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YCC Publications 2024

April 02, 2024

Recent publications by Yale Cancer Center members.


Cancer and incarceration: a call for action. Richman IB, Gross CP, Wang EA. Lancet Oncol. 2024 May;25(5):530-531.

Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes. Saliby RM, Labaki C, Jammihal TR, Xie W, Sun M, Shah V, Saad E, Kane MH, Kashima S, Sadak K, El Zarif T, Poduval D, Motzer RJ, Powles T, Rini BI, Albiges L, Pal SK, McGregor BA, McKay RR, Signoretti S, Van Allen EM, Shukla SA, Choueiri TK, Braun DA. Cancer Cell. 2024 May 13;42(5):732-735.

TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion? Ghosh S, Rothlin CV. Neuro Oncol. 2024 May 3;26(5):840-842

Approach to immunotherapy for HCC in the liver transplant population. Block PD, Strazzabosco M, Jaffe A. Clin Liver Dis (Hoboken). 2024 May 3;23(1):e0158.

Event-free survival by residual cancer burden with pembrolizumab in early-stage TNBC: exploratory analysis from KEYNOTE-522. MAPusztai L, Denkert C, O'Shaughnessy J, Cortes J, Dent R, McArthur H, Kümmel S, Bergh J, Park YH, Hui R, Harbeck N, Takahashi M, Untch M, Fasching PA, Cardoso F, Zhu Y, Pan W, Tryfonidis K, Schmid P. Ann Oncol. 2024 May;35(5):429-436.

Exploring new perspectives in immunology. Medzhitov R, Iwasaki A. Cell. 2024 Apr 25;187(9):2079-2094. doi: 10.1016/j.cell.2024.03.038. PMID: 38670066.

Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline Update. Gordan JD, Kennedy EB, Abou-Alfa GK, Beal E, Finn RS, Gade TP, Goff L, Gupta S, Guy J, Hoang HT, Iyer R, Jaiyesimi I, Jhawer M, Karippot A, Kaseb AO, Kelley RK, Kortmansky J, Leaf A, Remak WM, Sohal DPS, Taddei TH, Wilson Woods A, Yarchoan M, Rose MG. J Clin Oncol. 2024 May 20;42(15):1830-1850.

The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer. Van Schil PE, Asamura H, Nishimura KK, Rami-Porta R, Kim YT, Bertoglio P, Cangir AK, Donington J, Fang W, Giroux DJ, Lievens Y, Liu H, Lyons G, Sakai S, Travis WD, Ugalde P, Jeffrey Yang CF, Yotsukura M, Detterbeck F; Members of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Boards and Participating Institutions. J Thorac Oncol. 2024 May;19(5):749-765.

ARID1A in Gynecologic Precancers and Cancers. Morgan JE, Jaferi N, Shonibare Z, Huang GS. Reprod Sci. 2024 May 13.

Should the TNM Staging of NSCLC Evolve Beyond Anatomical Descriptors? Woodard GA, Dacic S. J Thorac Oncol. 2024 May;19(5):663-665

Digital Interventions to Support Lung Cancer Screening: A Systematic Review. Odole IP, Andersen M, Richman IB.. Am J Prev Med. 2024 May;66(5):899-908.

Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies. Hu R, Korutla L, Vallabhajosyula P. Ann Surg Oncol. 2024 May 16.

Melanoma tumour-infiltrating T-lymphocyte therapy heralds the era of cell-based immunotherapies for solid tumours. Talty R, Richmond R, Micevic G. Br J Dermatol. 2024 May 17;190(6):779-781.

Disparities in stage at diagnosis among breast cancer molecular subtypes in China. Zeng H, Wu S, Ma F, Ji JS, Lu L, Ran X, Shi J, Li D, An L, Zheng R, Zhang S, Chen W, Wei W, He Y, He J. Cancer Med. 2023 May;12(9):10865-10876.

The enduring neutrophil-stroma dance of multiple myeloma. Cerezo-Wallis D, Ballesteros I. Nat Immunol. 2024 May;25(5):731-732.


Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris PC, Pearson MJ, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely MD, Zhang Y, Zhang J, Ji L, Flies DB, Liu L, Langermann S, LaRochelle WJ, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper KA, Sanmamed MF, Chen L. Sci Immunol. 2024 Apr 26;9(94):eadh2334.

Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring. Sun J, Esplugues E, Bort A, Cardelo MP, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Nat Metab. 2024 Apr;6(4):741-763.

De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy. Yarbrough WG, Schrank TP, Burtness BA, Issaeva N. Viruses. 2024 Mar 29;16(4):536.

