Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?
Kallen AN, Ma J, Huang Y. Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Frontiers In Genetics 2012, 3: 240. PMID: 23162570, PMCID: PMC3499807, DOI: 10.3389/fgene.2012.00240.Peer-Reviewed Original ResearchRNA helicase ARibonucleoprotein complexesDEAD-box protein familyMiRNA-mediated repressionATP-dependent unwindingTranslation of genesStimulation of translationFamily of miRNAsSubset of miRNAsRNA helicasesProtein familyTarget mRNAsSame mRNAGene expressionPleiotropic rolesLin28Mode of actionRNA duplexesCell growthNeuronal cellsMiRNAsMRNAComplementary sequencesBrain synaptic functionSynaptic function