brain health across the lifespan. In addition, Benveniste has active clinical research interests in addiction to substances of abuse and is actively involved conducting several collaborative studies with colleagues at NIAAA and the University of Copenhagen in Denmark.

Coauthors

Research Interests

Anesthesia; Brain; Central Nervous System; Cerebrospinal Fluid

Selected Publications

  • Abstract WMP110: Vascular Endothelial Growth Factor C Confers Neuroprotection And Ameliorates Ischemic Stroke OutcomesSimoes Braga Boisserand L, Lee S, Bouchart J, Medeiros Geraldo L, Sanganahalli B, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. Abstract WMP110: Vascular Endothelial Growth Factor C Confers Neuroprotection And Ameliorates Ischemic Stroke Outcomes Stroke 2023, 54: awmp110-awmp110. DOI: 10.1161/str.54.suppl_1.wmp110.
  • Activation of brain arousal networks coincident with eye blinks during resting state.Demiral Ş, Kure Liu C, Benveniste H, Tomasi D, Volkow N. Activation of brain arousal networks coincident with eye blinks during resting state. Cerebral Cortex 2023 PMID: 36653022, DOI: 10.1093/cercor/bhad001.
  • CSF-to-dura gatewaysThomas J, Benveniste H. CSF-to-dura gateways Journal Of Experimental Medicine 2022, 220: e20221719. PMID: 36472584, PMCID: PMC9729850, DOI: 10.1084/jem.20221719.
  • Glymphatic SystemBenveniste H, Nedergaard M. Glymphatic System 2022, 2271-2288. DOI: 10.1007/978-3-030-88832-9_138.
  • Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteriesChen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries Nature Aging 2022, 2: 454-454. DOI: 10.1038/s43587-022-00223-x.
  • Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)Van Nostrand W, Xu F, Lee H, Robinson J, Benveniste H. Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID) Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.051368.
  • Glymphatic SystemBenveniste H, Nedergaard M. Glymphatic System 2016, 1945-1962. DOI: 10.1007/978-1-4939-3474-4_138.
  • P.1.i.012 Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depressionJørgensen A, Magnusson P, Hanson L, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen J, Fink-Jensen A, Knudsen G, Paulson O, Bolwig T, Jørgensen M. P.1.i.012 Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression European Neuropsychopharmacology 2016, 26: s304-s305. DOI: 10.1016/s0924-977x(16)31208-1.
  • The glymphatic systemBenveniste H, Nedergaard M. The glymphatic system Neurology Psychiatry And Brain Research 2016, 22: 2. DOI: 10.1016/j.npbr.2015.12.006.
  • Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depressionJorgensen A, Magnusson P, Hanson L, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen J, Fink-Jensen A, Knudsen G, Paulson O, Bolwig T, Jorgensen M. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression Acta Psychiatrica Scandinavica 2015, 133: 154-164. PMID: 26138003, DOI: 10.1111/acps.12462.
  • F2‐02‐01: Influence of body posture on brain waste removal by the glymphatic pathwayBenveniste H. F2‐02‐01: Influence of body posture on brain waste removal by the glymphatic pathway Alzheimer's & Dementia 2015, 11: p165-p165. DOI: 10.1016/j.jalz.2015.07.112.
  • On the flow dynamics of cerebrospinal fluidBechter K, Hof P, Benveniste H. On the flow dynamics of cerebrospinal fluid Neurology Psychiatry And Brain Research 2015, 21: 96-103. DOI: 10.1016/j.npbr.2015.01.001.
  • Glymphatic SystemBenveniste H, Nedergaard M. Glymphatic System 2015, 1-18. DOI: 10.1007/978-1-4614-6434-1_138-1.
  • Brain-wide glymphatic waste drainage characterized by PET-MRIBenveniste H, Budassi M, Smith S, Yu M, Lee H, Nedergaard M, Vaska P. Brain-wide glymphatic waste drainage characterized by PET-MRI Neurology Psychiatry And Brain Research 2014, 20: 4-5. DOI: 10.1016/j.npbr.2014.01.137.
