Skip to Main Content
Directory of Faculty Research Interests
YSM Home

INFORMATION FOR

DownloadHi-Res Photo

Christopher Pittenger, MD, PhD

he/him/his
Elizabeth Mears and House Jameson Professor of Psychiatry; Deputy Chair for Translational Research, Psychiatry; Director, Clinical Neuroscience Research Unit, Psychiatry; Director, Yale Program for Psychedelic Science, Psychiatry; Director, Yale Center for Brain and Mind Health, Yale School of Medicine; Director, Yale OCD Research Clinic, Psychiatry; Director, Neuroscience Research Training Program, Yale Department of Psychiatry

Contact Information

Christopher Pittenger, MD, PhD

Office Location

Mailing Address

  • Psychiatry

    34 Park Street

    New Haven, CT 06519

    United States

PittLab

Related Links

Yale Medicine

Patient Care

Are you a patient?Please visit the Yale Medicine website for information about the services we offer and making an appointment.View Doctor Profile

Research Summary

My research is aimed towards a better understanding of a particular network of brain structures, called the basal ganglia, and the consequences of dysfunction of this network in various neuropsychiatric diseases. The basal ganglia are involved in motor control, in the formation of behavioral patterns and habits, and in the regulation of reward. Abnormalities in this circuit are implicated in a variety of conditions characterized by maladaptive, inflexible behaviors - habits gone bad. These include obsessive-compulsive disorder, Tourette syndrome, and drug addiction.

Our research in the laboratory has two strands. First, we seek to better understand the mechanisms of normal basal ganglia-dependent habit-like learning, by manipulating this circuit in mice. Second, we seek to better understand how perturbation of the basal ganglia system can lead to symptoms of psychiatric disease. We do this by recapitulating hypothesized causes of diseases such as Tourette syndrome, OCD, and autism, again in mice, and testing the behavioral and neurophysiological consequences.

I also direct the Yale OCD Research Clinic, where our research aims towards the better understanding of the biology of obsessive compulsive disorder and the development of new treatments. We have a number of active research programs. We are investigating abnormalities in the neurotransmitter glutamate in OCD and whether glutamate modulating medications can be of therapeutic benefit. We are probing the network connectivity of the brain in OCD and Tourette syndrome using recent advances in fMRI imaging. We are exploring the phenomenological heterogeneity of OCD, seeking clues to how we might better personalize effective treatments. We are also developing innovative neurofeedback techniques, in which patients actually learn to control the activity of key brain regions, in an effort to develop a new type of nonpharmacological treatment. And we are using noninvasive brain stimulation to modulate the function of cortico-basal ganglia circuits and enhance the mechanisms of psychotherapy.

Extensive Research Description

STUDIES OF BASAL GANGLIA FUNCTION IN MICE. The basal ganglia, consisting of the striatum (caudate-putamen) and related subcortical structures, have historically been considered to have primarily motor functions; but it has become increasingly clear that they are also involved in a variety of cognitive and affective processes. Disruption of normal basal ganglia function is seen in a variety of neuropsychiatric conditions, such as obsessive-compulsive disorder, Tourette syndrome, and drug addiction.

The striatum has been divided into distinct functional regions, though both the anatomical subdivisions and the functions with which they are associated remain approximate and subject to debate. The ventral striatum, consisting of the nucleus accumbens and related structures, has a well-documented role in reward and reward-driven learning, and has been extensively researched in the context of drug addiction. The dorsal striatum (caudate and putamen, in primates) is thought to have a role in the formation of motor and cognitive patterns and in forms of implicit learning, including the formation of habits.

The Pittenger laboratory is focused on better understanding the mechanisms of dorsal striatum-dependent habit-like learning, and of the consequences of its perturbation in various neuropsychiatric conditions. We conduct our researches primarily in mice, which allows us to take advantage of sophisticated reverse genetic techniques to perturb the striatal circuitry in molecularly precise ways and to target specific striatal subregions and neuronal subtypes.

MODELING PSYCHIATRIC DISEASE. We are applying this technology to model neuropsychiatric conditions affecting the striatum, especially Tourette syndrome. This represents a third focus of the laboratory. Modeling psychiatric disease in animals has proven enormously challenging, because etiology is often obscure and symptomatology is often difficult to translate to non-verbal species. We believe that the development of valid models hinges on a sufficient degree of understanding of pathophysiology to ensure validity when translating to animals.

