2023
Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis
Murphy M, Hwang E, Singh K, Lee T, Cohen J, Damsky W. Machine learning analysis of pretreatment skin biopsies predicts nonresponse to dupilumab in patients with eczematous dermatitis. British Journal Of Dermatology 2023, 190: 132-134. PMID: 37818837, DOI: 10.1093/bjd/ljad389.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, Monoclonal, HumanizedBiopsyEczemaHumansMachine LearningSkinTreatment OutcomeBaseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis
Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.Peer-Reviewed Original ResearchConceptsEczematous dermatitisHistologic featuresTreatment selectionType 1Type 3 inflammationInflammatory skin diseaseCertain histologic featuresSitu hybridization correlatesClinical responseNonresponder groupCytokine profileCytokine stainingAtopic dermatitisCytokine RNAEczematous disordersSitu hybridizationDupilumabIL13 expressionSkin diseasesType 2PatientsDermatitisNonrespondersMolecular heterogeneityImproved response
2020
Psoriasis With Eczematous Features: A Retrospective Clinicopathologic Study.
Noorily AR, Criscito MC, Cohen JM, Brinster NK. Psoriasis With Eczematous Features: A Retrospective Clinicopathologic Study. American Journal Of Dermatopathology 2020, 43: 112-118. PMID: 32618707, DOI: 10.1097/dad.0000000000001711.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultAgedAged, 80 and overBiological ProductsBiopsyDatabases, FactualDermatitis, Allergic ContactEczemaFemaleGlucocorticoidsHumansImmunosuppressive AgentsMaleMiddle AgedPredictive Value of TestsPsoriasisRemission InductionRetrospective StudiesSkinTreatment OutcomeYoung AdultConceptsAllergic contact dermatitisPsoriasis vulgarisClinical characteristicsHistopathological featuresEczematous changesDiagnostic workupSuccessful treatmentContact dermatitisOutcomes of patientsPercent of patientsHalf of patientsRetrospective chart reviewFeatures of psoriasisRetrospective clinicopathologic studyEczematous dermatosesEczematous featuresChart reviewClinicopathologic studyMost patientsSystemic therapyTopical glucocorticoidsHistopathologic featuresChallenging diagnosisClinicopathologic correlationTreatment modalities