  • Metabolomic Profiling of Children’s Brains Undergoing General Anesthesia With Sevoflurane and PropofolJacob Z, Li H, Makaryus R, Zhang S, Reinsel R, Lee H, Feng T, Rothman D, Benveniste H. Metabolomic Profiling of Children’s Brains Undergoing General Anesthesia With Sevoflurane and Propofol Survey Of Anesthesiology 2013, 57: 139. DOI: 10.1097/01.sa.0000428779.04189.52.
  • Characterization of Patients with Difficult-to-Treat Acute Pain Following Total Knee Arthroplasty Using Multi-Modal AnalgesiaAzim S, Sangster R, Curcio C, Coleman D, Shah U, Zhang S, Reinsel R, Glass P, Nicholson J, Benveniste H. Characterization of Patients with Difficult-to-Treat Acute Pain Following Total Knee Arthroplasty Using Multi-Modal Analgesia The Open Pain Journal 2013, 6: 1-6. DOI: 10.2174/1876386301306010001.
  • Cerebral Metabolomics Of Early Stage Lung Cancer PatientsBilfinger T, Benveniste H, Lee H, Zhang S, Li H, Reinsel R, Conrad J, Campolo S. Cerebral Metabolomics Of Early Stage Lung Cancer Patients 2011, a6104-a6104. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6104.
  • Simultaneous acquisition of MRI and PET cardiac cine 3D images at 9.4 TeslaSmith S, Maramraju S, Southekal S, Ravindranath B, Krishnamoorthy S, Purschke M, Junnarkar S, Rescia S, Schulz D, Woody C, Stoll S, Vaska P, Carrion J, Schlyer D, Benveniste H. Simultaneous acquisition of MRI and PET cardiac cine 3D images at 9.4 Tesla Journal Of Cardiovascular Magnetic Resonance 2010, 12: o59. DOI: 10.1186/1532-429x-12-s1-o59.
  • Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalusWagshul M, McAllister J, Rashid S, Li J, Egnor M, Walker M, Yu M, Smith S, Zhang G, Chen J, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus Experimental Neurology 2009, 218: 33-40. PMID: 19348801, DOI: 10.1016/j.expneurol.2009.03.034.
  • DETECTION OF Ca2+-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAINDU C, LUO Z, YU M, BENVENISTE H, TULLY M, PAN R, CHANCE B. DETECTION OF Ca2+-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN Journal Of Innovative Optical Health Sciences 2009, 2: 189-200. DOI: 10.1142/s1793545809000498.
  • 228 Functional cardiac phenotyping of vasoactive intestinal peptide (VIP) deficient mice by MR microsopySmith S, Szema A, Said S, Benveniste H. 228 Functional cardiac phenotyping of vasoactive intestinal peptide (VIP) deficient mice by MR microsopy Journal Of Cardiovascular Magnetic Resonance 2008, 10: a89. DOI: 10.1186/1532-429x-10-s1-a89.
  • Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"Djurić P, Benveniste H, Wagshul M, Henn F, Enikolopov G, Maletić-Savatić M. Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain" Science 2008, 321: 640-640. PMID: 26380846, PMCID: PMC4576718, DOI: 10.1126/science.1156889.
  • P2‐002: Detection of amyloid plaques by diffraction enhanced imaging in a mouse model of Alzheimer's diseaseConnor D, Benveniste H, Dilmanian A, Miller L, Kritzer M, Zhong Z. P2‐002: Detection of amyloid plaques by diffraction enhanced imaging in a mouse model of Alzheimer's disease Alzheimer's & Dementia 2008, 4: t366-t366. DOI: 10.1016/j.jalz.2008.05.1082.
  • IC‐P3‐175: Detection of amyloid plaques by diffraction enhanced imaging in a mouse model of Alzheimer's diseaseConnor D, Benveniste H, Dilmanian A, Miller L, Kritzer M, Zhong Z. IC‐P3‐175: Detection of amyloid plaques by diffraction enhanced imaging in a mouse model of Alzheimer's disease Alzheimer's & Dementia 2008, 4: t77-t77. DOI: 10.1016/j.jalz.2008.05.119.
  • Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker DiscoveryMaletić-Savatić M, Vingara L, Manganas L, Li Y, Zhang S, Sierra A, Hazel R, Smith D, Wagshul M, Henn F, Krupp L, Enikolopov G, Benveniste H, Djurić P, Pelczer I. Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery Cold Spring Harbor Symposia On Quantitative Biology 2008, 73: 389-401. PMID: 19022759, PMCID: PMC4037147, DOI: 10.1101/sqb.2008.73.021.