Fortunately, studies at Yale and elsewhere are beginning to produce such understanding in the case of Tourette syndrome. We are using genetic methods to produce putative models of Tourette syndrome based both on post-mortem findings and on genetic insights . These animals are then being tested in a variety of behavioral assays to assess their recapitulation of Tourette syndrome phenomenology, explore secondary and tertiary consequences of the initial manipulations, and investigate the response to both established and novel medications.

A FOCUS ON TRANSLATIONAL RESEARCH: NEW MEDICATIONS FOR OBSESSIVE-COMPULSIVE DISORDER (OCD). The final focus of the Pittenger laboratory is also translational. Dr. Pittenger is Director of the Yale OCD Research Clinic, where he has found glutamate-modulating medications to be of potential benefit in the treatment of patients with obsessive-compulsive disorder (a condition in which basal ganglia dysfunction is implicated). We are examining the behavioral and molecular effects of such glutamate-modulating drugs in animals, to better understand their role in patients with this and related conditions. As new animal models of disorders of the basal ganglia, like OCD, become available, we hope to use this translational approach to advance our understanding both of the normal role of the basal ganglia in behavior and its perturbation in disease, and to develop new generations of therapeutics for the psychiatric population.

Coauthors

Research Interests

Basal Ganglia Diseases; Tourette Syndrome; Learning; Molecular Biology; Neuroanatomy; Neurobiology; Neurophysiology; Neurosciences; Obsessive-Compulsive Disorder; Phobic Disorders; Psychopharmacology; Trichotillomania

