2016
Germline MC1R status influences somatic mutation burden in melanoma
Robles-Espinoza CD, Roberts ND, Chen S, Leacy FP, Alexandrov LB, Pornputtapong N, Halaban R, Krauthammer M, Cui R, Timothy Bishop D, Adams DJ. Germline MC1R status influences somatic mutation burden in melanoma. Nature Communications 2016, 7: 12064. PMID: 27403562, PMCID: PMC4945874, DOI: 10.1038/ncomms12064.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesCohort StudiesFemaleGenetic Predisposition to DiseaseGenetic VariationGerm-Line MutationHair ColorHead and Neck NeoplasmsHumansMaleMelanomaMelanosisMiddle AgedMutationMutation AccumulationNeoplasm InvasivenessPolymorphism, Single NucleotideReceptor, Melanocortin, Type 1Skin NeoplasmsSkin PigmentationConceptsR allelePhenotypic risk factorsCutaneous melanoma riskYears of ageSomatic mutation burdenRisk factorsMutation burdenSun exposureGeneral populationMelanoma riskMutational burdenSun sensitivityMC1R statusMajor genetic determinantMelanoma developmentReceptor geneT mutationMelanomaRed hairGenetic determinantsMutation classesDisruptive variantsBurdenAllelesMelanocortin 1 receptor (MC1R) gene
2002
COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities
Halaban R. COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2002, 13: 3-8. PMID: 12201672, DOI: 10.3727/096504002108747908.Peer-Reviewed Original ResearchMeSH KeywordsGene Expression Regulation, NeoplasticHumansMelanomaMonophenol MonooxygenaseSkin NeoplasmsSkin PigmentationConceptsMelanocyte-specific gene expressionTranscription factor MITFDownregulation of tyrosinaseEpigenetic levelV-ATPaseRate-limiting enzymeTranscriptional activityGene expressionAcidified microenvironmentsAmelanotic melanoma cellsC-MycActivity of tyrosinaseEnhanced glycolysisMelanin synthesisExtracellular acidificationMelanoma tumorsTYR activityMelanoma cellsMetabolic activityPigmentationAnaerobic conditionsTyrosinase activityMetastatic melanocytic lesionsMetabolic changesTyrosinase
1983
Regulation of tyrosinase in human melanocytes grown in culture.
Halaban R, Pomerantz S, Marshall S, Lambert D, Lerner A. Regulation of tyrosinase in human melanocytes grown in culture. Journal Of Cell Biology 1983, 97: 480-488. PMID: 6411733, PMCID: PMC2112541, DOI: 10.1083/jcb.97.2.480.Peer-Reviewed Original ResearchConceptsHuman melanocytesApparent molecular weightMalignant human melanocytesTyrosinase activityMajor biochemical eventsExpression of tyrosinaseSynthesis of melaninRegulation of tyrosinasePosttranslational modificationsImmunoprecipitation experimentsO-glycosylationBiochemical eventsNormal melanocytesMelanocytesMolecular weightProteinEnzymeTyrosinaseTunicamycinAbundanceActivityRegulationHigh levelsLow levelsCulture