  • Detection of Ca2+- Dependent Neuronal Activity Simultaneously With Dynamic Changes in Cerebral Blood Flow, Blood Volume and Oxygenation in Somatosensory Cortex of the Live Rat BrainDu C, Luo Z, Yu M, Benveniste H. Detection of Ca2+- Dependent Neuronal Activity Simultaneously With Dynamic Changes in Cerebral Blood Flow, Blood Volume and Oxygenation in Somatosensory Cortex of the Live Rat Brain 2008, btue3. DOI: 10.1364/biomed.2008.btue3.
  • Hyperdynamic pulsatile flow and ventricular dilation in experimental communicating hydrocephalusWagshul M, Li J, Benveniste H, Egnor M, Haacke E, Rashid S, Shen Y, Walker M, Yu M, McAllister J. Hyperdynamic pulsatile flow and ventricular dilation in experimental communicating hydrocephalus Fluids And Barriers Of The CNS 2007, 4: s22. DOI: 10.1186/1743-8454-4-s1-s22.
  • Development of Ventricular Expansion and Increased Pulsatile CSF Flow in a Rat ModelRashid S, Wagshul M, Yu M, Benveniste H, Li J, McAllister J. Development of Ventricular Expansion and Increased Pulsatile CSF Flow in a Rat Model 2007, 96-97. DOI: 10.1109/nebc.2007.4413296.
  • Laser Doppler Speckle Contrast Imaging of Cerebral Blood Flow during Functional Activation in Rat Somatosensory CortexLuo Z, Benveniste H, Yu M, Pan Y, Du C. Laser Doppler Speckle Contrast Imaging of Cerebral Blood Flow during Functional Activation in Rat Somatosensory Cortex 2007, 69-70. DOI: 10.1109/nebc.2007.4413283.
  • High Resolution 3D in Vivo Mouse Brain Imaging at 9.4 T Bruker MRI SystemHamilton C, Ma Y, Smith S, Benveniste H. High Resolution 3D in Vivo Mouse Brain Imaging at 9.4 T Bruker MRI System 2007, 45-46. DOI: 10.1109/nebc.2007.4413272.
  • Cocaine-Induced Cerebral Hemodynamic and Neuronal Function Changes in Vivo Measured by Laser Doppler FlowmetryTully M, Luo Z, Benveniste H, Yu M, Du C. Cocaine-Induced Cerebral Hemodynamic and Neuronal Function Changes in Vivo Measured by Laser Doppler Flowmetry 2007, 156-158. DOI: 10.1109/nebc.2007.4413326.
  • Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-RaysAnschel D, Romanelli P, Benveniste H, Foerster B, Kalef-Ezra J, Zhong Z, Dilmanian F. Evolution of a Focal Brain Lesion Produced by Interlaced Microplanar X-Rays Min - Minimally Invasive Neurosurgery 2007, 50: 43-46. PMID: 17546543, DOI: 10.1055/s-2007-976514.
  • Local Cerebral Blood Flow Responses to Direct Stimulation in Somatosensory Cortex: Laser Doppler Flowmetric and Autoradiographic AnalysisLuo Z, Dhawan J, Benveniste H, Yu M, Gifford A, Du C. Local Cerebral Blood Flow Responses to Direct Stimulation in Somatosensory Cortex: Laser Doppler Flowmetric and Autoradiographic Analysis 2006, me17. DOI: 10.1364/bio.2006.me17.
  • Optical Approach to Detect Vascular Functional Changes Induced by Cocaine in Living Rat BrainDu C, Luo Z, Yu M, Benveniste H. Optical Approach to Detect Vascular Functional Changes Induced by Cocaine in Living Rat Brain 2006, tui5. DOI: 10.1364/bio.2006.tui5.
  • Microscopic Fluorescence Studies on Brain Intracellular Ca2+ Responses to Ischemia with and without Ca2+- Channel BlockadeDu C, Wolf A, Perez Y, Yu M, Pan Y, Benveniste H. Microscopic Fluorescence Studies on Brain Intracellular Ca2+ Responses to Ischemia with and without Ca2+- Channel Blockade 2006, tui62. DOI: 10.1364/bio.2006.tui62.