Selected Publications

  • Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case reportJankovsky A, Zaboski B, Pittenger C. Pharmacotherapy for comorbid antisocial personality and obsessive-compulsive disorder: A case report Psychiatry Research Case Reports 2023, 2: 100139. DOI: 10.1016/j.psycr.2023.100139.
  • Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders.Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023 PMID: 37306960, DOI: 10.1093/schbul/sbad073.
  • Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiologyCadeddu R, Van Zandt M, Santovito L, Odeh K, Anderson C, Flanagan D, Nordkild P, Pinna G, Pittenger C, Bortolato M. Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology Neuropsychopharmacology 2023, 1-12. PMID: 37198434, DOI: 10.1038/s41386-023-01603-6.
  • The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortiumBruin W, Abe Y, Alonso P, Anticevic A, Backhausen L, Balachander S, Bargallo N, Batistuzzo M, Benedetti F, Bertolin Triquell S, Brem S, Calesella F, Couto B, Denys D, Echevarria M, Eng G, Ferreira S, Feusner J, Grazioplene R, Gruner P, Guo J, Hagen K, Hansen B, Hirano Y, Hoexter M, Jahanshad N, Jaspers-Fayer F, Kasprzak S, Kim M, Koch K, Bin Kwak Y, Kwon J, Lazaro L, Li C, Lochner C, Marsh R, Martínez-Zalacaín I, Menchon J, Moreira P, Morgado P, Nakagawa A, Nakao T, Narayanaswamy J, Nurmi E, Zorrilla J, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy J, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson B, Soriano-Mas C, Sousa N, Spalletta G, Stern E, Evelyn Stewart S, Szeszko P, Tang J, Thomopoulos S, Thorsen A, Tokiko Y, Tomiyama H, Vai B, Veer I, Venkatasubramanian G, Vetter N, Vriend C, Walitza S, Waller L, Wang Z, Watanabe A, Wolff N, Yun J, Zhao Q, van Leeuwen W, van Marle H, van de Mortel L, van der Straten A, van der Werf Y, Thompson P, Stein D, van den Heuvel O, van Wingen G. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium Molecular Psychiatry 2023, 1-13. PMID: 37131072, DOI: 10.1038/s41380-023-02077-0.
  • 390. Altered Confidence Adaptation During Set-Shifting in OCDLoosen A, Zaboski B, Pushkarskaya H, Pittenger C, Hauser T. 390. Altered Confidence Adaptation During Set-Shifting in OCD Biological Psychiatry 2023, 93: s252. DOI: 10.1016/j.biopsych.2023.02.630.
  • 332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in MiceJefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Kaye A, Pittenger C, Kwan A. 332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice Biological Psychiatry 2023, 93: s228. DOI: 10.1016/j.biopsych.2023.02.572.
  • 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive DisorderSarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
  • Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in MiceKaye A, Kwan A, Pittenger C, Yu A, Yang J. Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice Biological Psychiatry 2023, 93: s57. DOI: 10.1016/j.biopsych.2023.02.156.
  • 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life StressJiang C, Pittenger C. 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress Biological Psychiatry 2023, 93: s234. DOI: 10.1016/j.biopsych.2023.02.588.
  • Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trialChing T, Grazioplene R, Bohner C, Kichuk S, DePalmer G, D’Amico E, Eilbott J, Jankovsky A, Burke M, Hokanson J, Martins B, Witherow C, Patel P, Amoroso L, Schaer H, Pittenger C, Kelmendi B. Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial Frontiers In Psychiatry 2023, 14: 1178529. PMID: 37181888, PMCID: PMC10166878, DOI: 10.3389/fpsyt.2023.1178529.
  • 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in miceJefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Woodburn S, Wehrle P, Sprouse J, Sherwood A, Kaye A, Pittenger C, Kwan A. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice Neuropsychopharmacology 2023, 1-10. PMID: 37015972, DOI: 10.1038/s41386-023-01572-w.
  • The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviorsXu J, Pittenger C. The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors Journal Of Biological Chemistry 2023, 299: 104583. PMID: 36871761, PMCID: PMC10139999, DOI: 10.1016/j.jbc.2023.104583.
  • Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric SyndromeVreeland A, Thienemann M, Cunningham M, Muscal E, Pittenger C, Frankovich J. Neuroinflammation in Obsessive-Compulsive Disorder Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome Psychiatric Clinics Of North America 2023, 46: 69-88. PMID: 36740356, DOI: 10.1016/j.psc.2022.11.004.
  • Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficitsRapanelli M, Wang W, Hurley E, Feltri M, Pittenger C, Frick L, Yan Z. Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits Translational Psychiatry 2023, 13: 22. PMID: 36693858, PMCID: PMC9873627, DOI: 10.1038/s41398-023-02306-8.
  • Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activityWarner-Schmidt J, Pittenger C, Stogniew M, Mandell B, Olmstead S, Kelmendi B. Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity Frontiers In Psychiatry 2023, 13: 1041277. PMID: 36704743, PMCID: PMC9873307, DOI: 10.3389/fpsyt.2022.1041277.
  • The Pharmacological Treatment of Obsessive-Compulsive DisorderPittenger C. The Pharmacological Treatment of Obsessive-Compulsive Disorder Psychiatric Clinics Of North America 2023, 46: 107-119. PMID: 36740347, DOI: 10.1016/j.psc.2022.11.005.
  • Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case reportKelmendi B, Kichuk S, DePalmer G, Maloney G, Ching T, Belser A, Pittenger C. Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report Heliyon 2022, 8: e12135. PMID: 36536916, PMCID: PMC9758406, DOI: 10.1016/j.heliyon.2022.e12135.
  • White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiologyJindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.
  • White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiologyJindachomthong K, Yang C, Huang Y, Coman D, Rapanelli M, Hyder F, Dougherty J, Frick L, Pittenger C. White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology Frontiers In Molecular Neuroscience 2022, 15: 1037481. PMID: 36504678, PMCID: PMC9731796, DOI: 10.3389/fnmol.2022.1037481.
  • 19.1 Renaissance in Psychedelic ResearchPittenger C. 19.1 Renaissance in Psychedelic Research Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 61: s305. DOI: 10.1016/j.jaac.2022.07.662.
  • Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case StudyMaloney G, Kelmendi B, Pittenger C. Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study Clinical Case Studies 2022, 22: 174-191. DOI: 10.1177/15346501221123797.
  • P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant PathologyJiang C, Pittenger C. P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology Biological Psychiatry 2022, 91: s272. DOI: 10.1016/j.biopsych.2022.02.692.
  • Studying the pathophysiology of tic disorders in animal modelsPittenger C. Studying the pathophysiology of tic disorders in animal models 2022, 4: 39-61. DOI: 10.1016/bs.irmvd.2022.06.001.
  • The Roles of Endogenous Opioid System in the Antidepressant Actions of KetamineJiang C, DiLeone R, Pittenger C, Duman R. The Roles of Endogenous Opioid System in the Antidepressant Actions of Ketamine Biological Psychiatry 2021, 89: s385. DOI: 10.1016/j.biopsych.2021.02.956.
  • Obsessive Compulsive Symptom Dimensions are Linked to Altered White Matter Microstructure in a Community Sample of AdolescentsGrazioplene R, Hampson M, Anticevic A, Pittenger C. Obsessive Compulsive Symptom Dimensions are Linked to Altered White Matter Microstructure in a Community Sample of Adolescents Biological Psychiatry 2021, 89: s16-s17. DOI: 10.1016/j.biopsych.2021.02.061.
  • Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their ActivityXu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity American Journal Of Psychiatry 2020, 178: 48-64. PMID: 32539528, PMCID: PMC8573771, DOI: 10.1176/appi.ajp.2020.19070698.
  • Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor BehaviorEmmons E, Xu J, Pittenger C. Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior Biological Psychiatry 2020, 87: s295. DOI: 10.1016/j.biopsych.2020.02.760.
  • Excessive acquisition of information during simple judgments in individuals with hoarding disorderPushkarskaya H, Stern E, Tolin D, Pittenger C. Excessive acquisition of information during simple judgments in individuals with hoarding disorder Journal Of Obsessive-Compulsive And Related Disorders 2020, 24: 100505. DOI: 10.1016/j.jocrd.2020.100505.
  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric DisordersConsortium C, Lee P, Anttila V, Won H, Feng Y, Rosenthal J, Zhu Z, Tucker-Drob E, Nivard M, Grotzinger A, Posthuma D, Wang M, Yu D, Stahl E, Walters R, Anney R, Duncan L, Ge T, Adolfsson R, Banaschewski T, Belangero S, Cook E, Coppola G, Derks E, Hoekstra P, Kaprio J, Keski-Rahkonen A, Kirov G, Kranzler H, Luykx J, Rohde L, Zai C, Agerbo E, Arranz M, Asherson P, Bækvad-Hansen M, Baldursson G, Bellgrove M, Belliveau R, Buitelaar J, Burton C, Bybjerg-Grauholm J, Casas M, Cerrato F, Chambert K, Churchhouse C, Cormand B, Crosbie J, Dalsgaard S, Demontis D, Doyle A, Dumont A, Elia J, Grove J, Gudmundsson O, Haavik J, Hakonarson H, Hansen C, Hartman C, Hawi Z, Hervás A, Hougaard D, Howrigan D, Huang H, Kuntsi J, Langley K, Lesch K, Leung P, Loo S, Martin J, Martin A, McGough J, Medland S, Moran J, Mors O, Mortensen P, Oades R, Palmer D, Pedersen C, Pedersen M, Peters T, Poterba T, Poulsen