2016
A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans
Houri-Ze'evi L, Korem Y, Sheftel H, Faigenbloom L, Toker I, Dagan Y, Awad L, Degani L, Alon U, Rechavi O. A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell 2016, 165: 88-99. PMID: 27015309, DOI: 10.1016/j.cell.2016.02.057.Peer-Reviewed Original ResearchConceptsAncestral responsesSmall RNAsC. elegansRNAi responseEndogenous small RNAsSilencing of genesRNA sequencing analysisRNA inheritanceHeritable silencingRNAi factorsExposure to dsRNAManipulating genesEpigenetic responsesComplementary sequencesEpigenetic effectsGenesRNAiTransgenerational effectsSilencingRNAFeedback loopInheritance mechanismDsRNAElegansAncestor
2011
Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling
Koche RP, Smith ZD, Adli M, Gu H, Ku M, Gnirke A, Bernstein BE, Meissner A. Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling. Cell Stem Cell 2011, 8: 96-105. PMID: 21211784, PMCID: PMC3220622, DOI: 10.1016/j.stem.2010.12.001.Peer-Reviewed Original ResearchConceptsPluripotent stem cell stateEuchromatic histone modificationsRepressive H3K27me3 modificationGenome-wide changesStem cell stateChromatin remodelingH3K4 methylationHistone modificationsH3K27me3 modificationEpigenetic responsesTranscriptional changesSomatic cellsRegulatory eventsGene promoterEpigenetic changesCell statesCorresponding lociSomatic identityMechanistic questionsFactor inductionEarly eventsLociH3K4me2ReprogrammingRapid progress
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