Janghoo Lim, PhD
Professor of Genetics and Neuroscience; co-Director of Graduate Studies, GeneticsDownloadHi-Res Photo
Cards
Appointments
Genetics
Fully Joint
Neuroscience
Fully Joint
Contact Info
Additional Titles
co-Director of Graduate Studies, Genetics
Appointments
Genetics
Fully Joint
Neuroscience
Fully Joint
Contact Info
Additional Titles
co-Director of Graduate Studies, Genetics
Appointments
Genetics
Fully Joint
Neuroscience
Fully Joint
Contact Info
Additional Titles
co-Director of Graduate Studies, Genetics
About
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Titles
Professor of Genetics and Neuroscience; co-Director of Graduate Studies, Genetics
co-Director of Graduate Studies, Genetics
Biography
Janghoo Lim received his undergraduate and master’s degrees in South Korea. He completed his Ph.D. and postdoctoral training at Baylor College of Medicine in Houston, Texas. He joined Yale in 2010 and is currently a Professor in the Departments of Genetics and of Neuroscience.
Last Updated on July 02, 2025.
Appointments
Genetics
ProfessorFully JointNeuroscience
ProfessorFully Joint
Other Departments & Organizations
- Genetics
- Interdepartmental Neuroscience Program
- Molecular Cell Biology, Genetics and Development
- Neural Disorders
- Neuroscience
- Neuroscience Track
- Program in Cellular Neuroscience, Neurodegeneration and Repair
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- PhD
- Baylor College of Medicine (2004)
- MS
- Korea Advanced Institute of Science and Technology, Daejeon, Korea (1999)
- BS
- Chonnam National University, Gwangju, Korea (1997)
Research
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Overview
Medical Research Interests
Developmental Disabilities; Mental Disorders; Motor Neuron Disease; Neurodegenerative Diseases; Neuromuscular Diseases; Spinocerebellar Ataxias
ORCID
0000-0002-5331-210X- View Lab Website
The Lim Lab at Yale
Research at a Glance
Yale Co-Authors
Frequent collaborators of Janghoo Lim's published research.
Publications Timeline
A big-picture view of Janghoo Lim's research output by year.
Research Interests
Research topics Janghoo Lim is interested in exploring.
Leon Tejwani, PhD
Neha Gogia
Former YSMYoungseob Jung
David van Dijk, PhD, MSc, BSc
Diane Krause, MD, PhD
Jennifer Yoon
Former YSM
24Publications
377Citations
Spinocerebellar Ataxias
Neurodegenerative Diseases
Publications
2026
Locus‐Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder
Khalid M, Mukhtar M, Saqlain M, Sami A, Baig S, Nawaz A, Moeez S, Ayaz C, Fatima T, Fatima F, Lim J, Nawaz M, Raja G. Locus‐Specific Genetic Associations at the DAOA Gene in Schizophrenia and Bipolar Disorder. Advanced Genetics 2026, 7 DOI: 10.1002/ggn2.202500064.Peer-Reviewed Original ResearchPGC-1α pathway dysregulation disrupts myofiber specification in a mouse model of SBMA
Kuo C, Chopp L, Yu Z, Ni L, Zhao H, Lim J, Lieberman A. PGC-1α pathway dysregulation disrupts myofiber specification in a mouse model of SBMA. JCI Insight 2026 PMID: 42096288, DOI: 10.1172/jci.insight.203215.Peer-Reviewed Original ResearchAltmetricOligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1
Lee C, Grijalva R, Tejwani L, Bae E, Chase A, Ro H, Kim H, Olmos V, Orengo J, Lim J. Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1. Journal Of Clinical Investigation 2026, 136: e195723. PMID: 42113962, PMCID: PMC13262716, DOI: 10.1172/jci195723.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy
Lee C, Lim J. Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy. Neurotherapeutics 2025, 22: e00771. PMID: 41107106, PMCID: PMC12664553, DOI: 10.1016/j.neurot.2025.e00771.Peer-Reviewed Original ResearchCitationsPeripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model