Real-world patterns and sequences of targeted therapy use in chronic lymphocytic leukemia and small lymphocytic lymphoma in the United States: a longitudinal study. Huntington SF, Cheng WY, Sarpong EM, Leng S, Farooqui MZH, Agu US, Catillon M, Lejeune D, Downes N, Matay L, Duh MS, De Nigris E. Leuk Lymphoma. 2024 May 2:1-11.

Immunometabolism of CD8+ T cell differentiation in cancer. Shi H, Chen S, Chi H. Trends Cancer. 2024 Apr 30:S2405-8033(24)00059-1. Epub ahead of print. PMID: 38693002.

Challenges in management of older patients with chronic myeloid leukemia. Stempel JM, Shallis RM, Wong R, Podoltsev NA. Leuk Lymphoma. 2024 Apr 23:1-14.

Area Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma. Rahman SN, Long JB, Westvold SJ, Leapman MS, Spees LP, Hurwitz ME, McManus HD, Gross CP, Wheeler SB, Dinan MA JAMA Netw Open. 2024 Apr 1;7(4):e248747.

Cost-effectiveness of adding quizartinib to induction chemotherapy for patients with FLT3-mutant acute myeloid leukemia. Bewersdorf JP, Patel KK, Shallis RM, Podoltsev NA, Kewan T, Stempel J, Mendez L, Stahl M, Stein EM, Huntington SF, Goshua G, Zeidan AM. Leuk Lymphoma. 2024 Apr 22:1-9.

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Xin T, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S, Greco V. Nat Cell Biol. 2024 Apr 30.

Trends and predictors of Quality of Life in lung cancer survivors. Bade BC, Zhao J, Li F, Tanoue L, Lazowski H, Alfano CM, Silvestri GA, Irwin ML. Lung Cancer. 2024 Apr 16;191:107793.

A retrospective cohort study describing chemotherapy-induced peripheral neuropathy in Non-Hodgkin lymphoma patients treated with EPOCH ± R: does HIV status matter? McNally GA, Aossey CM, Wiczer T, Sinnott LT, Lustberg M, Baiocchi RA, Lustberg M. Leuk Lymphoma. 2024 Apr 22:1-7.


A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing. Loeb S, Keith SW, Cheng HH, Leader AE, Gross L, Sanchez Nolasco T, Byrne N, Hartman R, Brown LH, Pieczonka CM, Gomella LG, Kelly WK, Lallas CD, Handley N, Mille PJ, Mark JR, Brown GA, Chopra S, McClellan A, Wise DR, Hollifield L, Giri VN. JCO Precis Oncol. 2024 Mar;8:e2300552.

De-Escalated Therapy and Early Treatment of Recurrences in HPV-Associated Head and Neck Cancer: The Potential for Biomarkers to Revolutionize Personalized Therapy. Yarbrough WG, Schrank TP, Burtness BA, Issaeva N. Viruses. 2024 Mar 29;16(4):536.

Estimating Breast Cancer Overdiagnosis After Screening Mammography Among Older Women in the United States. Richman IB, Gross CP. Ann Intern Med. 2024 Mar;177(3):403-404.

De novo-designed transmembrane proteins bind and regulate a cytokine receptor. Mravic M, He L, Kratochvil HT, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF. Nat Chem Biol. 2024 Mar 13. doi: 10.1038/s41589-024-01562-z. Epub ahead of print.

Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Puklin LS, Ferrucci LM, Harrigan M, McGowan C, Zupa M, Cartmel B, Li FY, Ligibel JA, Spiegelman D, Sharifi M, Sanft T, Irwin ML. Cancer. 2024 Mar 12. doi: 10.1002/cncr.35280. Epub ahead of print.

Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning-Generated Biomarkers. Haider SP, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann BH, Judson BL, Prasad ML, Burtness B, Aboian M, Canis M, Reichel CA, Baumeister P, Payabvash S. J Nucl Med. 2024 Mar 21:jnumed.123.266637. Online ahead of print.

Oncology hospitalist impact on hospice utilization. Prsic E, Morris JC, Adelson KB, Parker NA, Gombos EA, Kottarathara MJ, Novosel M, Castillo L, Gould Rothberg BE. Cancer. 2023 Dec 1;129(23):3797-3804.

A Comparison Between In-Person and Virtual Communication Skills OSCE for Medical Students. Choi A, Murtha TD, Morrison LJ, Talwalkar JS. J Med Educ Curric Dev. 2024 Mar 25;11:23821205241241375.

