2014
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo
Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiomarkersCollagenDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 2Flow CytometryHumansImmunohistochemistryMaleMesenchymal Stem CellsMice, Inbred C57BLMiddle AgedNeovascularization, PhysiologicReal-Time Polymerase Chain ReactionRheologySubcutaneous TissueWound HealingConceptsAdipose-derived mesenchymal stromal cellsMesenchymal stromal cellsGranulation tissueStromal cellsPericyte marker NG2VE-cadherinWound healingPublic health problemMarkers of endotheliumDays of healingSubcutaneous injectionPresence of bFGFFibrin gelAmount of bFGFHAT-MSCsFibrin sealantWound sizeHealth problemsChronic woundsConfocal imaging analysisInsufficient angiogenesis
1999
Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing
Kolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing. Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryBovine collagen matrixMicrographic surgeryWound careControl groupWound healingMinority of patientsPostoperative wound healingSecond intention healingCollagen matrixManagement of defectsWound infectionDressing changesAdverse reactionsImmediate reconstructionAllergic reactionsComplete healingAnatomic sitesRapid wound healingSurgical defectsStudy woundsLarger studySecond intentionBiological dressingSurgery