Lee C, Yu Z, Kuo C, Tejwani L, Grijalva R, Bae E, Zhao H, Lim J, Lieberman A. Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model. Journal Of Clinical Investigation 2025, 135: e182955. PMID: 40875460, PMCID: PMC12578385, DOI: 10.1172/jci182955.Peer-Reviewed Original ResearchCitations
2023
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Tejwani L, Ravindra N, Lee C, Cheng Y, Nguyen B, Luttik K, Ni L, Zhang S, Morrison L, Gionco J, Xiang Y, Yoon J, Ro H, Haidery F, Grijalva R, Bae E, Kim K, Martuscello R, Orr H, Zoghbi H, McLoughlin H, Ranum L, Shakkottai V, Faust P, Wang S, van Dijk D, Lim J. Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1. Neuron 2023, 112: 362-383.e15. PMID: 38016472, PMCID: PMC10922326, DOI: 10.1016/j.neuron.2023.10.039.Peer-Reviewed Original ResearchCitationsAltmetricDysregulation of alternative splicing in spinocerebellar ataxia type 1
Olmos V, Thompson E, Gogia N, Luttik K, Veeranki V, Ni L, Sim S, Chen K, Krause D, Lim J. Dysregulation of alternative splicing in spinocerebellar ataxia type 1. Human Molecular Genetics 2023, 33: 138-149. PMID: 37802886, PMCID: PMC10979408, DOI: 10.1093/hmg/ddad170.Peer-Reviewed Original ResearchCitationsAltmetricReduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Tejwani L, Jung Y, Kokubu H, Sowmithra S, Ni L, Lee C, Sanders B, Lee P, Xiang Y, Luttik K, Soriano A, Yoon J, Park J, Ro H, Ju H, Liao C, Tieze S, Rigo F, Jafar-Nejad P, Lim J. Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration. Journal Of Clinical Investigation 2023, 133: e138207. PMID: 37384409, PMCID: PMC10425213, DOI: 10.1172/jci138207.Peer-Reviewed Original ResearchCitationsAltmetric
2022
A Novel Missense Mutation in ERCC8 Co-Segregates with Cerebellar Ataxia in a Consanguineous Pakistani Family
Gauhar Z, Tejwani L, Abdullah U, Saeed S, Shafique S, Badshah M, Choi J, Dong W, Nelson-Williams C, Lifton RP, Lim J, Raja GK. A Novel Missense Mutation in ERCC8 Co-Segregates with Cerebellar Ataxia in a Consanguineous Pakistani Family. Cells 2022, 11: 3090. PMID: 36231052, PMCID: PMC9564319, DOI: 10.3390/cells11193090.Peer-Reviewed Original ResearchCitationsAltmetricIdentifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex
Luttik K, Olmos V, Owens A, Khan A, Yun J, Driessen T, Lim J. Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex. Cells 2022, 11: 2632. PMID: 36078042, PMCID: PMC9454518, DOI: 10.3390/cells11172632.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Blavatnik Development Award
03/01/2026Yale University AwardBlavatnik Family FoundationDetailsUnited Stateshonor Blavatnik Accelerator Award
07/02/2025Yale University AwardBlavatnik Family FoundationDetailsUnited Stateshonor Young Investigator Award for SCA Research
01/01/2014International AwardNational Ataxia FoundationDetailsUnited Stateshonor Child Health Research Award
06/05/2012Regional AwardCharles H. Hood FoundationDetailsUnited Stateshonor Sloan Research Fellowship
02/15/2012International AwardAlfred P. Sloan FoundationDetailsUnited States
News
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News
- October 23, 2025
2025 Yale-KU Forum: Clinical and Basic Neuroscience
- July 08, 2025Source: Yale Ventures
Eight Translational Biotech Projects Selected for 2025 Blavatnik Accelerator Awards
- March 20, 2024
From the journals
- January 09, 2024
The Most Popular Neuroscience Stories of 2023
Get In Touch
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Contacts
Locations
100 College Street
Lab
Rm 330
New Haven, CT 06510
Appointments
203.737.6267
Events
Nov 202630Monday
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