Andre Levchenko

• Daniel Boffa
• Diane Krause
• Jesse Rinehart
• Naftali Kaminski
• Stefania Nicoli

Cell Communication; Signal Transduction; Microfluidics; Systems Biology

• Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cellsKshitiz, Afzal J, Suhail Y, Chang H, Hubbi M, Hamidzadeh A, Goyal R, Liu Y, Sun P, Nicoli S, Dang C, Levchenko A. Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells. Cell Systems 2022, 13: 1048-1064.e7. PMID: 36462504, PMCID: PMC10012408, DOI: 10.1016/j.cels.2022.11.003.
• 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENTScanlon V, Thompson E, Lawton B, Kochugaeva M, Kang E, Eskow N, Sanchez P, Bobbalan S, Cenci M, Pena-Carmona G, Laumas A, Anderson R, Reed F, Blau H, Levchenko A, Krause D. 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENT. Experimental Hematology 2022, 111: s135. DOI: 10.1016/j.exphem.2022.07.237.
• CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMASchiapparelli P, Meade P, Miranda-Herrera P, Bechtle A, Issacs F, Levchenko A, Rinehart J, Quinones-Hinojosa A. CSIG-08. TARGETING ION TRANSPORT-REGULATORY KINASES AS A NOVEL TREATMENT FOR GLIOBLASTOMA. Neuro-Oncology 2020, 22: ii29-ii29. PMCID: PMC7650317, DOI: 10.1093/neuonc/noaa215.120.
• Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasisMukherjee R, Vanaja K, Boyer J, Qiu J, Chen X, de Stanchina E, Chandarlapaty S, Levchenko A, Rosen N. Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Cancer Research 2020, 80: 1090-1090. DOI: 10.1158/1538-7445.am2020-1090.
• Abstract 5506: A computational model for the PI3K/Akt/mTOR pathway predicts PTEN as a negative feedback loopVanaja K, Mukherjee R, Rosen N, Levchenko A. Abstract 5506: A computational model for the PI3K/Akt/mTOR pathway predicts PTEN as a negative feedback loop. Cancer Research 2020, 80: 5506-5506. DOI: 10.1158/1538-7445.am2020-5506.
• Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal DynamicsKeyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Ling M, Trejo J, Levchenko A, Zhang J. Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00680.
• Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict PotentialScanlon V, Kochugaeva M, Xavier-Ferrucio J, Lu Y, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Holbrook C, Van Ho A, Tri Van Ho A, Blau H, Levchenko A, Krause D. Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential. Blood 2019, 134: 1190-1190. DOI: 10.1182/blood-2019-131204.
• Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. K, Afzal J, Suhail Y, Chang H, Dang C, Levchenko A. Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. 2019, 4359-4359. DOI: 10.1158/1538-7445.sabcs18-4359.
• Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. K, Afzal J, Suhail Y, Chang H, Dang C, Levchenko A. Abstract 4359: Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. Cancer Research 2019, 79: 4359-4359. DOI: 10.1158/1538-7445.am2019-4359.
• Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in LungRaredon M, Adams T, Schupp J, Suhail Y, Leiby K, Greaney A, Boffa D, Levchenko A, Kaminski N, Niklason L. Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in Lung. 2019, a6073-a6073. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6073.
• CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATIONShah S, David J, Tippens N, Mohyeldin A, Martinez J, Ganaha S, Levchenko A, Palena C, Quinones-Hinojosa A. CSIG-05. PUTTING THE BRAKES ON BRACHYURY: IDENTIFYING AND TARGETING A CONSERVED TRANSCRIPTIONAL NETWORK THAT DRIVES PRIMARY AND METASTATIC TUMOR INITIATION AND PROPAGATION. Neuro-Oncology 2016, 18: vi41-vi41. DOI: 10.1093/neuonc/now212.166.
• 217 YAP Is Ready to Rac and RhoShah S, Tippens N, Park J, Mohyeldin A, Vela G, Martinez-Gutierrez J, Margolis S, Schmidt S, Levchenko A, Quinones-Hinojosa A. 217 YAP Is Ready to Rac and Rho. Neurosurgery 2016, 63: 185. DOI: 10.1227/01.neu.0000489786.22041.2d.
• Fundamental Limits to the Precision of Multicellular SensingFancher S, Levchenko A, Nemenman I, Mugler A. Fundamental Limits to the Precision of Multicellular Sensing. Biophysical Journal 2016, 110: 350a. DOI: 10.1016/j.bpj.2015.11.1884.
• Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell BehaviorKshitiz, Afzal J, Chang H, Goyal R, Levchenko A. Mechanics of Microenvironment as Instructive Cues Guiding Stem Cell Behavior. Current Stem Cell Reports 2016, 2: 62-72. DOI: 10.1007/s40778-016-0033-9.
• Erratum: Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancerFeng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, Denduluri A, Chaichana K, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quiñones-Hinojosa A. Erratum: Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death & Disease 2015, 6: e1797-e1797. PMID: 26111059, PMCID: PMC4669846, DOI: 10.1038/cddis.2015.176.
• Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancerFeng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, Denduluri A, Chaichana K, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quiñones-Hinojosa A. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death & Disease 2014, 5: e1567-e1567. PMID: 25501828, PMCID: PMC4649837, DOI: 10.1038/cddis.2014.521.
• Abstract 19641: Novel Microprinted Elisa Platform for High Throughput Screening of Protein Secretion Reveals a Comprehensive Strategy to Prevent Ischemia Reperfusion Induced ApoptosisKz K, Ellison D, Afzal J, Hubbi M, Bernard S, Goyal R, Chang C, Abraham R, Levchenko A. Abstract 19641: Novel Microprinted Elisa Platform for High Throughput Screening of Protein Secretion Reveals a Comprehensive Strategy to Prevent Ischemia Reperfusion Induced Apoptosis. Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.19641.
• TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASIONAbbadi S, Rodarte J, Abutaleb A, Lavell E, Smith C, Ruff W, Schiller J, Olivi A, Levchenko A, Guerrero-Cazares H, Quinones-Hinojosa A. TM-01IDENTIFICATION OF GLUCOSE-6-PHOSPHATASE ALPHA AS A KEY METABOLIC REGULATOR FOR GLIOBLASTOMA CELL INVASION. Neuro-Oncology 2014, 16: v213-v213. PMCID: PMC4218619, DOI: 10.1093/neuonc/nou278.1.
• CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMAShah S, Tippens N, Park J, Mohyeldin A, Vela G, Levchenko A, Quinones-Hinojosa A. CS-31A NOVEL YAP-DRIVEN MIGRATION AND INVASION SIGNALING PATHWAY PREDICTS POOR OUTCOME IN GLIOBLASTOMA. Neuro-Oncology 2014, 16: v57-v58. PMCID: PMC4217989, DOI: 10.1093/neuonc/nou242.31.
• Abstract 5422: Human GBM-derived brain tumor stem cells resist glycolysis inhibition through Glucose 6 phosphatase: a potential clinical implication in the treatment of recurrent brain tumors.Abbadi S, Guerrero-Cazares H, Abutaleb A, Smith C, Ruff W, Schiller J, Levchenko A, Quinones-Hinojosa A. Abstract 5422: Human GBM-derived brain tumor stem cells resist glycolysis inhibition through Glucose 6 phosphatase: a potential clinical implication in the treatment of recurrent brain tumors. Cancer Research 2013, 73: 5422-5422. DOI: 10.1158/1538-7445.am2013-5422.
• Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasisChaturvedi P, Gilkes D, Wong C, Kshitiz K, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza G. Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis. Journal Of Clinical Investigation 2013, 123: 1402-1402. PMCID: PMC3674862, DOI: 10.1172/jci69244.
• Illuminating Passive Permeability Barrier of Primary Cilia using Novel Diffusion Trap TechniqueInoue T, Lin Y, Lin B, Phua S, Jiao J, Levchenko A, Niewiadomski P, Rohatgi R, Nakamura H, Inoue T. Illuminating Passive Permeability Barrier of Primary Cilia using Novel Diffusion Trap Technique. Biophysical Journal 2013, 104: 31a-32a. DOI: 10.1016/j.bpj.2012.11.212.
• Novel Physical Attributes Of Airway Smooth Muscle In The Pathogenesis Of AsthmaAn S, Levchenko A, Ahn K, Kogut P, Koziel-White C, Wang R, Lee D, Camoretti-Mercado B, Panettieri R, Solway J. Novel Physical Attributes Of Airway Smooth Muscle In The Pathogenesis Of Asthma. 2012, a2694-a2694. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2694.
• ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta CellsGanesan A, Levchenko A, Zhang J. ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta Cells. Biophysical Journal 2012, 102: 507a. DOI: 10.1016/j.bpj.2011.11.2777.
