Ehimen Aneni, MD, MPH, FACC
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
Appointments
About
Titles
Assistant Professor of Medicine (Cardiovascular Medicine)
Biography
My overarching interests are in the promotion of cardiometabolic health in diverse populations through understanding the relationships between cardiovascular diseases (CVDs) and metabolic risk factors. My research is focused on the intersection between obstructive sleep apnea (OSA) and CVD with a sub-focus on elucidating mechanisms of CVDs in OSA. Over the last 3 years, my work has focused on improving our understanding of the role of OSA in the occurrence, severity, and outcomes of cardiovascular diseases (CVDs). I have recently uncovered a strong association between abnormal myocardial flow reserve (a reduction in the capacity of the heart to increase its blood flow in proportion to its demands) and severe obstructive sleep apnea. Abnormal myocardial flow reserve may be a marker of disease of the small blood vessels of the heart (coronary microvascular dysfunction). My work has been presented at national conferences such as the Scientific Sessions of the American College of Cardiology and the American Heart Association. The findings of my research are published in major peer-reviewed scientific journals such as JACC, JACC Cardiovascular Imaging, Circulation Quality of Care and Cardiovascular Outcomes, JAHA, and Mayo Clinic Proceedings.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Clinical Fellow
- Yale University School of Medicine & Yale-New Haven Hospital (2021)
- Resident
- Mount Sinai Medical Center (2018)
- Postdoctoral Fellow
- Baptist Health South Florida (2015)
- MPH
- Boston University, Epidemiology & Global Health (2012)
- MD
- University of Ibadan, Medicine (2004)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Erica Spatz, MD, MHS
Albert Sinusas, MD
Edward J Miller, MD, PhD
Henry Yaggi, MD, MPH
Stephanie Thorn, MSc, PhD
Attila Feher, MD, PhD
Publications
Featured Publications
Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population
Aneni E, Osondu C, Joseph J, Saeed G, Valero-Elizondo J, Veledar E, Nasir K. Habitual sleep duration and its relationship with cardiovascular health, healthcare costs, and resource utilization in a working population. Sleep Health 2022, 9: 77-85. PMID: 36371382, PMCID: PMC9991949, DOI: 10.1016/j.sleh.2022.10.001.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCardiovascular healthHabitual sleep durationSleep durationHealthcare expendituresHealthcare costsOptimal cardiovascular healthIdeal cardiovascular healthBaptist Health South FloridaHealthcare resource utilizationBody mass indexBetter cardiovascular healthMedical claims dataHours of sleepLower healthcare expendituresCVH metricsMore hoursBlood pressureMass indexMean ageEmergency roomCardiovascular diseaseHigher oddsHispanic ethnicityPhysical activityClaims dataLipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesThe relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databasesEstimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis
Aneni EC, Crippa A, Osondu CU, Valero‐Elizondo J, Younus A, Nasir K, Veledar E. Estimates of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis. Journal Of The American Heart Association 2017, 6: e006904. PMID: 29269350, PMCID: PMC5779012, DOI: 10.1161/jaha.117.006904.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdeal cardiovascular healthIdeal CVH metricsPooled hazard ratioCVH metricsCardiovascular healthMortality benefitHazard ratioCardiovascular disease-related mortalityDose–response meta analysisStrong public health messageIdeal cardiovascular health metricsSubstantial mortality benefitCardiovascular health metricsCardiovascular disease mortalityLinear dose-response relationshipDisease-related mortalityPublic health messagesHazard ratio estimatesDose-response relationshipUnit increaseWeb of ScienceCause mortalityInternet literature searchDisease mortalityCardiovascular diseaseA Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities
Aneni EC, Roberson LL, Maziak W, Agatston AS, Feldman T, Rouseff M, Tran TH, Blumenthal RS, Blaha MJ, Blankstein R, Al-Mallah MH, Budoff MJ, Nasir K. A Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities. PLOS ONE 2014, 9: e83594. PMID: 24421894, PMCID: PMC3885454, DOI: 10.1371/journal.pone.0083594.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInternet-based programCardiovascular wellnessSystematic reviewCardiovascular disease risk managementCardiovascular health outcomesInclusion/exclusion criteriaPhysical activity outcomesSpecific disease entityWeb of ScienceCV healthRandomized trialsCochrane LibraryBlood glucoseDisease entityDisease risk managementPhysical activityExclusion criteriaRisk populationsHealth outcomesWellness interventionsPrevention programsActivity outcomesIntervention typeWellness approachBlue-collar workersThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAtherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea
Walia H, Khosla A, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Nasir K. Atherosclerotic plaque in individuals without known cardiovascular disease but with established obstructive sleep apnea and at high risk of obstructive sleep apnea. American Journal Of Preventive Cardiology 2023, 14: 100497. PMID: 37131984, PMCID: PMC10149201, DOI: 10.1016/j.ajpc.2023.100497.Peer-Reviewed Original ResearchCitationsAltmetricConceptsObstructive sleep apneaCoronary plaquesHigh riskSleep apneaLower riskBerlin questionnaireRisk factorsCT angiographySignificant associationMultivariable logistic regression analysisCardiovascular risk factorsCVD risk factorsLarge U.S. cohortCoronary CT angiographyLogistic regression analysisPopulation-based sampleComposition of plaquesLogistic regression modelsOSA cohortOSA presenceCoronary atherosclerosisOSA severityOSA categoriesSubgroup analysisCardiovascular diseaseThe risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study
Aneni E, Bittencourt M, Teng C, Cainzos-Achirica M, Osondu C, Soliman A, Al-Mallah M, Buddoff M, Parise E, Santos R, Nasir K. The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study. American Journal Of Preventive Cardiology 2020, 4: 100097. PMID: 34327473, PMCID: PMC8315654, DOI: 10.1016/j.ajpc.2020.100097.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLean non-alcoholic fatty liver diseaseNon-alcoholic fatty liver diseaseFatty liver diseaseAlcohol Use Disorders Identification TestLean individualsAtherogenic dyslipidemiaElevated glucoseElevated BPLiver diseaseFatty liverCardiovascular risk stratificationYoung asymptomatic individualsHealth promotion evaluationDisorders Identification TestAppropriate preventive measuresMedian followNAFLD individualsCardiometabolic consequencesCardiometabolic disordersRisk stratificationAsymptomatic individualsHigh riskBlood samplesAnthropometric measuresPopulation cohortBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2024
Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Khosla A, Nasir K, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Walia H. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study. Journal Of Clinical Sleep Medicine 2024 PMID: 38975989, DOI: 10.5664/jcsm.11274.Peer-Reviewed Original ResearchConceptsHigh risk of obstructive sleep apneaRisk of obstructive sleep apneaObstructive sleep apneaHs-CRPCardiovascular disease risk factorsFree of cardiovascular diseaseInflammatory markersHigh riskCardiovascular diseaseIL-6Sleep apneaLow risk of obstructive sleep apneaTNF-aObstructive sleep apnea screeningLow riskRisk factorsLevels of inflammatory markersLevels of hs-CRPTNF-a levelsCVD-free participantsHeart StudyBerlin questionnaireIndividuals free of cardiovascular diseaseSubclinical inflammationPoisson regression analysis
Academic Achievements and Community Involvement
activity American College of Cardiology
Professional OrganizationsFellowDetails2023 - Presentactivity European Heart Journal
Peer Review Groups and Grant Study SectionsReviewerDetails2022 - Presenthonor Doris Duke Funds to Retain Clinical Scientists at Yale
Yale School of Medicine AwardDoris Duke Foundation / YCCIDetails05/01/2023honor YCCI Scholar
Yale School of Medicine AwardYale Center for Clinical InvestigationDetails07/01/2021United States
Clinical Care
Overview
Ehimen Aneni, MD, MPH, is a specialist in cardiovascular medicine with a primary clinical focus on managing metabolic syndrome, a combination of conditions that increase the risk of heart disease, stroke, and diabetes. Dr. Aneni also treats heart rhythm disorders, including ventricular tachycardia, atrial flutter, and familial arrhythmias.
Dr. Aneni's research interests include obstructive sleep apnea and cardiovascular health, posterior reversible encephalopathy syndrome, and acute ischemic stroke.
A Yale Center for Clinical Investigation (YCCI) Scholar and recipient of the Doris Duke Funds to Retain Clinical Scientists at Yale, Dr. Aneni is also an instructor of medicine at Yale University School of Medicine.
Clinical Specialties
Fact Sheets
Sleep Apnea
Learn More on Yale MedicineFluoroscopy Imaging After Bariatric Surgery
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Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2022
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
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News
- February 19, 2024Source: Yale Medicine
9 Things You May Not Know About Cholesterol
- February 08, 2024Source: Yale Medicine
Blood Pressure: Your Questions Answered
- November 16, 2022
Discoveries & Impact (November 2022)
- August 12, 2022
Yale Cardiovascular Medicine faculty receive career development awards
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