2023
Oncogene-like addiction to aneuploidy in human cancers
Girish V, Lakhani A, Thompson S, Scaduto C, Brown L, Hagenson R, Sausville E, Mendelson B, Kandikuppa P, Lukow D, Yuan M, Stevens E, Lee S, Schukken K, Akalu S, Vasudevan A, Zou C, Salovska B, Li W, Smith J, Taylor A, Martienssen R, Liu Y, Sun R, Sheltzer J. Oncogene-like addiction to aneuploidy in human cancers. Science 2023, 381: eadg4521. PMID: 37410869, PMCID: PMC10753973, DOI: 10.1126/science.adg4521.Peer-Reviewed Original Research
2016
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy
Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 2016, 30: 1881-1894. PMID: 27585592, PMCID: PMC5024685, DOI: 10.1101/gad.282194.116.Peer-Reviewed Original ResearchConceptsSUMO protease Ulp2Small ubiquitin-related modifierPost-translational protein modificationWhole-genome RNA sequencingNumerous cellular pathwaysG1 phase cyclinsGenome maintenanceChromosome IUlp2Particular chromosomeAdapts cellsCell divisionSUMO proteaseCellular stressRNA sequencingProtein modificationCellular pathwaysNormal copy numberTranscript levelsMost human tumorsCopy numberRapid adaptationExtra copiesChromosomesSpecific aneuploidies
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply