2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rate
2017
Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases
Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaProminent cytologic atypiaMultiple squamous cell carcinomasCytologic atypiaSquamous proliferationTP53 mutationsDetectable TP53 mutationsLegs of womenFollicle-like structuresCell carcinomaHistopathologic findingsMultiple lesionsSCC lesionsHistopathologic analysisTP53 sequencingNumerous tumorsSmall seriesTP53 variantsClinical phenotypeKeratoacanthomaLesionsTumorsDifferent patientsAtypiaReactive phenomenon
2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHair follicle infundibulumFollicular invasionCell carcinomaMohs micrographic surgeryHair follicle epitheliumAdditional patientsIntraoperative pathologyOptimal therapyRetrospective reviewTreatment failureProspective evaluationSingle institutionHistopathologic assessmentMicrographic surgeryMost tumorsDeep invasionTreatment approachesPathology specimensFollicle epitheliumLower follicleSCCISSurgeryCarcinomaInvasion
2014
Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study
Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study. European Journal Of Cancer Prevention 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/cej.0000000000000037.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaCase-control studyCell carcinomaDermatopathology databaseOdds ratioRegular consumptionRisk of BCCMultivariate odds ratiosSquamous cell carcinomaUnconditional logistic regressionConfidence intervalsModest protective effectHot teaNon-Hispanic whitesPotential health benefitsEpidemiologic evidenceInverse associationProtective effectBiopsy siteAge 40Caffeinated coffeeSkin carcinogenesisBCC casesProtective role
2013
Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatment
2005
Mohs micrographic surgery: established uses and emerging trends.
Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaMohs micrographic surgeryCell carcinomaMicrographic surgeryCommon cutaneous neoplasmsConventional surgical excisionExtramammary Paget's diseaseMicrocystic adnexal carcinomaMerkel cell carcinomaCutaneous neoplasmsPaget's diseaseResidual tumorSurgical excisionAdnexal carcinomaCommon cancerCutaneous tumorsSurgical techniqueDermatofibrosarcoma protuberansCarcinomaDeep marginTissue conservationSurgeryTumorsDiseasePTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer
Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. British Journal Of Dermatology 2005, 152: 868-873. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Basal CellCarcinoma, Squamous CellCodonGenetic Predisposition to DiseaseGenotypeHair ColorHumansLoss of HeterozygosityNeoplasm ProteinsPatched ReceptorsPatched-1 ReceptorPilot ProjectsPolymerase Chain ReactionPolymorphism, Single NucleotideReceptors, Cell SurfaceSkin NeoplasmsSkin PigmentationConceptsPro/Pro genotypeNonmelanoma skin cancerBasal cell carcinomaPTCH tumor suppressor geneSquamous cell carcinomaAllele frequency variationAllelic loss studiesTumor suppressor genePro genotypeSingle nucleotide polymorphismsAllelic lossGenomic DNANonrandom lossSuppressor geneCell carcinomaSwedish patientsEpithelial cell cancersLight pigmentationSkin cancerNucleotide polymorphismsMultiple basal cell carcinomasPro/LeuHuman populationPTCH geneAllele frequencies
2000
The scientific basis of skin cancer
Leffell D. The scientific basis of skin cancer. Journal Of The American Academy Of Dermatology 2000, 42: s18-s22. PMID: 10607352, DOI: 10.1067/mjd.2000.103340.Peer-Reviewed Original Research
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMohs micrographic surgeryResidual tumorCell carcinomaMicrographic surgeryPatientsSurgeryCarcinomaTumors
1993
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-4220. PMID: 8483937, PMCID: PMC46477, DOI: 10.1073/pnas.90.9.4216.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaCell carcinomaSkin cancerPercent of tumorsSquamous cell carcinomaNonmelanoma skin cancerP53 tumor suppressor geneDipyrimidine sitesBCC developmentMutation hotspotsCancerTumor suppressor geneP53 genePoint mutationsAllelic lossCarcinomaTwo-thirdsSuppressor geneGenetic eventsSkinP53Such mutationsMutationsCarcinogenic mutationsTumors