Our research efforts cover a variety of topics that address critical societal needs. Cancer screening, treatment, and risk stratification options have expanded substantially in recent years. As clinicians and policy makers strive to understand and integrate newer cancer management modalities in a safe, effective, and efficient manner, they face several critical challenges. First, little is known about patient outcomes associated with the use of specific cancer screening tests and treatments in the context of their actual use in the population. Second, it is unclear whether the increasing costs of newer management approaches provide commensurate impact on patient health. A further understanding of care patterns, costs, and effectiveness is critical for guiding research, policy, and clinical care decisions.