J, Ramos-Quiroga J, Reif A, Ribasés M, Rothenberger A, Rovira P, Sánchez-Mora C, Satterstrom F, Schachar R, Artigas M, Steinberg S, Stefansson H, Turley P, Walters G, Team 2, Werge T, Zayats T, Arking D, Bettella F, Buxbaum J, Christensen J, Collins R, Coon H, De Rubeis S, Delorme R, Grice D, Hansen T, Holmans P, Hope S, Hultman C, Klei L, Ladd-Acosta C, Magnusson P, Nærland T, Nyegaard M, Pinto D, Qvist P, Rehnström K, Reichenberg A, Reichert J, Roeder K, Rouleau G, Saemundsen E, Sanders S, Sandin S, St Pourcain B, Stefansson K, Sutcliffe J, Talkowski M, Weiss L, Willsey A, Agartz I, Akil H, Albani D, Alda M, Als T, Anjorin A, Backlund L, Bass N, Bauer M, Baune B, Bellivier F, Bergen S, Berrettini W, Biernacka J, Blackwood D, Bøen E, Budde M, Bunney W, Burmeister M, Byerley W, Byrne E, Cichon S, Clarke T, Coleman J, Craddock N, Curtis D, Czerski P, Dale A, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Elvsåshagen T, Etain B, Fischer S, Forstner A, Forty L, Frank J, Frye M, Fullerton J, Gade K, Gaspar H, Gershon E, Gill M, Goes F, Gordon S, Gordon-Smith K, Green M, Greenwood T, Grigoroiu-Serbanescu M, Guzman-Parra J, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hoffmann P, Holland D, Jamain S, Jones I, Jones L, Kandaswamy R, Kelsoe J, Kennedy J, Joachim O, Kittel-Schneider S, Kogevinas M, Koller A, Lavebratt C, Lewis C, Li Q, Lissowska J, Loohuis L, Lucae S, Maaser A, Malt U, Martin N, Martinsson L, McElroy S, McMahon F, McQuillin A, Melle I, Metspalu A, Millischer V, Mitchell P, Montgomery G, Morken G, Morris D, Müller-Myhsok B, Mullins N, Myers R, Nievergelt C, Nordentoft M, Adolfsson A, Nöthen M, Ophoff R, Owen M, Paciga S, Pato C, Pato M, Perlis R, Perry A, Potash J, Reinbold C, Rietschel M, Rivera M, Roberson M, Schalling M, Schofield P, Schulze T, Scott L, Serretti A, Sigurdsson E, Smeland O, Stordal E, Streit F, Strohmaier J, Thorgeirsson T, Treutlein J, Turecki G, Vaaler A, Vieta E, Vincent J, Wang Y, Witt S, Zandi P, Adan R, Alfredsson L, Ando T, Aschauer H, Baker J, Bencko V, Bergen A, Birgegård A, Perica V, Brandt H, Burghardt R, Carlberg L, Cassina M, Clementi M, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, Degortes D, DeSocio J, Dick D, Dina C, Docampo E, Egberts K, Ehrlich S, Espeseth T, Fernández-Aranda F, Fichter M, Foretova L, Forzan M, Gambaro G, Giegling I, Gonidakis F, Gorwood P, Mayora M, Guo Y, Halmi K, Hatzikotoulas K, Hebebrand J, Helder S, Herpertz-Dahlmann B, Herzog W, Hinney A, Imgart H, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kaminská D, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy M, Kim Y, Klareskog L, Klump K, Knudsen G, Landén M, Le Hellard S, Levitan R, Li D, Lichtenstein P, Maj M, Marsal S, McDevitt S, Mitchell J, Monteleone P, Monteleone A, Munn-Chernoff M, Nacmias B, Navratilova M, O’Toole J, Padyukov L, Pantel J, Papezova H, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Roberts M, Rujescu D, Rybakowski F, Scherag A, Schmidt U, Seitz J, Slachtova L, Landt M, Slopien A, Sorbi S, Southam L, Strober M, Tortorella A, Tozzi F, Treasure J, Tziouvas K, van Elburg A, Wade T, Wagner G, Walton E, Watson H, Wichmann H, Woodside D, Zeggini E, Zerwas S, Zipfel S, Adams M, Andlauer T, Berger K, Binder E, Boomsma D, Castelao E, Colodro-Conde L, Direk N, Docherty A, Domenici E, Domschke K, Dunn E, Foo J, de. Geus E, Grabe H, Hamilton S, Horn C, Hottenga J, Howard D, Ising M, Kloiber S, Levinson D, Lewis G, Magnusson P, Mbarek H, Middeldorp C, Mostafavi S, Nyholt D, Penninx B, Peterson R, Pistis G, Porteous D, Preisig M, Quiroz J, Schaefer C, Schulte E, Shi J, Smith D, Thomson P, Tiemeier H, Uher R, van der Auwera S, Weissman M, Alexander M, Begemann M, Bramon E, Buccola N, Cairns M, Campion D, Carr V, Cloninger C, Cohen D, Collier D, Corvin A, DeLisi L, Donohoe G, Dudbridge F, Duan J, Freedman R, Gejman P, Golimbet V, Godard S, Ehrenreich H, Hartmann A, Henskens F, Ikeda M, Iwata N, Jablensky A, Joa I, Jönsson E, Kelly B, Knight J, Konte B, Laurent-Levinson C, Lee J, Lencz T, Lerer B, Loughland C, Malhotra A, Mallet J, McDonald C, Mitjans M, Mowry B, Murphy K, Murray R, O’Neill F, Oh S, Palotie A, Pantelis C, Pulver A, Consortium P, Petryshen T, Quested D, Riley B, Sanders A, Schall U, Schwab S, Scott R, Sham P, Silverman J, Sim K, Steixner A, Tooney P, van Os J, Vawter P, Walsh D, Weiser M, Wildenauer D, Williams N, Wormley B, Consortium W, Zhang F, Androutsos C, Arnold P, Barr C, Barta C, Bey K, Bienvenu O, Black D, Brown L, Budman C, Cath D, Cheon K, Ciullo V, Coffey B, Cusi D, Davis L, Denys D, Depienne C, Dietrich A, Eapen V, Falkai P, Fernandez T, Garcia-Delgar B, Geller D, Gilbert D, Grados M, Greenberg E, Grünblatt E, Hagstrøm J, Hanna G, Hartmann A, Hedderly T, Heiman