2021
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization
Bayarri-Olmos R, Rosbjerg A, Johnsen L, Helgstrand C, Bak-Thomsen T, Garred P, Skjoedt M. The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization. Journal Of Biological Chemistry 2021, 296: 100536. PMID: 33716040, PMCID: PMC7948531, DOI: 10.1016/j.jbc.2021.100536.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAngiotensin-Converting Enzyme 2AnimalsAntibodies, NeutralizingAntibodies, ViralConvalescenceCOVID-19DenmarkGene ExpressionHEK293 CellsHost-Pathogen InteractionsHumansImmune SeraImmunity, InnateMinkModels, MolecularMutationPandemicsProtein BindingProtein Structure, SecondaryRecombinant ProteinsSARS-CoV-2Spike Glycoprotein, CoronavirusVirus InternalizationConceptsReceptor-binding domainSevere acute respiratory syndrome coronavirus 2Angiotensin-converting enzyme 2 receptorAcute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Human angiotensin-converting enzyme 2 (ACE2) receptorPotential immune evasionSyndrome coronavirus 2Enzyme 2 (ACE2) receptorSpike gene mutationsBiolayer interferometry analysisVaccine strategiesCoronavirus 2Humoral immunityAntibody responseViral controlImmune responseMouse modelImmune evasionAntibody neutralizationReceptor adaptationOriginal WuhanSpike proteinGene mutationsGenetic variants
2005
Cortical γ-Aminobutyric Acid Type A–Benzodiazepine Receptors in Recovery From Alcohol Dependence: Relationship to Features of Alcohol Dependence and Cigarette Smoking
Staley JK, Gottschalk C, Petrakis IL, Gueorguieva R, O’Malley S, Baldwin R, Jatlow P, Verhoeff NP, Perry E, Weinzimmer D, Frohlich E, Ruff E, van Dyck CH, Seibyl JP, Innis RB, Krystal JH. Cortical γ-Aminobutyric Acid Type A–Benzodiazepine Receptors in Recovery From Alcohol Dependence: Relationship to Features of Alcohol Dependence and Cigarette Smoking. JAMA Psychiatry 2005, 62: 877-888. PMID: 16061765, DOI: 10.1001/archpsyc.62.8.877.Peer-Reviewed Original ResearchConceptsWeeks of abstinenceIomazenil single-photon emissionSingle photon emissionDays of sobrietyAlcohol dependenceIomazenil uptakeTomographic scanBenzodiazepine receptorsVoxel-based statistical parametric mappingReceptor adaptationDistribution volumeReceptor functionGamma-aminobutyric acid type ABenzodiazepine receptor levelsIodine I 123Reduced receptor functionHuman alcohol dependenceLast alcoholic drinkHealthy comparison groupStatistical parametric mappingAlcohol withdrawalClinical featuresSmoking statusCigarette smokingAcute withdrawal
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