IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax
Lopez-Perez M, Larsen M, Bayarri-Olmos R, Ampomah P, Stevenson L, Arévalo-Herrera M, Herrera S, Hviid L. IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax. Infection And Immunity 2018, 86: 10.1128/iai.00136-18. PMID: 29784859, PMCID: PMC6056870, DOI: 10.1128/iai.00136-18.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAntibodies, ProtozoanAntigens, ProtozoanChildChild, PreschoolColombiaFalse Positive ReactionsFemaleGlycosylationHumansImmunoassayImmunoglobulin GMalaria, FalciparumMalaria, VivaxMaleMiceMiddle AgedPregnancyPregnancy Complications, InfectiousRecombinant ProteinsYoung AdultConceptsIgG reactivityPregnant womenPfEMP1 proteinsInfected erythrocytesAcquisition of IgGPrevious malaria exposureDuffy-binding proteinErythrocyte membrane protein 1 (PfEMP1) familyPlacental parasitesClinical immunityMalaria immunityIgG responsesMalaria exposureRecombinant VAR2CSAMouse monoclonalVariant antigensColombian menIgGPlasma samplesRabbit antibodiesChinese hamster ovary cellsPregnancyVAR2CSAHamster ovary cellsMalaria
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