2025
Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness
Parikh R, Nayak D, Lin H, Gangaraju V. Drosophila Modulo is Essential for Transposon Silencing and Developmental Robustness. Journal Of Biological Chemistry 2025, 108210. PMID: 39848495, DOI: 10.1016/j.jbc.2025.108210.Peer-Reviewed Original ResearchPIWI-interacting RNAsTransposable elementsDevelopmental robustnessTE silencingSilencing of transposable elementsP-element induced wimpy testisPreserving genome integrityHistone 3 lysineIntrinsic genetic variationPost-transcriptional silencingMammalian nucleolinTransposon RNAsTransposon silencingPiRNA functionPiwi-piRNATE activityGenomic sitesMaternal germlineArgonaute 3Genome integrityTranscriptional silencingGenetic variationEpigenetic regulationPIWIBinding protein
2020
PIWI–piRNA pathway-mediated transposable element repression in Hydra somatic stem cells
Teefy BB, Siebert S, Cazet JF, Lin H, Juliano CE. PIWI–piRNA pathway-mediated transposable element repression in Hydra somatic stem cells. RNA 2020, 26: 550-563. PMID: 32075940, PMCID: PMC7161359, DOI: 10.1261/rna.072835.119.Peer-Reviewed Original ResearchConceptsPIWI-piRNA pathwayTE expressionSomatic stem cellsTransposable elementsTE transcriptsStem cellsFreshwater cnidarianSmall RNA pathwaysTransposable element repressionSomatic cell lineagesGermline of animalsInterstitial stem cellsStem cell populationInterstitial lineageSomatic piRNAsDegradome sequencingEpithelial cellsAncestral functionRNA pathwaysGermline piRNAsPIWI proteinsTE repressionGermline competenceSequence signaturesRNA immunoprecipitation
2014
Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary
Ma X, Wang S, Do T, Song X, Inaba M, Nishimoto Y, Liu LP, Gao Y, Mao Y, Li H, McDowell W, Park J, Malanowski K, Peak A, Perera A, Li H, Gaudenz K, Haug J, Yamashita Y, Lin H, Ni JQ, Xie T. Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary. PLOS ONE 2014, 9: e90267. PMID: 24658126, PMCID: PMC3962343, DOI: 10.1371/journal.pone.0090267.Peer-Reviewed Original ResearchConceptsGerm cell differentiationDrosophila ovaryGermline stem cellsSomatic cellsCell differentiationGerm cellsPiRNA productionMultiple cell typesGSC maintenanceTransposable elementsGerm lineLineage developmentCell typesPiRNA pathway componentsGerm cell maintenanceCell lineage developmentUndifferentiated germ cellsCell-specific knockdownEscort cellsGSC establishmentGSC lossPiwi knockdownPiRNA pathwayGenome stabilityTE transcripts