The Right Dose: Results of a Patient Advocate-Led Survey of Individuals With Metastatic Breast Cancer Regarding Treatment-Related Side Effects and Views About Dosage Assessment to Optimize Quality of Life. Loeser A, Kim JS, Peppercorn J, Burkard ME, Niemierko A, Juric D, Kalinsky K, Rugo H, Glenn L, Hodgdon C, Maues J, Johnson S, Padron N, Parekh K, Lustberg M, Bardia A. JCO Oncol Pract. 2024 Mar 22:OP2300539. Epub ahead of print.

An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers. Xirou V, Moutafi M, Bai Y, Nwe Aung T, Burela S, Liu M, Kimple RJ, Shabbir Ahmed F, Schultz B, Flieder D, Connolly DC, Psyrri A, Burtness B, Rimm DL. Oral Oncol. 2024 Mar 27;152:106750.

Impact of the Breast Cancer Index for Extended Endocrine Decision-Making: First Results of the Prospective BCI Registry Study. Sanft TB, Wong J, O'Neal B, Siuliukina N, Jankowitz RC, Pegram MD, Fox JR, Zhang Y, Treuner K, O'Shaughnessy JA. J Natl Compr Canc Netw. 2024 Mar 4;22(2):99-107.

Renovating the Commission on Cancer's Quality Measure Portfolio. Boffa DJ, Lum SS, Palis B, McCabe R, Park KU, Siddiqui MM, Facktor M, Mullet T, Nelson H. Ann Surg. 2024 Mar 28. Online ahead of print.

EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Hu Z, Chen PH, Li W, Krone M, Zheng S, Saarbach J, Velasco IU, Hines J, Liu Y, Crews CM. Sci Adv. 2024 Mar 29;10(13):eadj7251.

How Far We've Come. Sznol M, Weber JS. Cancer J. 2024 Mar-Apr 01;30(2):47.

Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma. Su DG, Schoenfeld DA, Ibrahim W, Cabrejo R, Djureinovic D, Baumann R, Rimm DL, Khan SA, Halaban R, Kluger HM, Olino K, Galan A, Clune J. J Immunother Cancer. 2024 Mar 21;12(3):e008646.

Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape. Boddu PC, Gupta AK, Roy R, De La Peña Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Mol Cell. 2024 Mar 22:S1097-2765(24)00175-8. Online ahead of print

Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Tabor JK, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal MI, Yalcin K, Morales-Valero SF, Marianayagam N, Alanya H, Elsamadicy AA, Millares Chavez MA, Aguilera SM, Mishra-Gorur K, McGuone D, Fulbright RK, Jin L, Erson-Omay EZ, Günel M, Moliterno J. J Neurosurg. 2024 Mar 22:1-9.

Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study. Nassar AH, El-Am E, Denu R, Abou Alaiwi S, El Zarif T, Macaron W, Abdel-Wahab N, Desai A, Smith C, Parikh K, Abbasi M, Bou Farhat E, Williams JM, Collins JD, Al-Hader A, McKay RR, Malvar C, Sabra M, Zhong C, El Alam R, Chehab O, Lima J, Phan M, Dalla Pria HF, Trevino A, Neilan TG, Kwan JM, Ravi V, Deshpande H, Demetri G, Choueiri TK, Naqash AR. JACC CardioOncol. 2024 Jan 16;6(1):71-79.

Clinical activity, pharmacokinetics, and pharmacodynamics of oral hypomethylating agents for myelodysplastic syndromes/neoplasms and acute myeloid leukemia: A multidisciplinary review. Haumschild R, Kennerly-Shah J, Barbarotta L, Zeidan AM. J Oncol Pharm Pract. 2024 Mar 21:10781552241238979.

Updated Analysis of Comparative Toxicity of Proton and Photon Radiation for Prostate Cancer. Yu JB, DeStephano DM, Jeffers B, Horowitz DP, Soulos PR, Gross CP, Cheng SK. J Clin Oncol. 2024 Mar 20:JCO2301604.


JAMA Oncology kicked off 2024 for YCC with Immunotherapy Initiation at the End of Life in Patients With Metastatic Cancer in the US. The study’s senior author, Dr. Sajid Khan, is section chief of hepato-pancreato-biliary (HPB) and mixed tumors at Yale School of Medicine. The study drew headlines on OncLive, Medscape, the Cancer Network and others and a JAMA Oncology podcast.