G, Heyman I, Hong H, Huang A, Huyser C, Ibanez-Gomez L, Khramtsova E, Kim Y, Kim Y, King R, Koh Y, Konstantinidis A, Kook S, Kuperman S, Leventhal B, Lochner C, Ludolph A, Madruga-Garrido M, Malaty I, Maras A, McCracken J, Meijer I, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy T, Naarden A, Nagy P, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Okun M, Paschou P, Piras F, Piras F, Pittenger C, Plessen K, Richter M, Rizzo R, Robertson M, Roessner V, Ruhrmann S, Samuels J, Sandor P, Schlögelhofer M, Shin E, Singer H, Song D, Song J, Spalletta G, Stein D, Stewart S, Storch E, Stranger B, Stuhrmann M, Tarnok Z, Tischfield J, Tübing J, Visscher F, Vulink N, Wagner M, Walitza S, Wanderer S, Woods M, Worbe Y, Zai G, Zinner S, Sullivan P, Franke B, Daly M, Bulik C, McIntosh A, O’Donovan M, Zheutlin A, Andreassen O, Børglum A, Breen G, Edenberg H, Fanous A, Faraone S, Gelernter J, Mathews C, Mattheisen M, Mitchell K, Neale M, Nurnberger J, Ripke S, Santangelo S, Scharf J, Stein M, Thornton L, Walters J, Wray N, Geschwind D, Neale B, Kendler K, Smoller J. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders Cell 2019, 179: 1469-1482.e11. PMID: 31835028, PMCID: PMC7077032, DOI: 10.1016/j.cell.2019.11.020.
  • F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD)Gruner P, Koller W, Anticevic A, Pittenger C. F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD) Biological Psychiatry 2019, 85: s219. DOI: 10.1016/j.biopsych.2019.03.553.
  • Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling StudyMacLaren Kelly J, Kertz S, Simpson R, Bloch M, Pittenger C. Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study Journal Of Technology In Behavioral Science 2018, 4: 297-302. DOI: 10.1007/s41347-018-0078-y.
  • Analysis of shared heritability in common disorders of the brainConsortium T, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Schott J, Rossor M, Lupton M, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis J, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee S, De Jager P, Geschwind D, Riemenschneider M, Riedel-Heller S, Rotter J, Ransmayr G, Hyman B, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh K, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt G, Freilinger T, Ran C, Gordon S, Borck G, Adams H, Lehtimäki T, Wedenoja J, Buring J, Schürks M, Hrafnsdottir M, Hottenga J, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin N, Montgomery G, Kurki M, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari M, Belin A, van den Maagdenberg A, Zwart J, Boomsma D, Eriksson N, Olesen J, Chasman D, Nyholt D, Anney R, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono R, Catarino C, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro T, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz W, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller R, Molloy A, Ng P, Oliver K, Privitera M, Radtke R, Ruppert A, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya S, Smith P, Sperling M, Striano P, Surges R, Thomas G, Visscher F, Whelan C, Zara F, Heinzen E, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris H, Sharma M, Ryten M, Mok K, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen W, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Perica V, Thornton L, Huckins L, Rayner N, Lewis C, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson J, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker J, O’Toole J, Trace S, Davis O, Helder S, Ehrlich S, Herpertz-Dahlmann B, Danner U, van Elburg A, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick D, Ripatti S, Andreassen O, Espeseth T, Lundervold A, Steen V, Pinto D, Scherer S, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi K, Mitchell J, Strober M, Bergen A, Kaye W, Szatkiewicz J, Cormand B, Ramos-Quiroga J, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz M, Haavik J, Zayats T, Johansson S, Williams N, Elia J, Dempfle A, Rothenberger A, Kuntsi J, Oades R, Banaschewski T, Franke B, Buitelaar J, Vasquez A, Doyle A, Reif A, Lesch K, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt S, Dalsgaard S, Børglum A, Waldman I, Wilmot B, Molly N, Bau C, Crosbie J, Schachar R, Loo S, McGough J, Grevet E, Medland S, Robinson E, Weiss L, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck S, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca D, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze T, Thompson R, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen S, Schalling M, Jamain S, Maaser A, Fischer S, Reinbold C, Fullerton J, Grigoroiu-Serbanescu M, Guzman-Parra J, Mayoral F, Schofield P, Cichon S, Mühleisen T, Degenhardt F, Schumacher J, Bauer M, Mitchell P, Gershon E, Rice J, Potash J, Zandi P, Craddock N, Ferrier