  • A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopyMa Y, Hof P, Grant S, Blackband S, Bennett R, Slatest L, McGuigan M, Benveniste H. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy Neuroscience 2005, 135: 1203-1215. PMID: 16165303, DOI: 10.1016/j.neuroscience.2005.07.014.
  • Activation-Blood Flow Coupling During Direct Somatosensory Cortical Stimulation in Living Rat BrainLuo Z, Benveniste H, Yu M, Du C. Activation-Blood Flow Coupling During Direct Somatosensory Cortical Stimulation in Living Rat Brain 2005, 664-666. DOI: 10.1109/cne.2005.1419712.
  • A new fluorometric and optical approach for tracking of intracellular calcium, blood volume and oxygenation changes in the rat brain in vivoDu C, Izrailtyan I, Benveniste H. A new fluorometric and optical approach for tracking of intracellular calcium, blood volume and oxygenation changes in the rat brain in vivo 2004, fc6. DOI: 10.1364/bio.2004.fc6.
  • Anatomical Studies in the Rodent Brain and Spinal CordBenveniste H, Mareci T, Blackband S. Anatomical Studies in the Rodent Brain and Spinal Cord 2002, 232-256. DOI: 10.1201/9781420042153.ch7.
  • High Resolution MR Microimaging of Neuronal Tissue at 17.6 TGrant S, Benveniste H, Blackband S. High Resolution MR Microimaging of Neuronal Tissue at 17.6 T 2002, 2: 1209-1210. DOI: 10.1109/iembs.2002.1106352.
  • Progress in high field MRI at the University of FloridaBeck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida Magnetic Resonance Materials In Physics, Biology And Medicine 2002, 13: 152-157. DOI: 10.1016/s1352-8661(01)00140-5.
  • Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI StudyMcDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.
  • Progress in high field MRI at the University of FloridaBeck B, Plant D, Grant S, Thelwall P, Silver X, Mareci T, Benveniste H, Smith M, Collins C, Crozier S, Blackband S. Progress in high field MRI at the University of Florida Magnetic Resonance Materials In Physics, Biology And Medicine 2001, 13: 152-157. PMID: 11755090, PMCID: PMC3363288, DOI: 10.1007/bf02678590.
  • Magnetic Resonance Microscopy of the C57BL Mouse BrainBenveniste H, Kim K, Zhang L, Johnson G. Magnetic Resonance Microscopy of the C57BL Mouse Brain NeuroImage 2000, 11: 601-611. PMID: 10860789, DOI: 10.1006/nimg.2000.0567.
  • In vivo magnetic resonance imaging of transgene expressionWeissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E, Basilion J. In vivo magnetic resonance imaging of transgene expression Nature Medicine 2000, 6: 351-354. PMID: 10700241, DOI: 10.1038/73219.
  • Reply to Dr. Koscielniak-NielsenKlein S, Benveniste H. Reply to Dr. Koscielniak-Nielsen Regional Anesthesia & Pain Medicine 2000, 25: 104. DOI: 10.1097/00115550-200001000-00022.
  • Reply to Dr. Koscielniak-NielsenKlein S, Benveniste H. Reply to Dr. Koscielniak-Nielsen Regional Anesthesia & Pain Medicine 2000, 25: 104. DOI: 10.1016/s1098-7339(00)80023-1.
  • Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.
  • Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopyBenveniste H, Einstein G, Kim K, Hulette C, Johnson G. Detection of neuritic plaques in Alzheimer’s disease by magnetic resonance microscopy Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14079-14084. PMID: 10570201, PMCID: PMC24193, DOI: 10.1073/pnas.96.24.14079.
  • In Vivo Diffusion-Weighted Magnetic Resonance Microscopy of Rat Spinal CordBenveniste H, Qui H, Hedlund L, Hüttemeier P, Steele S, Johnson A. In Vivo Diffusion-Weighted Magnetic Resonance Microscopy of Rat Spinal Cord Regional Anesthesia & Pain Medicine 1999, 24: 311-318. DOI: 10.1097/00115550-199924040-00006.
