Skip to Main Content

Andre Levchenko

John C. Malone Professor of Biomedical Engineering

Research Summary

The key research focus of my lab is to understand the complex signaling & decision making networks in eukaryotic cells. We combine experimental & theoretical approaches to analyze specific signaling pathways & networks and analyze the consequences of the signaling processes in regulating diverse cellular phenotypes, in the context of healthy & pathologic cell & tissue states.

Coauthors

Research Interests

Cell Communication; Signal Transduction; Microfluidics; Systems Biology

Selected Publications

  • 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENTScanlon V, Thompson E, Lawton B, Kochugaeva M, Kang E, Eskow N, Sanchez P, Bobbalan S, Cenci M, Pena-Carmona G, Laumas A, Anderson R, Reed F, Blau H, Levchenko A, Krause D. 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENT Experimental Hematology 2022, 111: s135. DOI: 10.1016/j.exphem.2022.07.237.
  • CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMASchiapparelli P, Meade P, Miranda-Herrera P, Bechtle A, Issacs F, Levchenko A, Rinehart J, Quinones-Hinojosa A. CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA Neuro-Oncology 2020, 22: ii29-ii29. PMCID: PMC7650317, DOI: 10.1093/neuonc/noaa215.120.
  • Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasisMukherjee R, Vanaja K, Boyer J, Qiu J, Chen X, de Stanchina E, Chandarlapaty S, Levchenko A, Rosen N. Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis Cancer Research 2020, 80: 1090-1090. DOI: 10.1158/1538-7445.am2020-1090.
  • Abstract 5506: A computational model for the PI3K/Akt/mTOR pathway predicts PTEN as a negative feedback loopVanaja K, Mukherjee R, Rosen N, Levchenko A. Abstract 5506: A computational model for the PI3K/Akt/mTOR pathway predicts PTEN as a negative feedback loop Cancer Research 2020, 80: 5506-5506. DOI: 10.1158/1538-7445.am2020-5506.
  • Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal DynamicsKeyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Ling M, Trejo J, Levchenko A, Zhang J. Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00680.
  • Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict PotentialScanlon V, Kochugaeva M, Xavier-Ferrucio J, Lu Y, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Holbrook C, Tri Van Ho A, Blau H, Levchenko A, Krause D. Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential Blood 2019, 134: 1190-1190. DOI: 10.1182/blood-2019-131204.
  • Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. K, Afzal J, Suhail Y, Chang H, Dang C, Levchenko A. Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response 2019, 4359-4359. DOI: 10.1158/1538-7445.sabcs18-4359.
  • Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. K, Afzal J, Suhail Y, Chang H, Dang C, Levchenko A. Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response Cancer Research 2019, 79: 4359-4359. DOI: 10.1158/1538-7445.am2019-4359.
  • Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in LungRaredon M, Adams T, Schupp J, Suhail Y, Leiby K, Greaney A, Boffa D, Levchenko A, Kaminski N, Niklason L. Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in Lung 2019, a6073-a6073. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6073.
  • CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATIONShah S, David J, Tippens N, Mohyeldin A, Martinez J, Ganaha S, Levchenko A, Palena C, Quinones-Hinojosa A. CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION Neuro-Oncology 2016, 18: vi41-vi41. DOI: 10.1093/neuonc/now212.166.
  • 217 YAP Is Ready to Rac and RhoShah S, Tippens N, Park J, Mohyeldin A, Vela G, Martinez-Gutierrez J, Margolis S, Schmidt S, Levchenko A, Quinones-Hinojosa A. 217 YAP Is Ready to Rac and Rho Neurosurgery 2016, 63: 185. DOI: 10.1227/01.neu.0000489786.22041.2d.