I, Alda M, Rouleau G, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski P, Edenberg H, Cruceanu C, Jones I, Posthuma D, Andlauer T, Forstner A, Streit F, Baune B, Air T, Sinnamon G, Wray N, MacIntyre D, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp C, Hickie I, Pergadia M, Mehta D, Smit J, Jansen R, de Geus E, Dunn E, Li Q, Nauck M, Schoevers R, Beekman A, Knowles J, Viktorin A, Arnold P, Barr C, Bedoya-Berrio G, Bienvenu O, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks E, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna G, Hartmann A, Hirschtritt M, Hoekstra P, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon G, Macciardi F, Madruga-Garrido M, Malaty I, Maras A, McGrath L, Miguel E, Mir P, Nestadt G, Nicolini H, Okun M, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos E, Reus V, Richter M, Riddle M, Robertson M, Roessner V, Rosário M, Samuels J, Sandor P, Stein D, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland J, Wolanczyk T, Worbe Y, Zai G, Goes F, McLaughlin N, Nestadt P, Grabe H, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong S, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy K, Murray R, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders A, Schall U, Schwab S, Sim K, So H, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman P, Henskens F, Mattingsdal M, Oh S, Scott R, Webb B, Breen G, Churchhouse C, Bulik C, Daly M, Dichgans M, Faraone S, Guerreiro R, Holmans P, Kendler K, Koeleman B, Mathews C, Price A, Scharf J, Sklar P, Williams J, Wood N, Cotsapas C, Palotie A, Smoller J, Sullivan P, Rosand J, Corvin A, Neale B. Analysis of shared heritability in common disorders of the brain Science 2018, 360 PMID: 29930110, PMCID: PMC6097237, DOI: 10.1126/science.aap8757.
  • T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward TaskAdkinson B, Kolobaric A, Flynn M, Dowiak C, Schleifer C, Santamauro N, Beech C, Lobe J, Zalevsky O, Cho Y, Pittenger C, Anticevic A. T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task Biological Psychiatry 2018, 83: s135. DOI: 10.1016/j.biopsych.2018.02.354.
  • The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive DisorderAdams T, Kelmendi B, Brake C, Gruner P, Badour C, Pittenger C. The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder Chronic Stress 2018, 2: 2470547018758043. PMID: 29527593, PMCID: PMC5841259, DOI: 10.1177/2470547018758043.
  • Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working GroupBoedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.
  • Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al.Boedhoe P, Schmaal L, Mataix-Cols D, Jahanshad N, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Association and Causation in Brain Imaging in the Case of OCD: Response to McKay et al. American Journal Of Psychiatry 2017, 174: 597-599. PMID: 28565945, PMCID: PMC6546159, DOI: 10.1176/appi.ajp.2017.17010019r.
  • Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment.Pittenger, C. (editor). Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. New York: Oxford University Press
  • 37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDERPittenger C. 37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: s317. DOI: 10.1016/j.jaac.2016.07.338.
  • Meta-Analysis of the Symptom Structure of Obsessive-Compulsive DisorderBloch M, Landeros-Weisenberger A, Rosario M, Pittenger C, Leckman J. Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 232-243. DOI: 10.1176/appi.focus.130209.
  • Are There Biological Commonalities Among Different Psychiatric Disorders?Etkin A, Pittenger C. Are There Biological Commonalities Among Different Psychiatric Disorders? 2015, 243-257. DOI: 10.1002/9781118753378.ch15.
  • Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndromeXu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 893-898. PMID: 25561540, PMCID: PMC4311862, DOI: 10.1073/pnas.1419533112.
  • Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive DisorderPittenger C. Chapter 47 Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder 2015, 747-764. DOI: 10.1016/b978-0-12-405195-9.00047-0.
  • Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and MiceBaldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
  • Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and MiceBaldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice Neuron 2014, 81: 77-90. PMID: 24411733, PMCID: PMC3894588, DOI: 10.1016/j.neuron.2013.10.052.
  • Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive DisorderAnticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.
  • Tourette Syndrome and Tic DisordersWilliams K, Bloch M, State M, Pittenger C. Tourette Syndrome and Tic Disorders 2013, 1048-1060. DOI: 10.1093/med/9780199934959.003.0079.