In other publication news, a chance encounter at the recent Stand Up To Cancer (SU2C) meeting in San Diego led to Yale’s Alessandro Santin, MD, learning he and the gynecologic oncology research/clinical team had been named in an article in a July 2023 issue of Medicine. The article, Bibliometric and visualized analysis of the top-100 highly cited articles on immunotherapy for endometrial cancer, concluded: “The attention of researchers from different countries to EC immunotherapy, especially immunosuppressants, has brought a breakthrough in this field.” Yale was singled out for ranking first, followed by MSKCC, for citations in endometrial cancer immunotherapy research worldwide in the period studied.

EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth. Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna RS, Traina KA, Robles-Oteíza C, Ayeni D, Kwong EM, Levy S, Globig AM, Nobari MM, Cheng GZ, Leibel SL, Homer RJ, Shaw RJ, Metallo CM, Politi K, Kaech SM. Cancer Discov. 2024 Jan 25:OF1-OF22

Neutrophils in Physiology and Pathology Aroca-Crevillén A, Vicanolo T, Ovadia S, Hidalgo A. Annu Rev Pathol. 2024 Jan 24;19:227-259

Transmembrane pH gradient imaging in rodent glioma models Mishra SK, Santana JG, Mihailovic J, Hyder F, Coman D. NMR Biomed. 2024 Jan 23:e5102

Cell surface RNAs control neutrophil recruitment Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan SA, Kumar P, Hidalgo A, Wu D, Lu J. Cell. 2024 Jan 17:S0092-8674(23)01443-5

Consolidation Osimertinib versus Durvalumab versus Observation following Concurrent Chemoradiation in Unresectable EGFR-Mutant Non-Small-Cell Lung Cancer: A Multicenter Retrospective Cohort Study. Nassar AH, Kim SY, Aredo JV, Feng J, Shepherd F, Xu C, Kaldas D, Gray JE, Dilling TJ, Neal JW, Wakelee HA, Liu Y, Lin SH, Abuali T, Amini A, Nie Y, Patil T, Lobachov A, Bar J, Fitzgerald B, Fujiwara Y, Marron TU, Thummalapalli R, Yu H, Owen DH, Sharp J, Farid S, Rocha P, Arriola E, D'Aiello A, Cheng H, Whitaker R, Parikh K, Ashara Y, Chen L, Sankar K, Harris JP, Nagasaka M, Ayanambakkam A, Manana AI, Ragavan M, Lin JJ, Piotrowska Z, Wilgucki M, Reuss J, Luders H, Grohe C, Espinar JB, Feiner E, Punekar SR, Gupta S, Leal T, Kwiatkowski DJ, Mak RH, Adib E, Naqash AR, Goldberg SB. J Thorac Oncol. 2024 Jan 24:S1556-0864(24)00032-7.

Sensitizing the Efficiency of ICIs by Neoantigen mRNA Vaccines for HCC Treatment Han R, Wang Y, Lu L. Pharmaceutics. 2023 Dec 29;16(1):59

Endoscopic Ultrasound in Cancer Staging Aslanian HR, Muniraj T, Nagar A, Parsons D. Gastrointest Endosc Clin N Am. 2024 Jan; 34(1):37-49.

Multi-Institutional Outcomes of Dorsal Onlay Buccal Mucosal Graft Urethroplasty in Patients With Postprostatectomy, Postradiation Anastomotic Stenosis. Sterling J, Simhan J, Flynn BJ, Rusilko P, Franca WA, Ramirez EA, Angulo JC, Martins FE, Patel HV, Higgins M, Swerdloff D, Nikolavsky D. J Urol. 2024 Jan 26:101097JU0000000000003848

Evaluating an Enterprise-Wide Initiative to enhance healthcare coordination for rural women Veterans using the RE-AIM framework. Relyea MR, Kinney RL, DeRycke EC, Haskell S, Mattocks KM, Bastian LA. Front Health Serv. 2024 Jan 12;3:1237701

Medical Physics Training and Education: Learning From the Past and Looking to the Future. Bertholet J, Al Hallaq H, Toma-Dasu I, Ingledew PA, Carlson DJ. Int J Radiat Oncol Biol Phys. 2023 Dec 1;117(5):1039-1044.

Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery H. G. McDonald, D. M. Kerekes, J. Kim and S. A. Khan. Surgical Oncology Clinics of North America 2024

Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial. Lustberg M, Fan-Havard P, Wong FL, Hill K, Phelps MA, Herrera KW, Tsai NC, Synold T, Feng Y, Kalu C, Sedrak MS, Yee LD. Breast Cancer Res Treat. 2024 Jan 27.

Submitted by Naedine Hazell on April 01, 2024