2017
B Cell Biology
Sadanand S, Tomayko M. B Cell Biology. 2017, 97-119. DOI: 10.1007/978-3-319-29785-9_7.ChaptersB cell biologyCell biologyB cellsImmune responseEffector functionsB cell-T cell interactionsCell-T cell interactionsB cell developmentCurrent therapeutic mechanismsRegulatory B cellsB-cell depletionB cell responsesAdaptive immune responsesMemory B cellsGerminal center responseEstablishment of toleranceCell developmentCentral playerProtective immunityCell depletionDurable immunityAntigenic targetsAntibody isotypesPlasma cellsTherapeutic mechanism
2008
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponse