Peter Smith, DVM, DACLAM
Professor of Comparative MedicineDownloadHi-Res Photo
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Appointments
Comparative Medicine
Primary
Additional Titles
Director, Residency Training Program
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Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Additional Titles
Director, Residency Training Program
Contact Info
Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Additional Titles
Director, Residency Training Program
Contact Info
Yale School of Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
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Titles
Professor of Comparative Medicine
Director, Residency Training Program
Appointments
Comparative Medicine
ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Comparative Medicine
- Yale Ventures
Education & Training
- DVM
- Michigan State University (1996)
- Postdoctoral Fellow
- University of Michigan
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Peter Smith's published research.
Publications Timeline
A big-picture view of Peter Smith's research output by year.
Ann Haberman, PhD
Antariksh Tyagi, PhD
Brent Vander Wyk, PhD
Caroline Zeiss, DACVP, DACLAM
Emanuela Bruscia, PhD
George Tellides, MD, PhD
22Publications
1,607Citations
Publications
2025
Environmental Enrichment Attenuates Reproductive Adversity in a Mouse Model of Parkinson Disease.
Walsh C, Johnson L, Cirillo P, Smith P, Wilson S. Environmental Enrichment Attenuates Reproductive Adversity in a Mouse Model of Parkinson Disease. Journal Of The American Association For Laboratory Animal Science 2025, 64: 58-63. PMID: 40035270, PMCID: PMC11808379, DOI: 10.30802/aalas-jaalas-24-000032.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPercent survivalReproductive parametersEnvironmental enrichmentModel of Parkinson's diseaseMouse modelDam weightBreeding efficiencySpecies-specific behaviorsInterlitter intervalAnimal's natural environmentMouse model of Parkinson's diseaseSurvival of pupsEnvironmental stimuliParkinsonism phenotypeReproductive adversityParkinson's diseaseProductivity indexGenetic predispositionChronic isolationEarly expressionEnrichmentMicePupsBreedingDisease
2024
Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering
Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon M, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs D, Tellides G, Anegon I, Pober J, Liu P, Qyang Y. Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Acta Biomaterialia 2024, 193: 171-184. PMID: 39681154, PMCID: PMC12212065, DOI: 10.1016/j.actbio.2024.12.033.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsVascular tissue engineeringPig induced pluripotent stem cellsPluripotent stem cellsEndothelial cellsLarge animal modelStem cellsAnimal modelsTissue engineeringInferior vena cava graftHuman induced pluripotent stem cellsEffective differentiation protocolsPreclinical large animal modelExpression of endothelial markersCell-based therapiesExtensive preclinical testingPig endothelial cellsFunctional endothelial cellsIn vivo functional studiesTreatment of cardiovascular diseasesVascular endothelial cellsTissue engineering therapiesTransplant therapeuticsEfficacy of tissueImmunodeficient ratsPrior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters
Di Pietro C, Haberman A, Lindenbach B, Smith P, Bruscia E, Allore H, Vander Wyk B, Tyagi A, Zeiss C. Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters. Viruses 2024, 16: 246. PMID: 38400021, PMCID: PMC10891789, DOI: 10.3390/v16020246.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransient gene expressionSARS-CoV-2Viral replication pathwayReplication pathwayAntiviral pathwaysEndemism patternsUpregulation of innateGene expressionQuantitative RT-PCRMitigated weight lossDual-infected animalsSARS-CoV-2 viral loadSARS-CoV-2 infectionSyrian hamstersSeasonal infection ratesSARS-CoV-2 inoculationLungs of animalsIndividual virusesSARS-CoV-2 diseaseUpper respiratory tractH1N1 infectionRT-PCRBronchoalveolar lavageViral loadCytokine levels
2023
Effect of Cage Change Frequency on Perinatal Mortality in C57BL/6J Mice.
Wharton K, Walsh C, Bauer-Pisani T, Smith P, Wilson S. Effect of Cage Change Frequency on Perinatal Mortality in C57BL/6J Mice. Journal Of The American Association For Laboratory Animal Science 2023, 63: 148-153. PMID: 38061769, PMCID: PMC11022952, DOI: 10.30802/aalas-jaalas-23-000055.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsSystematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds
Li Z, Wang Z, Chen Z, Voegeli H, Lichtman J, Smith P, Liu J, DeWan A, Hoh J. Systematically identifying genetic signatures including novel SNP-clusters, nonsense variants, frame-shift INDELs, and long STR expansions that potentially link to unknown phenotypes existing in dog breeds. BMC Genomics 2023, 24: 302. PMID: 37277710, PMCID: PMC10240460, DOI: 10.1186/s12864-023-09390-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBreed-specific traitsGenetic signaturesShort tandem repeatsSingle nucleotide polymorphismsSNP clustersGenome-wide association studiesDog breedsNovel single nucleotide polymorphismsWhole-genome sequencing technologyFrame-shifting indelsNovel genetic signaturesNonsense variantGenomic structureUnknown phenotypeSTR expansionsGenomic regionsPhenotypic traitsSequencing technologiesGenetic insightsAssociation studiesTandem repeatsDisease predispositionSequence mapsNucleotide polymorphismsTraitsEffects of Housing Density on Reproductive Performance, Intracage Ammonia, and Welfare of Mice Continuously Housed as Breeders in Standard Mouse and Rat Caging.