  • Fundamental Limits to the Precision of Multicellular SensingFancher S, Levchenko A, Nemenman I, Mugler A. Fundamental Limits to the Precision of Multicellular Sensing Biophysical Journal 2016, 110: 350a. DOI: 10.1016/j.bpj.2015.11.1884.
  • Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell BehaviorKshitiz, Afzal J, Chang H, Goyal R, Levchenko A. Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell Behavior Current Stem Cell Reports 2016, 2: 62-72. DOI: 10.1007/s40778-016-0033-9.
  • Abstract 19641: Novel Microprinted Elisa Platform for High Throughput Screening of Protein Secretion Reveals a Comprehensive Strategy to Prevent Ischemia Reperfusion Induced ApoptosisKz K, Ellison D, Afzal J, Hubbi M, Bernard S, Goyal R, Chang C, Abraham R, Levchenko A. Abstract 19641: Novel Microprinted Elisa Platform for High Throughput Screening of Protein Secretion Reveals a Comprehensive Strategy to Prevent Ischemia Reperfusion Induced Apoptosis Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.19641.
  • TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASIONAbbadi S, Rodarte J, Abutaleb A, Lavell E, Smith C, Ruff W, Schiller J, Olivi A, Levchenko A, Guerrero-Cazares H, Quinones-Hinojosa A. TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION Neuro-Oncology 2014, 16: v213-v213. PMCID: PMC4218619, DOI: 10.1093/neuonc/nou278.1.
  • CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMAShah S, Tippens N, Park J, Mohyeldin A, Vela G, Levchenko A, Quinones-Hinojosa A. CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMA Neuro-Oncology 2014, 16: v57-v58. PMCID: PMC4217989, DOI: 10.1093/neuonc/nou242.31.
  • Abstract 5422: Human GBM-derived brain tumor stem cells resist glycolysis inhibition through Glucose 6 phosphatase: a potential clinical implication in the treatment of recurrent brain tumors.Abbadi S, Guerrero-Cazares H, Abutaleb A, Smith C, Ruff W, Schiller J, Levchenko A, Quinones-Hinojosa A. Abstract 5422: Human GBM-derived brain tumor stem cells resist glycolysis inhibition through Glucose 6 phosphatase: a potential clinical implication in the treatment of recurrent brain tumors. Cancer Research 2013, 73: 5422-5422. DOI: 10.1158/1538-7445.am2013-5422.
  • Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasisChaturvedi P, Gilkes D, Wong C, Kshitiz K, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza G. Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis Journal Of Clinical Investigation 2013, 123: 1402-1402. PMCID: PMC3674862, DOI: 10.1172/jci69244.
  • Illuminating Passive Permeability Barrier of Primary Cilia using Novel Diffusion Trap TechniqueInoue T, Lin Y, Lin B, Phua S, Jiao J, Levchenko A, Niewiadomski P, Rohatgi R, Nakamura H, Inoue T. Illuminating Passive Permeability Barrier of Primary Cilia using Novel Diffusion Trap Technique Biophysical Journal 2013, 104: 31a-32a. DOI: 10.1016/j.bpj.2012.11.212.
  • Novel Physical Attributes Of Airway Smooth Muscle In The Pathogenesis Of AsthmaAn S, Levchenko A, Ahn K, Kogut P, Koziel-White C, Wang R, Lee D, Camoretti-Mercado B, Panettieri R, Solway J. Novel Physical Attributes Of Airway Smooth Muscle In The Pathogenesis Of Asthma 2012, a2694-a2694. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2694.
  • ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta CellsGanesan A, Levchenko A, Zhang J. ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta Cells Biophysical Journal 2012, 102: 507a. DOI: 10.1016/j.bpj.2011.11.2777.
  • Science Signaling Podcast: 4 October 2011Levchenko A, VanHook A. Science Signaling Podcast: 4 October 2011 Science Signaling 2011, 4 DOI: 10.1126/scisignal.2002543.
  • PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta CellsGanesan A, Ni Q, Aye-Han N, Gao X, Allen M, Levchenko A, Zhang J. PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta Cells Biophysical Journal 2011, 100: 517a. DOI: 10.1016/j.bpj.2010.12.3023.
  • Using Lab-on-a-Chip Technologies for Stem Cell BiologyGupta K, Kim D, Ellison D, Smith C, Levchenko A. Using Lab-on-a-Chip Technologies for Stem Cell Biology 2010, 483-498. DOI: 10.1007/978-1-60761-860-7_30.
  • Tissue engineered cardiac stem cell grafts for repairing heart with myocardial infarctionKim D, Smith R, Gupta K, Kim P, Suh K, Marban E, Levchenko A. Tissue engineered cardiac stem cell grafts for repairing heart with myocardial infarction The FASEB Journal 2010, 24: 599.11-599.11. DOI: 10.1096/fasebj.24.1_supplement.599.11.
  • MICROPATTERNED POLYMER STRUCTURES FOR CELL AND TISSUE ENGINEERINGJang K, Kim D, Kim S, Levchenko A, Suh K. MICROPATTERNED POLYMER STRUCTURES FOR CELL AND TISSUE ENGINEERING 2010, 101-120. DOI: 10.1142/9789814295680_0005.
  • Science Signaling Podcast: 23 June 2009Levchenko A, VanHook A. Science Signaling Podcast: 23 June 2009 Science Signaling 2009, 2 DOI: 10.1126/scisignal.276pc11.
  • Investigating transient and prolonged VEGF signaling through regulation of intracellular calciumNoren D, Levchenko A, Popel A. Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium The FASEB Journal 2009, 23: 767.15-767.15. DOI: 10.1096/fasebj.23.1_supplement.767.15.
  • Guided Cell Migration on Microtextured Substrates with Variable Local Density and AnisotropyKim D, Seo C, Han K, Kwon K, Levchenko A, Suh K. Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy Advanced Functional Materials 2009, 19: 1579-1586. DOI: 10.1002/adfm.200801174.
  • Oscillatory Phosphorylation of Yeast Fus3 MAP Kinase Controls Periodic Gene Expression and MorphogenesisHilioti Z, Sabbagh W, Paliwal S, Bergmann A, Goncalves M, Bardwell L, Levchenko A. Oscillatory Phosphorylation of Yeast Fus3 MAP Kinase Controls Periodic Gene Expression and Morphogenesis Current Biology 2008, 18: 1897. DOI: 10.1016/j.cub.2008.11.024.
  • Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and ApplicationsCheong R, Levchenko A. Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications 2006 DOI: 10.1002/3527600906.mcb.200500006.
  • Micro Fluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure ModelCho H, Groisman A, Campbell J, Flores S, Levchenko A. Micro Fluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure Model 2006, 96-96. DOI: 10.1109/bmn.2006.330906.
  • Microfluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure ModelCho H, Groisman A, Campbell J, Flores S, Levchenko A. Microfluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure Model 2006, 14-14. DOI: 10.1109/bmn.2006.330900.
  • Computational Modeling in GlycosylationMurrell M, Yarema K, Levchenko A. Computational Modeling in Glycosylation 2005, 247-288. DOI: 10.1201/9781420027631.ch8.
  • The Systems Biology of GlycosylationMurrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation ChemInform 2004, 35: no-no. DOI: 10.1002/chin.200449270.
  • Responding to directional cues: a tale of two cells [biochemical signaling pathways]Paliwal S, Ma L, Krishnan J, Levchenko A, Iglesias P. Responding to directional cues: a tale of two cells [biochemical signaling pathways] IEEE Control Systems Magazine 2004, 24: 77-90. DOI: 10.1109/mcs.2004.1316655.
  • A general framework for achieving integral control in chemotactic biological signaling mechanismsIglesias P, Levchenko A. A general framework for achieving integral control in chemotactic biological signaling mechanisms 2001, 1: 843-848 vol.1. DOI: 10.1109/cdc.2001.980211.