Costin Ionescu, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Overview
Platelets play a central role in atherosclerosis and treatment relies in anti-platelet therapies. However, there are different clinical phenotypes of atherosclerosis. Combining basic and clinical research approach to various clinical phenotypes, we are investigating the roles of platelets in coronary and peripheral vascular disease.
Publications
2024
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
Regan C, Scierka L, Dardik A, Tonnessen B, Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 33: 466-471. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectives
2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategies
2019
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAge FactorsAgedAged, 80 and overAgingAnimalsAntioxidantsApoptosisBiomarkersBlood PlateletsCardiovascular DiseasesComorbidityDisease Models, AnimalFemaleHomeostasisHumansMaleMiceMiddle AgedOxidation-ReductionOxidative StressPlatelet ActivationPlatelet AdhesivenessReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsRisk patientsMouse studiesPlatelet phenotypeMajor adverse cardiovascular eventsHigh cardiovascular risk patientsAdaptive increaseAdverse cardiovascular eventsCentral pathophysiological roleCVD risk patientsCardiovascular risk patientsAggressive antiplatelet therapyEffect of comorbidityAge group 40Young healthy subjectsAntiplatelet therapyCardiovascular eventsYear age cohortAdvanced ageCVD patientsGroup 40Healthy subjectsPathophysiological roleElderly populationCardiovascular pathologyPatientsAntiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role
2015
Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients
Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi G, Mihos CG, Morel O, Nef HM, Gil I, Passaseo I, Pineda AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW, Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients. The American Journal Of Medicine 2015, 128: 654.e11-654.e19. PMID: 25660245, DOI: 10.1016/j.amjmed.2015.01.016.Peer-Reviewed Original ResearchConceptsTakotsubo syndromeCollaborative systematic reviewSystematic reviewRisk factorsInternational collaborative systematic reviewCardiovascular risk factorsChronic kidney diseaseComorbidities of patientsClinical characteristicsCommon comorbiditiesPulmonary diseaseKidney diseaseCumulative prevalenceThyroid diseaseComorbidity frequencyNeurologic diseaseRelevant prevalenceIndependent reviewersNineteen studiesComorbiditiesPatientsSyndromeEmotional stressorsDiseaseRelevant studies
2014
Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).
Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.Peer-Reviewed Original ResearchConceptsHigh-sensitivity C-reactive proteinC-reactive proteinAcute myocardial infarctionEmergency departmentCause rehospitalizationChest painMyocardial infarctionChest pain evaluationCoronary revascularizationHs-CRPConsecutive patientsFinal cohortPain evaluationMyocardial ischemiaClinical valuePatientsRehospitalizationPainInfarctionDepartmentDaysRevascularizationIschemiaCohortCRP
2011
Left ventricular noncompaction and aneurysm revealed by left ventriculography
Ionescu CN, Turcot D. Left ventricular noncompaction and aneurysm revealed by left ventriculography. Catheterization And Cardiovascular Interventions 2011, 80: 109-111. PMID: 21954168, DOI: 10.1002/ccd.23322.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsCardiac CatheterizationDefibrillators, ImplantableEchocardiographyElectric CountershockElectrocardiography, AmbulatoryHeart AneurysmHeart VentriclesHumansIsolated Noncompaction of the Ventricular MyocardiumMaleMiddle AgedPredictive Value of TestsRadiographyStroke VolumeTachycardia, VentricularVentricular Function, LeftWarfarinConceptsLeft ventriculographyCardiac catheterizationNoninvasive testsVentricular noncompactionNonobstructive coronary artery diseaseCoronary artery diseaseLeft ventricular aneurysmLeft ventricular noncompactionArtery diseaseEjection fractionVentricular aneurysmRare caseCatheterizationNoncompactionVentriculographyAneurysmsPatientsDisease
2010
Unexpected massive myocardial calcification
Ionescu C, Marcu C. Unexpected massive myocardial calcification. Netherlands Heart Journal 2010, 1-5. DOI: 10.1007/s12471-010-0009-9.Peer-Reviewed Original ResearchTreatment and outcomes of nonagenarians with ST-elevation myocardial infarction.
Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionPercutaneous coronary interventionReperfusion therapyMyocardial infarctionOutcome of nonagenariansMedical therapy groupAcute coronary syndromeMajority of patientsKaplan-Meier analysisProcedure-associated complicationsTreatment of patientsYears of ageHospital mortalityPCI groupCoronary syndromeCoronary interventionHospital dischargeOlder patientsSurvival benefitBetter prognosisCurrent guidelinesTherapy groupLower incidenceRetrospective analysisPatients
Academic Achievements & Community Involvement
Clinical Care
Overview
Costin Ionescu, MD, PhD, is an interventional cardiologist who diagnoses and treats a wide range of heart and vascular conditions, including coronary artery disease. He focuses on helping people prevent complications and manage existing cardiovascular disease, drawing on his interest in platelet biology and atherosclerosis.
As an assistant professor of medicine (cardiovascular medicine) at Yale School of Medicine, Dr. Ionescu studies the role of platelets in the development of coronary and peripheral vascular disease. By combining basic science and clinical research, he aims to refine anti-platelet therapies for individual patients.
Dr. Ionescu earned his medical degree from Carol Davila University of Medicine and received a doctoral degree from Wesleyan University. He completed his residency in internal medicine at the Hospital of St. Raphael, followed by a fellowship in cardiovascular disease at the same institution and an interventional cardiology fellowship at Tufts University School of Medicine.
Clinical Specialties
Cardiovascular Medicine; Interventional Cardiology
Fact Sheets
Angina
Learn More on Yale MedicinePercutaneous Coronary Intervention (PCI)
Learn More on Yale MedicineHeart Attack (Myocardial Infarction)
Learn More on Yale MedicineChest Pain
Learn More on Yale Medicine
Yale Medicine News
News
Get In Touch
Contacts
Appointment Number
Clinic Fax Number
Mailing Address
Cardiovascular Medicine
175 Sherman Ave, 6th floor
New Haven, CT 06511
United States
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.