2021
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nature Communications 2021, 12: 4569. PMID: 34315903, PMCID: PMC8316582, DOI: 10.1038/s41467-021-24824-z.Peer-Reviewed Original ResearchConceptsPutative causal genesGenome-wide association studiesUnderstanding of genesIntegrative genomic analysisTrans-ethnic studiesAssociation scanCausal genesGenomic analysisAssociation studiesDiverse ancestral backgroundsGenesSusceptibility genesBiobank JapanHost geneticsProtein levelsAncestral backgroundPathwayExpressionMRNA expressionSplicingRapid progressPhenomeGeneticsHost inflammatory responseCoagulation pathway
2014
Big Data In Health Care: Using Analytics To Identify And Manage High-Risk And High-Cost Patients
Bates D, Saria S, Ohno-Machado L, Shah A, Escobar G. Big Data In Health Care: Using Analytics To Identify And Manage High-Risk And High-Cost Patients. Health Affairs 2014, 33: 1123-1131. PMID: 25006137, DOI: 10.1377/hlthaff.2014.0041.Commentaries, Editorials and LettersConceptsBig dataClinical analyticsPrivacy concernsUse casesElectronic health recordsAnalyticsTypes of dataHealth recordsTypes of insightsNecessary analysisSupport of researchHigh-cost patientsUnprecedented opportunityMonitoring devicesCostHealth careAlgorithmMultiple organ systemsRapid progressInfrastructureUS health care systemHealth care systemSystemAdverse eventsClinical data
2011
Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling
Koche RP, Smith ZD, Adli M, Gu H, Ku M, Gnirke A, Bernstein BE, Meissner A. Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling. Cell Stem Cell 2011, 8: 96-105. PMID: 21211784, PMCID: PMC3220622, DOI: 10.1016/j.stem.2010.12.001.Peer-Reviewed Original ResearchConceptsPluripotent stem cell stateEuchromatic histone modificationsRepressive H3K27me3 modificationGenome-wide changesStem cell stateChromatin remodelingH3K4 methylationHistone modificationsH3K27me3 modificationEpigenetic responsesTranscriptional changesSomatic cellsRegulatory eventsGene promoterEpigenetic changesCell statesCorresponding lociSomatic identityMechanistic questionsFactor inductionEarly eventsLociH3K4me2ReprogrammingRapid progress
2010
Chapter 3 Uncovering the Genetic Architecture of Multiple Sclerosis
De Jager P, Hafler D. Chapter 3 Uncovering the Genetic Architecture of Multiple Sclerosis. Blue Books Of Neurology 2010, 35: 43-56. DOI: 10.1016/b978-1-4160-6068-0.00003-6.Peer-Reviewed Original ResearchGenetic architectureSusceptibility lociWhole-genome association scansCommon human diseasesMajor histocompatibility complexMultiple sclerosis geneticsCommon genetic variationAssociation scanHuman genomeGenetic variationSingle locusHuman diseasesLociFirst glimpseCurrent discoveriesHistocompatibility complexGenotyped subjectsGenetic susceptibilityGenomeRapid progressHuman leukocyte antigenGeneticsHapMapConvergence of resourcesMultiple sclerosis
1993
From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters
Rudnick G, Clark J. From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters. Biochimica Et Biophysica Acta 1993, 1144: 249-263. PMID: 8104483, DOI: 10.1016/0005-2728(93)90109-s.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPresynaptic plasma membraneBiogenic amine neurotransmittersEndogenous regulatory mechanismsSynaptic transmitter levelsPlasma membraneIndividual proteinsRegulatory mechanismsTransport systemMolecular levelSynaptic vesiclesAmine neurotransmittersIon gradientsTransportersVesiclesCDNARapid progressProteinNeurotransmittersRegulationMechanismMembraneSynapseTransmitter levelsJuxtacrine cell signaling molecules
Bosenberg M, Massagué J. Juxtacrine cell signaling molecules. Current Opinion In Cell Biology 1993, 5: 832-838. PMID: 7694603, DOI: 10.1016/0955-0674(93)90032-l.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCell MembraneDrosophila ProteinsEpidermal Growth FactorEye ProteinsGrowth SubstancesHematopoietic Cell Growth FactorsHumansMembrane GlycoproteinsNerve Growth FactorsReceptors, Cell SurfaceReceptors, PeptideSignal TransductionStem Cell FactorTumor Necrosis Factor-alphaConceptsCell adhesion moleculeMembrane-anchored growth factorsIntimate cell-cell contactCell-cell contactDiffusible growth factorsAdhesion moleculesGrowth factorTissue developmentIntercellular communicationJuxtacrine interactionsJuxtacrine stimulationClass of moleculesAdjacent cellsCellsRapid progressMoleculesReceptorsBiologistsMaintenanceIdentification
1974
New aspects in tRNA biosynthesis
Schäfer K, Söll D. New aspects in tRNA biosynthesis. Biochimie 1974, 56: 795-804. PMID: 4614860, DOI: 10.1016/s0300-9084(74)80500-6.Peer-Reviewed Original Research
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