2016
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy
Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 2016, 30: 1881-1894. PMID: 27585592, PMCID: PMC5024685, DOI: 10.1101/gad.282194.116.Peer-Reviewed Original ResearchConceptsSUMO protease Ulp2Small ubiquitin-related modifierPost-translational protein modificationWhole-genome RNA sequencingNumerous cellular pathwaysG1 phase cyclinsGenome maintenanceChromosome IUlp2Particular chromosomeAdapts cellsCell divisionSUMO proteaseCellular stressRNA sequencingProtein modificationCellular pathwaysNormal copy numberTranscript levelsMost human tumorsCopy numberRapid adaptationExtra copiesChromosomesSpecific aneuploidies
2013
Sex-linked transcriptional divergence in the hermaphrodite fungus Neurospora tetrasperma
Samils N, Gioti A, Karlsson M, Sun Y, Kasuga T, Bastiaans E, Wang Z, Li N, Townsend JP, Johannesson H. Sex-linked transcriptional divergence in the hermaphrodite fungus Neurospora tetrasperma. Proceedings Of The Royal Society B 2013, 280: 20130862. PMID: 23782882, PMCID: PMC3712418, DOI: 10.1098/rspb.2013.0862.Peer-Reviewed Original ResearchConceptsMating typesFilamentous ascomycete Neurospora tetraspermaNeurospora tetraspermaMating-type locusGene expression levelsExpression divergenceTranscriptional divergencePhenotypic divergenceFungal AnaloguesRecombinational suppressionMat ASequence divergenceN. tetraspermaMale developmentDivergent regionsFemale developmentMolecular phenotypesGenesSexual dimorphismMale tissuesExpression levelsDivergencePhenotypeAgar mediumGenome
2011
Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae
Tang W, Dominska M, Greenwell PW, Harvanek Z, Lobachev KS, Kim HM, Narayanan V, Mirkin SM, Petes TD. Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae. PLOS Genetics 2011, 7: e1001270. PMID: 21249181, PMCID: PMC3020933, DOI: 10.1371/journal.pgen.1001270.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, FungalDNA Breaks, Double-StrandedDNA ReplicationGene ConversionMitosisSaccharomyces cerevisiaeTrinucleotide RepeatsConceptsDouble-strand breaksMitotic crossoversNon-reciprocal transferExpansions of trinucleotideFriedreich's ataxiaGenome instabilityMeiotic recombinationUnreplicated chromosomesDNA sequencesRecombination eventsCell cycleSaccharomyces cerevisaeYeastMajor classesChromosomesPotent sourceRepeatsHeterozygosityTrinucleotideCerevisaeRecombinationSequence
2000
Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast
Zhou J, Monson E, Teng S, Schulz V, Zakian V. Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 2000, 289: 771-774. PMID: 10926538, DOI: 10.1126/science.289.5480.771.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid MotifsAnimalsCatalysisCell LineChromosomes, FungalDNA DamageDNA HelicasesDNA ReplicationDNA, FungalGene ExpressionHumansMutagenesis, Site-DirectedPoint MutationRecombinant ProteinsRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidTelomeraseTelomere
1993
A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus
Lichter J, Wu J, Brooks-Wilson A, Difillipantonio M, Brewster S, Ward D, Goodfellow P, Kidd K. A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus. Human Genetics 1993, 90: 516-520. PMID: 8094065, DOI: 10.1007/bf00217451.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChromosome MappingChromosomes, FungalChromosomes, Human, Pair 10Cloning, MolecularCricetinaeDeoxyribonuclease EcoRIDNADNA ProbesFemaleGene FrequencyGene LibraryGenetic LinkageGenetic MarkersGenome, HumanHumansHybrid CellsIn Situ Hybridization, FluorescenceLod ScoreMaleMolecular Sequence DataMultiple Endocrine NeoplasiaPedigreePolymorphism, GeneticPolymorphism, Restriction Fragment LengthSequence Analysis, DNA
1992
Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein.
West A, Clark D, Martin J, Neupert W, Hartl F, Horwich A. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. Journal Of Biological Chemistry 1992, 267: 24625-24633. PMID: 1447206, DOI: 10.1016/s0021-9258(18)35810-1.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceChromosomes, FungalDNA, FungalGenes, FungalGenes, LethalGenes, SuppressorGenotypeMitochondriaMolecular Sequence DataMutationOpen Reading FramesPeptidesPlasmidsProtein ConformationRestriction MappingSaccharomyces cerevisiaeSequence DeletionSequence Homology, Amino AcidSuppression, GeneticTemperatureConceptsProtein importHydrophobic proteinsNH2-terminal signal peptideYeast genomic libraryNonfermentable carbon sourcesProteins of mitochondriaMitochondrial membrane proteinPrecursor proteinHigh-copy plasmidMitochondrial processingProtein translocationGenomic libraryPEP geneGrowth defectChromosomal genesMembrane proteinsMitochondrial matrixSignal peptideGenetic suppressionLethal mutationsMitochondrial membraneDouble disruptionRelated genesSequence analysisProteolytic removal
1991
Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation
Strobel S, Dervan P. Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation. Nature 1991, 350: 172-174. PMID: 1848684, DOI: 10.1038/350172a0.Peer-Reviewed Original ResearchConceptsTriple helix formationGenomic DNABase pairsYeast genomic DNAHelix formationSequence-specific DNALarge genomic DNAGenomic libraryMegabase pairsPhysical mappingEnzymatic cleavageRecognition motifSpecificity of bindingChromosomal DNARestriction endonuclease digestionManageable fragmentsRecognition sequenceGenetic markersDNA showRestriction enzymesQuantitative cleavageLarge DNADNAEndonuclease digestionChromosomes
1990
Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation
Strobel S, Dervan P. Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation. Science 1990, 249: 73-75. PMID: 2195655, DOI: 10.1126/science.2195655.Peer-Reviewed Original ResearchYeast suppressor mutations and transfer RNA processing
Nichols M, Willis I, Söll D. Yeast suppressor mutations and transfer RNA processing. Methods In Enzymology 1990, 181: 377-394. PMID: 2199758, DOI: 10.1016/0076-6879(90)81137-j.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernChromosomes, FungalGenes, FungalIndicators and ReagentsMolecular Sequence DataMutationNucleic Acid ConformationNucleic Acid HybridizationRNA Polymerase IIIRNA Processing, Post-TranscriptionalRNA, TransferRNA, Transfer, SerSaccharomyces cerevisiaeSuppression, GeneticTranscription FactorsTranscription, GeneticConceptsTRNA genesMature-sized tRNAsRNA processing reactionsPrimer-directed mutagenesisAminoacyl-tRNA synthetaseTransfer RNA moleculesCognate aminoacyl-tRNA synthetaseRNA processingSuppressor mutationsTRNA locusElongation factorProtein biosynthesisRibosomal interactionsRNA moleculesMutant strainStructural proteinsPink coloniesTranscription efficiencyProcessing reactionsProtein synthesisSuppressor functionTRNALow template concentrationsGenesLoci
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