Cho E, Walsh C, D'Angelo-Gavrish N, Wilson S, Cirillo P, Smith P. Effects of Housing Density on Reproductive Performance, Intracage Ammonia, and Welfare of Mice Continuously Housed as Breeders in Standard Mouse and Rat Caging. Journal Of The American Association For Laboratory Animal Science 2023, 62: 116-122. PMID: 36878483, PMCID: PMC10078924, DOI: 10.30802/aalas-jaalas-22-000069.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBreeding triosReproductive performanceFecal corticosterone levelsAmmonia concentrationRat cagesReproductive performance dataParameters of reproductive performanceEffect of housing densityMouse cagesBreeding configurationCage densityDaily health checksContinuous housingBreedingCorticosterone levelsCage changeCage sizePairs breedingBreeding pairsPup survival rateCageProductivity indexMouse welfareTriosIntracageEffect of Cage Change Frequency on Perinatal Mortality in C57BL/6J Mice
Wharton K, Walsh C, Bauer-Pisani T, Smith P, Wilson S. Effect of Cage Change Frequency on Perinatal Mortality in C57BL/6J Mice. Journal Of The American Association For Laboratory Animal Science 2023 DOI: 10.30802/aalas-jaalas-23-000055fs1.Peer-Reviewed Original Research
2022
Salted roads lead to oedema and reduced locomotor function in amphibian populations
Brady S, Goedert D, Frymus L, Zamora‐Camacho F, Smith P, Zeiss C, Comas M, Abbott T, Basu S, DeAndressi J, Forgione M, Maloney M, Priester J, Senturk F, Szeligowski R, Tucker A, Zhang M, Calsbeek R. Salted roads lead to oedema and reduced locomotor function in amphibian populations. Freshwater Biology 2022, 67: 1150-1161. DOI: 10.1111/fwb.13907.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAmphibian populationsWood frogsTemperate zoneRunoff pollutionFreshwater habitatsPotential fitness costsAdult wood frogsPresence of roadsInfluence of roadsCentral New EnglandConsequence of roadHabitat conversionNatural populationsNorthern populationsPopulation declineNortherly populationsBreeding pondsFitness costsSalt runoffHuman activitiesRoad saltEnvironmental changesBreeding seasonEnergetic demandsDisease emergence
2019
Concentration-dependent Toxicity after Subcutaneous Administration of Meloxicam to C57BL/6N Mice (Mus musculus).
Sarfaty AE, Zeiss CJ, Willis AD, Harris JM, Smith PC. Concentration-dependent Toxicity after Subcutaneous Administration of Meloxicam to C57BL/6N Mice (Mus musculus). Journal Of The American Association For Laboratory Animal Science 2019, 58: 802-809. PMID: 31540585, PMCID: PMC6926403, DOI: 10.30802/aalas-jaalas-19-000037.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsInjection siteFull-thickness epidermal necrosisPost-operative analgesiaFemale C57BL/6N miceMouse Grimace ScaleYoung adult malesNSAID dosesGastrointestinal ulcerationCavitary lesionsC57BL/6N miceEpidermal necrosisKidney lesionsNSAID toxicityGastric ulcerationSaline controlsSubcutaneous administrationPathologic lesionsRelevant pathologyMinimal dosesLesionsSevere pathologySkin pathologyMiceSeventh dayMeloxicam
2017
Comparison of 6 Injectable Anesthetic Regimens and Isoflurane in Gray Short-tailed Opossums (Monodelphis domestica).
Barnett G, Barnett I, Wilson S, Smith P. Comparison of 6 Injectable Anesthetic Regimens and Isoflurane in Gray Short-tailed Opossums (Monodelphis domestica). Journal Of The American Association For Laboratory Animal Science 2017, 56: 544-549. PMID: 28903826, PMCID: PMC5605179.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSurgical plane of anesthesiaInjectable anesthetic combinationsInjectable anesthetic regimensSurgical planePlane of anesthesiaSurgical anesthesiaAnesthetic combinationXylazinePrecision vaporizerGray short-tailed opossumInhalation anesthesiaLight anesthesiaAnesthetic regimensOpossumEffects of anesthesiaAnimalsIsofluraneKetamineInjection combinationsLow dosesDomesticaLow dose of ketamineAnesthetic complicationsDose of ketamineDexmedetomidine
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PO Box 208016
New Haven, CT 06520-8016
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