2016
RASopathy Gene Mutations in Melanoma
Halaban R, Krauthammer M. RASopathy Gene Mutations in Melanoma. Journal Of Investigative Dermatology 2016, 136: 1755-1759. PMID: 27236105, PMCID: PMC4992636, DOI: 10.1016/j.jid.2016.05.095.Peer-Reviewed Original ResearchConceptsRASopathy mutationsRAS/mitogen-activated protein kinaseRAS/mitogen-activated protein kinase (MAPK) pathwayMitogen-activated protein kinase pathwayMitogen-activated protein kinaseProtein kinase pathwayAmino acid substitutionsNext-generation sequencingProtein kinasePathway genesKinase pathwaySequencing dataDriver genesAcid substitutionsGenomic abnormalitiesMutationsLegius syndromeGenesAbundant mutationsGermline mutationsGene mutationsPathwaySignificant overlapKinaseMelanomagenesisAMPK promotes tolerance to Ras pathway inhibition by activating autophagy
Sanduja S, Feng Y, Mathis RA, Sokol ES, Reinhardt F, Halaban R, Gupta PB. AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene 2016, 35: 5295-5303. PMID: 27041569, PMCID: PMC6086350, DOI: 10.1038/onc.2016.70.Peer-Reviewed Original ResearchConceptsCellular energy sensor AMPEnergy sensor AMPPathway inhibitorTargeted inhibitorsRas-Raf pathwayDrug-tolerant cellsPathway inhibitionOncogenic RasProtein kinaseRaf signalingRas pathway inhibitionReduced growthAMPKAutophagyPathway mutationsCancer cellsResistant cellsKey mechanismPathwayInhibitorsCellsToleranceKinaseSignalingInhibition
2007
XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*
Straszewski-Chavez SL, Visintin IP, Karassina N, Los G, Liston P, Halaban R, Fadiel A, Mor G. XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*. Journal Of Biological Chemistry 2007, 282: 13059-13072. PMID: 17329253, DOI: 10.1074/jbc.m609038200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingApoptosisApoptosis Regulatory ProteinsCell SurvivalCells, CulturedFas ReceptorFemaleHumansIntracellular Signaling Peptides and ProteinsMitochondriaNeoplasm ProteinsPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdTrophoblastsTumor Necrosis Factor-alphaX-Linked Inhibitor of Apoptosis ProteinConceptsThird trimester trophoblast cellsOverexpression of XAF1Fas ligand-induced apoptosisCaspase inhibitory activityTNF-alpha-induced apoptosisMembrane-bound death receptorsNovel regulatory pathwayLigand-induced apoptosisTrophoblast cellsXIAP inactivationMitochondrial pathwayRegulatory pathwaysDeath receptorsProapoptotic proteinsMolecular mechanismsApoptotic cascadeFirst trimester trophoblast cellsDifferential expressionXAF1XAF1 expressionCell survivalInduces ApoptosisGene methylationApoptosisPathway