• Science Signaling Podcast: 4 October 2011Levchenko A, VanHook A. Science Signaling Podcast: 4 October 2011. Science Signaling 2011, 4 DOI: 10.1126/scisignal.2002543.
• PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta CellsGanesan A, Ni Q, Aye-Han N, Gao X, Allen M, Levchenko A, Zhang J. PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta Cells. Biophysical Journal 2011, 100: 517a. DOI: 10.1016/j.bpj.2010.12.3023.
• Using Lab-on-a-Chip Technologies for Stem Cell BiologyGupta K, Kim D, Ellison D, Smith C, Levchenko A. Using Lab-on-a-Chip Technologies for Stem Cell Biology. 2010, 483-498. DOI: 10.1007/978-1-60761-860-7_30.
• Tissue engineered cardiac stem cell grafts for repairing heart with myocardial infarctionKim D, Smith R, Gupta K, Kim P, Suh K, Marban E, Levchenko A. Tissue engineered cardiac stem cell grafts for repairing heart with myocardial infarction. The FASEB Journal 2010, 24: 599.11-599.11. DOI: 10.1096/fasebj.24.1_supplement.599.11.
• MICROPATTERNED POLYMER STRUCTURES FOR CELL AND TISSUE ENGINEERINGJang K, Kim D, Kim S, Levchenko A, Suh K. MICROPATTERNED POLYMER STRUCTURES FOR CELL AND TISSUE ENGINEERING. 2010, 101-120. DOI: 10.1142/9789814295680_0005.
• Science Signaling Podcast: 23 June 2009Levchenko A, VanHook A. Science Signaling Podcast: 23 June 2009. Science Signaling 2009, 2 DOI: 10.1126/scisignal.276pc11.
• Guided Cell Migration on Microtextured Substrates with Variable Local Density and AnisotropyKim D, Seo C, Han K, Kwon K, Levchenko A, Suh K. Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Advanced Functional Materials 2009, 19: 1579-1586. DOI: 10.1002/adfm.200801174.
• Investigating transient and prolonged VEGF signaling through regulation of intracellular calciumNoren D, Levchenko A, Popel A. Investigating transient and prolonged VEGF signaling through regulation of intracellular calcium. The FASEB Journal 2009, 23: 767.15-767.15. DOI: 10.1096/fasebj.23.1_supplement.767.15.
• Oscillatory Phosphorylation of Yeast Fus3 MAP Kinase Controls Periodic Gene Expression and MorphogenesisHilioti Z, Sabbagh W, Paliwal S, Bergmann A, Goncalves M, Bardwell L, Levchenko A. Oscillatory Phosphorylation of Yeast Fus3 MAP Kinase Controls Periodic Gene Expression and Morphogenesis. Current Biology 2008, 18: 1897. DOI: 10.1016/j.cub.2008.11.024.
• Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and ApplicationsCheong R, Levchenko A. Transcription Factor NF‐κ B: Function, Structure, Regulation, Pathways, and Applications. 2006 DOI: 10.1002/3527600906.mcb.200500006.
• Micro Fluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure ModelCho H, Groisman A, Campbell J, Flores S, Levchenko A. Micro Fluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure Model. 2006, 96-96. DOI: 10.1109/bmn.2006.330906.
• Microfluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure ModelCho H, Groisman A, Campbell J, Flores S, Levchenko A. Microfluidic Chemostat with Deformable Membranes: Intracellular Biofilm-Like Structure Model. 2006, 14-14. DOI: 10.1109/bmn.2006.330900.
• Dynamic Properties of Network Motifs Contribute to Biological Network OrganizationPrill R, Iglesias P, Levchenko A. Dynamic Properties of Network Motifs Contribute to Biological Network Organization. PLOS Biology 2005, 3: e343. PMID: 16187794, PMCID: PMC1239925, DOI: 10.1371/journal.pbio.0030343.
• A microfluidic chemostat for experiments with bacterial and yeast cellsGroisman A, Lobo C, Cho H, Campbell J, Dufour Y, Stevens A, Levchenko A. A microfluidic chemostat for experiments with bacterial and yeast cells. Nature Methods 2005, 2: 685-689. PMID: 16118639, DOI: 10.1038/nmeth784.
• Proteomics takes stem cell analyses to another levelLevchenko A. Proteomics takes stem cell analyses to another level. Nature Biotechnology 2005, 23: 828-830. PMID: 16003369, DOI: 10.1038/nbt0705-828.
