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Stem cells have reshaped modern biology. At Yale School of Medicine, researchers are uncovering how they function and how to harness them for human health.

Researchers in the Vascular Biology and Therapeutics Program are working to address chronic inflammation, heart disease, and more.

Growing evidence from Yale suggests that regular physical activity can help lower cancer risk and improve outcomes. Experts emphasize that while exercise isn’t a cure-all, even moderate activity may offer meaningful benefits.

David A. Alagpulinsa, PhD, assistant professor in the Department of Comparative Medicine, has received a New Investigator Gateway Award for Collaborative T1D Research from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and two Breakthrough T1D Innovative Awards.

Calorie restriction lowers C3, an immune protein tied to aging and inflammation, improving health without requiring weight loss.

Yale investigators, in collaboration with a team of international scientists, have nearly doubled the known genetic landscape of endometriosis, a chronic and often debilitating inflammatory disease affecting approximately 10% of women worldwide. Renato Polimanti, PhD, MSc, is senior author of the paper, published in Nature Genetics.

Scientists found a potential target for achieving the healthy longevity that can come with calorie restriction, without the negative effects it can have on the immune system.

New research suggests that cognitive traits observed in some individuals with type 1 diabetes may share underlying biological origins with the disease itself.

“One of the paper’s most important and unexpected findings was showing that one’s perception of connectedness to another person is directly related to the activity in these specific regions of the brain,” Hirsch, PhD, said.