  • In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaineBenveniste H, Qui H, Hedlund L, Hüttemeier P, Steele S, Johnson G. In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine Regional Anesthesia & Pain Medicine 1999, 24: 311-318. PMID: 10445769, DOI: 10.1016/s1098-7339(99)90104-9.
  • Three-dimensional magnetic resonance imaging of thoracic and lumbar paravertebral space in human cadaversMacLeod D, Martin G, D'Ercole F, Richardson W, Benveniste H. Three-dimensional magnetic resonance imaging of thoracic and lumbar paravertebral space in human cadavers Regional Anesthesia & Pain Medicine 1999, 24: 13. DOI: 10.1016/s1098-7339(99)90190-6.
  • THREE-DIMENSIONAL MAGNETIC RESONANCE IMAGING OF THORACIC AND LUMBAR PARAVERTEBRAL SPACE IN HUMAN CADAVERSMacLeod D, Martin G, D'Ercole F, Richardson W, Benveniste H. THREE-DIMENSIONAL MAGNETIC RESONANCE IMAGING OF THORACIC AND LUMBAR PARAVERTEBRAL SPACE IN HUMAN CADAVERS Regional Anesthesia & Pain Medicine 1999, 24: 13. DOI: 10.1097/00115550-199924031-00013.
  • Anxiety, vocalization, and agitation following peripheral nerve block with ropivacaineKlein S, Benveniste H. Anxiety, vocalization, and agitation following peripheral nerve block with ropivacaine Regional Anesthesia & Pain Medicine 1999, 24: 175-178. DOI: 10.1016/s1098-7339(99)90081-0.
  • Anxiety, Vocalization, and Agitation Following Peripheral Nerve Block With RopivacaineKlein S, Benveniste H. Anxiety, Vocalization, and Agitation Following Peripheral Nerve Block With Ropivacaine Regional Anesthesia & Pain Medicine 1999, 24: 175-178. PMID: 10204906, DOI: 10.1097/00115550-199924020-00014.
  • Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated AxonsScotland P, Zhou D, Benveniste H, Bennett V. Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons Journal Of Cell Biology 1998, 143: 1305-1315. PMID: 9832558, PMCID: PMC2133070, DOI: 10.1083/jcb.143.5.1305.
  • Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance MicroscopyBenveniste H, Qui H, Hedlund L, D'Ercole F, Johnson A. Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy Regional Anesthesia & Pain Medicine 1998, 23: 589-599. PMID: 9840856, DOI: 10.1097/00115550-199823060-00014.
  • Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopyBenveniste H, Qui H, Hedlund L, D'Ercole F, Johnson G. Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy Regional Anesthesia & Pain Medicine 1998, 23: 589-599. DOI: 10.1016/s1098-7339(98)90087-6.
  • High Performance Teams in the Operating RoomD'Ercole F, Hardman D, Benveniste H, Speer K, Gleason D, Greengrass R, Steele S, Klein S. High Performance Teams in the Operating Room Anesthesiology 1998, 89: 1346a. DOI: 10.1097/00000542-199809220-00018.
  • A teaching model for resident training in regional anesthesiaD'Ercole F, Bergh A, Klein S, Lineberger C, Greengrass R, Benveniste H, Steele S. A teaching model for resident training in regional anesthesia Regional Anesthesia & Pain Medicine 1998, 23: 112. DOI: 10.1097/00115550-199823031-00112.
  • In Vivo Magnetic Resonance Imaging of Rat Spinal Cord and Peripheral NervesBenveniste H, Hüttemeier P, Kim K, D'Ercole F, Steele S. In Vivo Magnetic Resonance Imaging of Rat Spinal Cord and Peripheral Nerves Regional Anesthesia & Pain Medicine 1998, 23: 97. DOI: 10.1097/00115550-199823031-00097.
  • Magnetic Resonance Microscopy of Alzheimer's disease: Senile Plaques - A whiter shade of pale?Benveniste H, Einstein G, Kim K, Johnson G. Magnetic Resonance Microscopy of Alzheimer's disease: Senile Plaques - A whiter shade of pale? NeuroImage 1998, 7: s519. DOI: 10.1016/s1053-8119(18)31352-1.