• Computational Modeling in GlycosylationMurrell M, Yarema K, Levchenko A. Computational Modeling in Glycosylation. 2005, 247-288. DOI: 10.1201/9781420027631.ch8.
• Comment on "Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression"Barken D, Wang C, Kearns J, Cheong R, Hoffmann A, Levchenko A. Comment on "Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression". Science 2005, 308: 52a-52a. PMID: 15802586, PMCID: PMC2821939, DOI: 10.1126/science.1107904.
• Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cellsLevchenko A, Mehta B, Niu X, Kang G, Villafania L, Way D, Polycarpe D, Sadelain M, Larson S. Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 1933-1938. PMID: 15671173, PMCID: PMC545583, DOI: 10.1073/pnas.0401851102.
• The Systems Biology of GlycosylationMurrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemInform 2004, 35: no-no. DOI: 10.1002/chin.200449270.
• The Systems Biology of GlycosylationMurrell M, Yarema K, Levchenko A. The Systems Biology of Glycosylation. ChemBioChem 2004, 5: 1334-1347. PMID: 15457533, DOI: 10.1002/cbic.200400143.
• Responding to directional cues: a tale of two cells [biochemical signaling pathways]Paliwal S, Ma L, Krishnan J, Levchenko A, Iglesias P. Responding to directional cues: a tale of two cells [biochemical signaling pathways]. IEEE Control Systems Magazine 2004, 24: 77-90. DOI: 10.1109/mcs.2004.1316655.
• Regulatory modules that generate biphasic signal response in biological systems.Levchenko A, Bruck J, Sternberg P. Regulatory modules that generate biphasic signal response in biological systems. IET Systems Biology 2004, 1: 139-48. PMID: 17052124, DOI: 10.1049/sb:20045014.
• GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNsHilioti Z, Gallagher D, Low-Nam S, Ramaswamy P, Gajer P, Kingsbury T, Birchwood C, Levchenko A, Cunningham K. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes & Development 2003, 18: 35-47. PMID: 14701880, PMCID: PMC314273, DOI: 10.1101/gad.1159204.
• Dynamical and integrative cell signaling: challenges for the new biologyLevchenko A. Dynamical and integrative cell signaling: challenges for the new biology. Biotechnology And Bioengineering 2003, 84: 773-782. PMID: 14708118, DOI: 10.1002/bit.10854.
• Allovalency: A Case of Molecular EntanglementLevchenko A. Allovalency: A Case of Molecular Entanglement. Current Biology 2003, 13: r876-r878. PMID: 14614843, DOI: 10.1016/j.cub.2003.10.049.
• Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulationsShapiro B, Levchenko A, Meyerowitz E, Wold B, Mjolsness E. Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics 2003, 19: 677-678. PMID: 12651737, DOI: 10.1093/bioinformatics/btg042.
• The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene ActivationHoffmann A, Levchenko A, Scott M, Baltimore D. The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation. Science 2002, 298: 1241-1245. PMID: 12424381, DOI: 10.1126/science.1071914.
• Modeling the Cell's Guidance SystemIglesias P, Levchenko A. Modeling the Cell's Guidance System. Science Signaling 2002, 2002: re12. PMID: 12209053, DOI: 10.1126/stke.2002.148.re12.
• Models of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and NeutrophilsLevchenko A, Iglesias P. Models of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and Neutrophils. Biophysical Journal 2002, 82: 50-63. PMID: 11751295, PMCID: PMC1302448, DOI: 10.1016/s0006-3495(02)75373-3.
• A general framework for achieving integral control in chemotactic biological signaling mechanismsIglesias P, Levchenko A. A general framework for achieving integral control in chemotactic biological signaling mechanisms. 2001, 1: 843-848 vol.1. DOI: 10.1109/cdc.2001.980211.
• Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold propertiesLevchenko A, Bruck J, Sternberg P. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5818-5823. PMID: 10823939, PMCID: PMC18517, DOI: 10.1073/pnas.97.11.5818.
• Evaluation of 11C-colchicine for PET imaging of multiple drug resistance.Levchenko A, Mehta B, Lee J, Humm J, Augensen F, Squire O, Kothari P, Finn R, Leonard E, Larson S. Evaluation of 11C-colchicine for PET imaging of multiple drug resistance. Journal Of Nuclear Medicine 2000, 41: 493-501. PMID: 10716325.