BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponseBLyS Neutralization Ablates Primary But Not Memory B Cell Pools
Crowley J, Scholz J, Tomayko M, Steinel N, O'Neill P, Miller J, Cho Y, Long V, Ward C, Migone T, Shlomchik M, Cancro M. BLyS Neutralization Ablates Primary But Not Memory B Cell Pools. The FASEB Journal 2008, 22: 366-366. DOI: 10.1096/fasebj.22.2_supplement.366.Peer-Reviewed Original ResearchMemory B cellsB cell poolB cellsMemory B cell poolPeripheral B cell poolRole of BLySSerum BLyS levelsCell poolMarginal zone B cellsTransitional B cellsB cell subsetsMZ B cellsAnti-BlyS antibodyAntigen rechallengeUntreated miceAntibody levelsBLyS levelsAntigen responseCell subsetsIndependent antigensPrimary B cellsAttenuated responseMiceHomeostatic nichesBLyS