  • EXTRACELLULAR DOPAMINE AND GABA CONCENTRATIONS IN THE NIGRASTRIATAL SYSTEM AND THALAMUS OF RATS UNDER PROPOFOL ANESTHESIAShiraishi M, Kamiyama Y, Okamoto S, Huttemeier P, Benveniste H. EXTRACELLULAR DOPAMINE AND GABA CONCENTRATIONS IN THE NIGRASTRIATAL SYSTEM AND THALAMUS OF RATS UNDER PROPOFOL ANESTHESIA Anesthesia & Analgesia 1998, 86: 502s.. DOI: 10.1097/00000539-199802001-00500.
  • Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy studyQiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.
  • Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake ratsShiraishi M, Kamiyama Y, Hüttemeier P, Benveniste H. Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats Brain Research 1997, 759: 221-227. PMID: 9221940, DOI: 10.1016/s0006-8993(97)00258-8.
  • Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, bJOHNSON G, BENVENISTE H, ENGELHARDT R, QIU H, HEDLUND L. Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Functiona, b Annals Of The New York Academy Of Sciences 1997, 820: 139-148. PMID: 9237453, DOI: 10.1111/j.1749-6632.1997.tb46193.x.
  • A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance MicroscopyHall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.
  • Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic ratsHuttemeier P, Ritter E, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats American Journal Of Physiology 1993, 265: h767-h769. PMID: 8368378, DOI: 10.1152/ajpheart.1993.265.2.h767.
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemiaZhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.
  • Histology by magnetic resonance microscopy.Johnson G, Benveniste H, Black R, Hedlund L, Maronpot R, Smith B. Histology by magnetic resonance microscopy. Magnetic Resonance Quarterly 1993, 9: 1-30. PMID: 8512830.
  • Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemiaHuttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.
  • Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by DenervationDiemer N, Johansen F, Benveniste H, Bruhn T, Berg M, Valente E, Jørgensen M. Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation 1993, 94-101. DOI: 10.1007/978-3-7091-9266-5_14.
  • Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat BrainSimonson S, Zhang J, Canada A, Su Y, Benveniste H, Piantadosi C. Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain Cerebrovascular And Brain Metabolism Reviews 1993, 13: 125-134. PMID: 8417001, DOI: 10.1038/jcbfm.1993.15.
  • Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by DenervationDiemer N, Johansen F, Benveniste H, Bruhn T, Berg M, Valente E, Jørgensen M. Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation 1993, 57: 94-101. PMID: 8380675, DOI: 10.1007/978-3-7091-9266-5_14.
  • EFFECTS OF DANTROLENE ON HISTOLOGICAL OUTCOME IN RAT CAL HIPPOCAMPUS AFTER GLOBAL TRANSIENT CEREBRAL ISCHEMIAKAMIYAMA Y, SHIRAISHI M, BENVENISTE H, WATKINS W, HüTTEMEIER P. EFFECTS OF DANTROLENE ON HISTOLOGICAL OUTCOME IN RAT CAL HIPPOCAMPUS AFTER GLOBAL TRANSIENT CEREBRAL ISCHEMIA Anesthesiology 1992, 77: a781. DOI: 10.1097/00000542-199209001-00781.
  • Direct digitization of optical images using a photostimulable phosphor systemDobbins J, Chotas H, Benveniste H. Direct digitization of optical images using a photostimulable phosphor system Medical Physics 1992, 19: 1071-1080. PMID: 1518470, DOI: 10.1118/1.596917.
  • Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.
  • MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flowMaki J, Benveniste H, Macfall J, Piantadosi C, Johnson G. MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow Journal Of Magnetic Resonance Imaging 1991, 1: 673-681. PMID: 1823172, DOI: 10.1002/jmri.1880010609.
  • Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucoseHilgier W, Benveniste H, Diemer N, Albrecht J. Decreased glucose utilization in discrete brain regions of rat in thioacetamide‐induced hepatic encephalopathy as measured with [3H]‐deoxyglucose Acta Neurologica Scandinavica 1991, 83: 353-355. PMID: 1887755, DOI: 10.1111/j.1600-0404.1991.tb03961.x.
  • Diffusion/microcirculation MRI in the rat brainMacfall J, Maki J, Johnson G, Hedlund L, Benveniste H, Copher G. Diffusion/microcirculation MRI in the rat brain Magnetic Resonance In Medicine 1991, 19: 305-310. PMID: 1908936, DOI: 10.1002/mrm.1910190219.
  • Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.
  • Chapter 4 Practical aspects of using microdialysis for determination of brain interstitial concentrationsBenveniste H, Hansen A. Chapter 4 Practical aspects of using microdialysis for determination of brain interstitial concentrations 1991, 7: 81-100. DOI: 10.1016/b978-0-444-81194-3.50009-5.
  • Maximization of contrast‐to‐noise ratio to distinguish diffusion and microcirculatory flowMaki J, Benveniste H, MacFall J, Johnson G. Maximization of contrast‐to‐noise ratio to distinguish diffusion and microcirculatory flow Journal Of Magnetic Resonance Imaging 1991, 1: 39-46. PMID: 1802129, DOI: 10.1002/jmri.1880010105.
  • The excitotoxin hypothesis in relation to cerebral ischemia.Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.
  • A715 Microdialysis measurements of arachidonic acid metabolites in rat CA1 hippocampus during transient cerebral ischemiaBenveniste H, Huttemeier P, Brothers M, Watkins W. A715 Microdialysis measurements of arachidonic acid metabolites in rat CA1 hippocampus during transient cerebral ischemia Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00713.
  • Microdialysis—Theory and applicationBenveniste H, Hüttemeier P. Microdialysis—Theory and application Progress In Neurobiology 1990, 35: 195-215. PMID: 2236577, DOI: 10.1016/0301-0082(90)90027-e.
  • MR Diffusion Measurements In Stroke Models In Rat BrainsMacFall J, Benveniste H, Maki J, Johnson G, Hedlund L, Copher G. MR Diffusion Measurements In Stroke Models In Rat Brains 1990, 67-68. DOI: 10.1109/iembs.1990.690951.
  • Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3Benveniste H, Jørgensen M, Sandberg M, Christensen T, Hagberg H, Diemer N. Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3 Cerebrovascular And Brain Metabolism Reviews 1989, 9: 629-639. PMID: 2570785, DOI: 10.1038/jcbfm.1989.90.
  • Determination of Brain Interstitial Concentrations by MicrodialysisBenveniste H, Hansen A, Ottosen N. Determination of Brain Interstitial Concentrations by Microdialysis Journal Of Neurochemistry 1989, 52: 1741-1750. PMID: 2723633, DOI: 10.1111/j.1471-4159.1989.tb07252.x.
  • Brain MicrodialysisBenveniste H. Brain Microdialysis Journal Of Neurochemistry 1989, 52: 1667-1679. PMID: 2656913, DOI: 10.1111/j.1471-4159.1989.tb07243.x.
  • Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor BlockersBenveniste H, Hüttemeier P, Johansen F, Diemer N. Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers 1989, 266-273. DOI: 10.1007/978-3-642-85863-5_34.
  • Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemiaBenveniste H, Jørgensen M, Diemer N, Hansen A. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia Acta Neurologica Scandinavica 1988, 78: 529-536. PMID: 2906199, DOI: 10.1111/j.1600-0404.1988.tb03697.x.
  • Early Postischemic 45Ca Accumulation in Rat Dentate HilusBenveniste H, Diemer N. Early Postischemic 45Ca Accumulation in Rat Dentate Hilus Cerebrovascular And Brain Metabolism Reviews 1988, 8: 713-719. PMID: 3417798, DOI: 10.1038/jcbfm.1988.118.
  • Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-ReceptorBenveniste H, Diemer N. Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor 1988, 35: 377-377. DOI: 10.1007/978-1-4684-5562-5_40.
  • Cellular reactions to implantation of a microdialysis tube in the rat hippocampusBenveniste H, Diemer N. Cellular reactions to implantation of a microdialysis tube in the rat hippocampus Acta Neuropathologica 1987, 74: 234-238. PMID: 3673515, DOI: 10.1007/bf00688186.
  • Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the RatBenveniste H, Drejer J, Schousboe A, Diemer N. Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat Journal Of Neurochemistry 1987, 49: 729-734. PMID: 3612121, DOI: 10.1111/j.1471-4159.1987.tb00954.x.
  • Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In VitroDrejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.
  • Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisBenveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.
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