  • Erratum: Genome-wide association study of obsessive-compulsive disorderStewart S, Yu D, Scharf J, Neale B, Fagerness J, Mathews C, Arnold P, Evans P, Gamazon E, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-Vander Weele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Erratum: Genome-wide association study of obsessive-compulsive disorder Molecular Psychiatry 2013, 18: 843-843. DOI: 10.1038/mp.2013.15.
  • Genome-wide association study of obsessive-compulsive disorderStewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund C, Rauch S, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe H, Lennertz L, Wagner M, Bellodi L, Cavallini M, Richter M, Cook E, Kennedy J, Rosenberg D, Stein D, Hemmings S, Lochner C, Azzam A, Chavira D, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy D, Wendland J, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg H, Walitza S, Egberts K, Renner T, Miguel E, Cappi C, Hounie A, Conceição do Rosário M, Sampaio A, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato C, Pato M, Voyiaziakis E, Heutink P, Cath D, Posthuma D, Smit J, Samuels J, Bienvenu O, Cullen B, Fyer A, Grados M, Greenberg B, McCracken J, Riddle M, Wang Y, Coric V, Leckman J, Bloch M, Pittenger C, Eapen V, Black D, Ophoff R, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs J, Cookson M, Singleton A, Hardy J, Crenshaw A, Parkin M, Mirel D, Conti D, Purcell S, Nestadt G, Hanna G, Jenike M, Knowles J, Cox N, Pauls D. Genome-wide association study of obsessive-compulsive disorder Molecular Psychiatry 2012, 18: 788-798. PMID: 22889921, PMCID: PMC4218751, DOI: 10.1038/mp.2012.85.
  • Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive DisorderBloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder Biological Psychiatry 2012, 72: 964-970. PMID: 22784486, PMCID: PMC3667652, DOI: 10.1016/j.biopsych.2012.05.028.
  • Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination AnxietyHampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety Journal Of Visualized Experiments 2012 DOI: 10.3791/3535-v.
  • Chapter 22 Cyclic Nucleotides in the Nervous SystemPittenger C, Nestler E, Duman R. Chapter 22 Cyclic Nucleotides in the Nervous System 2012, 423-441. DOI: 10.1016/b978-0-12-374947-5.00022-5.
  • O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic miceTown T, Laouar Y, Pittenger C, Mori T, Szekely C, Tan J, Duman R, Flavell R. O4‐02–06: Blocking Tgf‐β‐smad 2/3 innate immune signaling mitigates Alzheimer‐like pathology in transgenic mice Alzheimer's & Dementia 2008, 4: t187-t188. DOI: 10.1016/j.jalz.2008.05.514.
  • Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for TrichotillomaniaBloch M, Landeros-Weisenberger A, Dombrowski P, Nudel J, Pittenger C, Leckman J, Kelmendi B, Wegner R, Coric V. Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania Biological Psychiatry 2008, 63: e34-e35. DOI: 10.1016/j.biopsych.2008.01.022.
  • Are there Biological Commonalities among Different Psychiatric Disorders?Pittenger C, Etkin A. Are there Biological Commonalities among Different Psychiatric Disorders? 2008, 243-256. DOI: 10.1002/9780470515167.ch15.
  • Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP KinasePatterson S, Pittenger C, Morozov A, Martin K, Scanlin H, Drake C, Kandel E. Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase Neuron 2001, 32: 123-140. PMID: 11604144, DOI: 10.1016/s0896-6273(01)00443-3.
  • The past, the future and the biology of memory storageKandel E, Pittenger C. The past, the future and the biology of memory storage Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 2027-2052. PMID: 10670023, PMCID: PMC1692699, DOI: 10.1098/rstb.1999.0542.

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral ResearchObsessions or ideations: First Person Suicide Images study in OCD
Mental Health & Behavioral ResearchBrain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
Mental Health & Behavioral ResearchEfficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
Mental Health & Behavioral ResearchEfficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder
Diseases of the Nervous System; Mental Health & Behavioral ResearchTeen Brain and Behavior Study
Child Development & Autism; Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchGenetic and molecular studies of developmental neuropsychiatric disorders
Diseases of the Nervous System; Mental Health & Behavioral ResearchBiomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
Diseases of the Nervous System; Mental Health & Behavioral ResearchNeurofeedback for Obsessive-Compulsive Disorder
Diseases of the Nervous SystemPET and MRI in OCD and/or Tic disorders
Effects of Repeated Psilocybin Dosing in OCD
Edit Profile