1996
Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. Journal Of Investigative Dermatology Symposium Proceedings 1996, 1: 136-42. PMID: 9627707.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSquamous cell carcinomaCell carcinomaActinic keratosisBasal cell carcinomaHuman skin cancerP53 tumor suppressor geneP53-mutated cellsSunburn cellsApoptotic keratinocytesSkin cancerP53 mutationsNormal skinTumor initiatorTumor promotionFunction of p53Cellular proofreadingTumor suppressor geneCarcinomaMouse skinClonal expansionP53 geneCarcinogenic DNA lesionsP53 allelePrecancerous cellsSunlight exposure
1994
Sunburn and p53 in the onset of skin cancer
Ziegler A, Jonason A, Leffellt D, Simon J, Sharma H, Kimmelman J, Remington L, Jacks T, Brash D. Sunburn and p53 in the onset of skin cancer. Nature 1994, 372: 773-776. PMID: 7997263, DOI: 10.1038/372773a0.Peer-Reviewed Original ResearchConceptsActinic keratosisP53 mutationsSquamous cell carcinomaP53 tumor suppressor geneP53-mutated cellsCell carcinomaApoptotic keratinocytesSkin cancerTumor initiatorTumor suppressor geneMouse skinClonal expansionPrecancerous cellsTumor promoterCarcinomaSkinTissue responseP53SunburnCell differentiationDNA damageAberrant cell differentiationCellsResponseKeratosis
1991
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ, Pontén J. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 10124-10128. PMID: 1946433, PMCID: PMC52880, DOI: 10.1073/pnas.88.22.10124.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaP53 mutationsMajor epidemiologic risk factorsUV-induced p53 mutationsInvasive squamous cell carcinomaEpidemiologic risk factorsUV-specific mutationsP53 tumor suppressor geneInternal malignancySwedish patientsRisk factorsSkin cancerTumor progressionTT double-base changesTumor suppressor geneCarcinomaHuman cancersCancerDipyrimidine sitesSuppressor geneT substitutionSkinMutationsPatients