Huabing Li, PhD
Assistant Professor AdjunctCards
About
Research
Publications
2025
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
Li H, Cai X, Xu C, Yang X, Song X, Kong Y, Yang M, Wu Q, Zheng S, Shao Y, Wang P, Zhou J, Li H. RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease. Cell Discovery 2025, 11: 19. PMID: 40038243, PMCID: PMC11880361, DOI: 10.1038/s41421-025-00781-5.Peer-Reviewed Original ResearchAccelerated rate of apoptosisPost-transcriptional gene regulationBcl2-associated athanogene 3N-acetyltransferase 10Apoptosis-related genesUpregulation of apoptosis-related genesAcetyltransferase NAT10T cell developmentRate of apoptosisGene regulationApoptotic pathwayAc4C modificationN4-acetylcytidineCD4+ T cellsAcetylation modificationNAT10Inflammatory bowel diseaseMRNA stabilityNAT10 expressionDiminished stabilityT cellsN-acetyltransferaseRNAPathogensNaive CD4+ T cellsAcute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.
Hu X, He Y, Li S, Jiang Y, Yu R, Wu Y, Fu X, Song Y, Lin C, Shi J, Li H, Gao Y. Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. Development 2025, 152 PMID: 39817838, DOI: 10.1242/dev.204226.Peer-Reviewed Original ResearchFetal hematopoiesisMegakaryocyte-erythroid progenitorsAcute inflammationInterferon-stimulated genesDouble-stranded RNAMegakaryocyte maturationPlatelet productionImpaired platelet productionFormation of double-stranded RNADownstream interferon-stimulated genesCell fate determinationRNA m6A modificationPhosphorylation of STAT1Hematopoietic progenitorsMegakaryocyte progenitorsHematopoietic cellsM6A methyltransferase METTL3Hematopoietic developmentGene expression analysisImmune responseMegakaryopoiesisHematopoiesisInflammationFate determinationIGF1 expressiontRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells
Miao S, Li H, Song X, Liu Y, Wang G, Kan C, Ye Y, Liu R, Li H. tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. Journal Of Experimental Medicine 2025, 222: e20240559. PMID: 39873720, PMCID: PMC11774205, DOI: 10.1084/jem.20240559.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsTumor-killing functionTransfer RNARegulating cholesterol biosynthesisAntitumor immunityCapacity of CD8+ T cellsActivation of CD8+ T cellsCholesterol biosynthesisM1A modificationTumor-killing capacityAntitumor responseATP citrate lyaseCancer immunotherapyCD8Effector functionsMetabolic reprogrammingProtein translationBiosynthetic demandsCitrate lyaseIn vitro assaysIn vivoPosttranscriptional mechanismsRegulatory checkpointsBiosynthesisMETTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell
Ding C, Yang X, Liu H, Roulis M, Chen H, Chen Y, Xu H, Gao Y, Zhong J, Li H, Ye Y, Cai W, Hu W, Wang Z. METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell. Journal Of Molecular Cell Biology 2025, mjae060. PMID: 39762134, DOI: 10.1093/jmcb/mjae060.Peer-Reviewed Original ResearchSelf-renewalStem cellsMaturation of goblet cellsDifferentiation of Lgr5Ulcerative colitisHomeostasis of intestinal epitheliumColonic stem cellsGoblet cellsSpontaneous inflammationIntestinal dysplasiaColonic mucosaUC treatmentLgr5Epithelium integrityDepletion of METTL3Intestinal epitheliumTherapeutic targetInflammationDifferentiation capacityMETTL3 expressionUC samplesMETTL3 levelsExpression levelsM6A methylationCells
2024
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Chen Y, Chen B, Li J, Li H, Wang G, Cai X, Zhang Q, Liu X, Kan C, Wang L, Wang Z, Li H. Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway. Cellular & Molecular Immunology 2024, 21: 1522-1534. PMID: 39537902, PMCID: PMC11607066, DOI: 10.1038/s41423-024-01237-8.Peer-Reviewed Original ResearchThe physiological and pathological roles of RNA modifications in T cells
Deng Y, Zhou J, Li H. The physiological and pathological roles of RNA modifications in T cells. Cell Chemical Biology 2024, 31: 1578-1592. PMID: 38986618, DOI: 10.1016/j.chembiol.2024.06.003.Peer-Reviewed Original ResearchRNA modificationsDynamic chemical modificationsInternal RNA modificationFunctions of mammalian cellsT cell developmentPathological roleRNA transcriptsCellular stimuliMammalian cellsRNA moleculesPost-transcriptionallyT cell biologyT cell survivalT cellsCell developmentCell survivalCell biologyRNAT cell-based immunotherapyCell-based immunotherapyT cell immunityAdaptive immunityCellsDifferentiationCell immunity
2023
Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue
López A, Ko E, Huang S, Pacella G, Kuprasertkul N, D’souza C, Hueros R, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li H, Seykora J, Liu K, Capell B. Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Science Advances 2023, 9: eadg5234. PMID: 37656787, PMCID: PMC10854438, DOI: 10.1126/sciadv.adg5234.Peer-Reviewed Original ResearchConceptsSomatic tissuesMessenger RNALayer of gene regulationHistone modifying enzymesImpaired cell adhesionChromatin modifiersGene regulationAbundant modificationGene expression abnormalitiesHistone modifiersSelf-renewalMethyltransferase-like protein 3Gross phenotypic abnormalitiesModifying enzymesN6</i>-methyladenosineEpithelial developmentCell adhesionPhenotypic abnormalitiesHair follicle morphogenesisProgenitors in vivoProtein 3Expression abnormalitiesOral ulcersEpithelial tissuesFollicle morphogenesis
2022
RNA methylation in immune cells
Chen Y, Oh M, Flavell R, Li H. RNA methylation in immune cells. Advances In Immunology 2022, 155: 39-94. PMID: 36357012, DOI: 10.1016/bs.ai.2022.08.002.Peer-Reviewed Original ResearchDiverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response
Hu Q, Xu T, Zhang M, Zhang H, Liu Y, Li H, Chen C, Zheng J, Zhang Z, Li F, Shen N, Zhang W, Melnick A, Huang C. Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response. Cell Reports 2022, 40: 111035. PMID: 35793628, PMCID: PMC9550188, DOI: 10.1016/j.celrep.2022.111035.Peer-Reviewed Original ResearchConceptsBach2 proteinCell fateActivated B cellsMemory B cellsB cellsCell fate choiceDetermines cell fateCell fate outcomesRapamycin complex 1B cell fateEffector cellsGerminal centre B cell fatePivotal transcription factorB cell receptor affinityEarly B cell responsesTranscription factorsDependent translationB cell responsesPrimary humoral responseGC fateMechanistic targetHumoral responseProteinPlasma cellsDifferential dynamicsDENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications 2022, 13: 2059. PMID: 35440133, PMCID: PMC9018773, DOI: 10.1038/s41467-022-29754-y.Peer-Reviewed Original ResearchConceptsPD-L1 expressionTumor immune evasionImmune evasionReduced PD-L1 expressionDeath ligand 1Tumor-killing activityT cellsTherapeutic targetTumor growthCancer cellsCRISPR/Cas9 screeningLigand 1Cell homeostasisKinase 2ExpressionEvasionCD8ImmunotherapyCellsIFNγDysfunctionRBP dysfunctionTumorsCancer
Get In Touch
Contacts
Email